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Rabbit Polyclonal Phospho-CFL1-Y88/CFL2-Y88 antibody (AP0329)
Supplier: ABclonal Inc.
Recommended applications: WB,IHC
WB 1:500 – 1:1000
IHC 1:50 – 1:100
Recommended protocols: check protocols
Click or hover above images to see image description for Rabbit Polyclonal Phospho-CFL1-Y88/CFL2-Y88 antibody.
Check alternative names for the antibodyExpand
18 kDa phosphoprotein antibody|CFL antibody|Cofilin 1 (non-muscle) antibody|cofilin 1 antibody|Cofilin 2 (muscle) antibody|cofilin 2 antibody|Cofilin, muscle isoform antibody|Cofilin, non-muscle isoform antibody|NEM7 antibody|p18 antibody|Anti-Cofilin antibody (ab42824)
SCBT cat No: sc-53934|sc-32158|sc-32157|sc-166958|sc-32160|sc-376476|sc-33779|sc-8441|sc-136179|sc-164079|sc-130444|
Rabbit Polyclonal Phospho-CFL1-Y88/CFL2-Y88 antibody
|Catalogue No.|| |
A phospho specific peptide corresponding to residues surrounding Y88 of human CFL1/CFL2
|Recommended dilution|| |
WB 1:500 – 1:1000<br/>IHC 1:50 – 1:100
|Molecular weight|| |
Phospho-CFL1-Y88/CFL2-Y88 antibody was tube-contained.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Alternative antibody names|| |
|Database links|| |
Human UniProt/Swiss-Prot:<a href="http://www.uniprot.org/uniprot/P23528">P23528</a>
|Protein names|| |
|Protein function|| |
Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Regulates actin cytoskeleton dynamics. Important for normal progress through mitosis and normal cytokinesis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation (PubMed:11812157, PubMed:15580268, PubMed:21834987, PubMed:23633677). Required for neural tube morphogenesis and neural crest cell migration (By similarity).
|Protein tissue specificity|| |
Widely distributed in various tissues.
|Protein sequence and domain|| |
Belongs to the actin-binding proteins ADF family.; Contains 1 ADF-H domain.
|Protein post-translational modifications|| |
Inactivated by phosphorylation on Ser-3. Phosphorylated on Ser-3 in resting cells (By similarity). Dephosphorylated by PDXP/chronophin; this restores its activity in promoting actin filament depolymerization. The phosphorylation of Ser-24 may prevent recognition of the nuclear localization signal (By similarity). Phosphorylated via a ARRB1-RAC1-LIMK1-PAK1 cascade upon active ligand stimulation of atypical chemokine receptor ACKR2.
|Protein cellular localization|| |
Nucleus matrix . Cytoplasm, cytoskeleton . Cell projection, ruffle membrane ; Peripheral membrane protein ; Cytoplasmic side . Cell projection, lamellipodium membrane ; Peripheral membrane protein ; Cytoplasmic side . Note=Colocalizes with the actin cytoskeleton in membrane ruffles and lamellipodia. Detected at the cleavage furrow and contractile ring during cytokinesis. Almost completely in nucleus in cells exposed to heat shock or 10% dimethyl sulfoxide.
Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods.
|Research area|| |
<a href="http://antibodyplus.com/research-areas/">All research areas</a>><a href="http://antibodyplus.com/Structural-Proteins/">Structural Proteins</a>><a href="http://antibodyplus.com/product-tag/Cofilin/">Cofilin</a><br><a href="http://antibodyplus.com/product-tag/Structural-Proteins/"> (View all antibody categories related to Structural Proteins)</a>
AntibodyPlus can customize Phospho-CFL1-Y88/CFL2-Y88 antibody according to your requirement, including bulk product size,etc. Please contact firstname.lastname@example.org. AntibodyPlus provides antibody trial sample for your own antibody validation.
|Product type|| |
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