Rabbit Polyclonal Phospho-CHOP (S30) antibody (STJ91075)


Reactivity: Human, Mouse
Applications: WB, IHC, IF, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Rabbit Polyclonal Phospho-CHOP (S30) antibody (STJ91075)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, IHC, IF, ELISA

Recommended dilution: WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:20000;

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for CHOP (phospho Ser30) Polyclonal Antibody.

Alternative names:

Check alternative names for the antibody


DDIT3 antibody, CHOP antibody, CHOP10 antibody, GADD153 antibody,|C/EBP homologous protein antibody|C/EBP Homology Protein antibody|C/EBP zeta antibody|C/EBP-homologous protein 10 antibody|C/EBP-homologous protein antibody|CCAAT/enhancer binding protein homologous protein antibody|CEBPZ antibody|CHOP 10 antibody|CHOP antibody|CHOP-10 antibody|CHOP10 antibody|DDIT 3 antibody|DDIT-3 antibody|Ddit3 antibody|DDIT3_HUMAN antibody|DNA Damage Inducible Transcript 3 antibody|DNA damage-inducible transcript 3 protein antibody|GADD 153 antibody|GADD153 antibody|Growth Arrest and DNA Damage Inducible Protein 153 antibody|Growth arrest and DNA damage inducible protein GADD153 antibody|Growth arrest and DNA damage-inducible protein GADD153 antibody|MGC4154 antibody|Anti-DDIT3 antibody [9C8] (ab11419)
SCBT cat No: sc-71136|sc-56107|sc-7351|sc-575|sc-166682|sc-793|



CHOP (phospho Ser30) Polyclonal Antibody

Catalogue No.



Human, Mouse


Phospho-CHOP (S30) Polyclonal Antibody detects endogenous levels of CHOP protein only when phosphorylated at S30.


Synthesized phospho-peptide derived from CHOP (phospho Ser30) at AA range 10-90





Recommended dilution

WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:20000;







Molecular weight

19 kDa


CHOP (phospho Ser30) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.


1 mg/ml


CHOP (phospho Ser30) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.


-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

DNA damage-inducible transcript 3 protein antibody, DDIT-3 antibody, C/EBP zeta antibody, C/EBP-homologous protein antibody, CHOP antibody, C/EBP-homologous protein 10 antibody, CHOP-10 antibody, CCAAT/enhancer-binding protein homologous protein antibody, Growth arrest and DNA damage-inducible protein GADD153 antibody

Database links

Human UniProt/Swiss-Prot:P35638;Mouse UniPort/Swiss-Prot: P35639;Rat UniProt/Swiss-Port: Q496Y7;Human Entrez Gene: 1649;Mouse Entrez Gene: 13198;Rat Entrez Gene: Rn.11183

Protein names

DNA damage-inducible transcript 3 protein , DDIT-3 , C/EBP zeta , C/EBP-homologous protein , CHOP , C/EBP-homologous protein 10 , CHOP-10 , CCAAT/enhancer-binding protein homologous protein , Growth arrest and DNA damage-inducible protein GADD153

Protein function

Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer-binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression of C/EBP regulated genes. Positively regulates the transcription of TRIB3, IL6, IL8, IL23, TNFRSF10B/DR5, PPP1R15A/GADD34, BBC3/PUMA, BCL2L11/BIM and ERO1L. Negatively regulates; expression of BCL2 and MYOD1, ATF4-dependent transcriptional activation of asparagine synthetase (ASNS), CEBPA-dependent transcriptional activation of hepcidin (HAMP) and CEBPB-mediated expression of peroxisome proliferator-activated receptor gamma (PPARG). Inhibits the canonical Wnt signaling pathway by binding to TCF7L2/TCF4, impairing its DNA-binding properties and repressing its transcriptional activity. Plays a regulatory role in the inflammatory response through the induction of caspase-11 (CASP4/CASP11) which induces the activation of caspase-1 (CASP1) and both these caspases increase the activation of pro-IL1B to mature IL1B which is involved in the inflammatory response.

Protein tissue specificity

By oxidative stress, amino-acid deprivation, hypoxia and ER stress. During ER stress, induced by a EIF2AK3/ATF4 pathway and/or ERN1/ATF6 pathway. Expression is suppressed by TLR-TRIF signaling pathway during prolonged ER stress.

Involvement in disease

Myxoid liposarcoma (MXLIPO) [MIM:613488]: A soft tissue tumor that tends to occur in the limbs (especially the thigh) of patients ranging in age from 35 to 55 years. It is defined by the presence of a hypocellular spindle cell proliferation set in a myxoid background, often with mucin pooling. Lipoblasts tend to be small and often monovacuolated and to cluster around vessels or at the periphery of the lesion. . Note: The gene represented in this entry may be involved in disease pathogenesis. A chromosomal aberration involving DDIT3 has been found in a patient with malignant myxoid liposarcoma. Translocation t(12;16)(q13;p11) with FUS (PubMed:7503811). .

Protein sequence and domain

The N-terminal region is necessary for its proteasomal degradation, transcriptional activity and interaction with EP300/P300. / Belongs to the bZIP family. / Contains 1 bZIP (basic-leucine zipper) domain.

Protein post-translational modifications

Ubiquitinated, leading to its degradation by the proteasome. / Phosphorylation at serine residues by MAPK14 enhances its transcriptional activation activity while phosphorylation at serine residues by CK2 inhibits its transcriptional activation activity.

Protein cellular localization

Cytoplasm / Nucleus

Research area

All research areas>Transcription Regulators>AFF4
(View all antibody categories related to Transcription Regulators)


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St John’s Laboratory Ltd.

Product type

Primary antibody


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