Rabbit Polyclonal Phospho-CKR-5 (S349) antibody (STJ90450)

$99.00$319.00

Reactivity: Human
Applications: WB, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Rabbit Polyclonal Phospho-CKR-5 (S349) antibody (STJ90450)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, ELISA

Recommended dilution: WB 1:500-1:2000; ELISA 1:5000;

Recommended protocols: check protocols

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Alternative names:

Check alternative names for the antibody

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CCR5 antibody, CMKBR5 antibody,|AM4 7 antibody|C C chemokine receptor type 5 antibody|C C CKR 5 antibody|C-C chemokine receptor type 5 antibody|C-C CKR-5 antibody|C-C motif chemokine receptor 5 A159A antibody|CC Chemokine Receptor 5 antibody|CC Chemokine Receptor Type 5 antibody|CC CKR 5 antibody|CC-CKR-5 antibody|CCCKR 5 antibody|CCCKR5 antibody|CCR 5 antibody|CCR-5 antibody|CCR5 antibody|CCR5 chemokine (C C motif) receptor 5 antibody|CCR5_HUMAN antibody|CD 195 antibody|CD195 antibody|CD195 Antigen antibody|Chemokine C C motif receptor 5 antibody|Chemokine receptor CCR5 antibody|CHEMR13 antibody|CKR 5 antibody|CKR5 antibody|CMKBR 5 antibody|CMKBR5 antibody|FLJ78003 antibody|HIV 1 Fusion Coreceptor antibody|HIV-1 fusion coreceptor antibody|HIV1 fusion coreceptor antibody|IDDM22 antibody|MIP-1 alpha receptor antibody|Anti-CCR5 antibody (ab65850)
SCBT cat No: sc-6128|sc-8359|sc-17833|sc-55484|sc-13950|sc-6129|sc-8283|sc-32304|sc-57072|sc-53792|

 

Name

CKR-5 (phospho Ser349) Polyclonal Antibody

Catalogue No.

STJ90450

Reactivity

Human

Specificity

Phospho-CKR-5 (S349) Polyclonal Antibody detects endogenous levels of CKR-5 protein only when phosphorylated at S349.

Immunogen

Synthesized phospho-peptide derived from CKR-5 (phospho Ser349) at AA range 280-360

Host

Rabbit

Applications

WB, ELISA

Recommended dilution

WB 1:500-1:2000; ELISA 1:5000;

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

40 kDa

Formulation

CKR-5 (phospho Ser349) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

CKR-5 (phospho Ser349) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

C-C chemokine receptor type 5 antibody, C-C CKR-5 antibody, CC-CKR-5 antibody, CCR-5 antibody, CCR5 antibody, CHEMR13 antibody, HIV-1 fusion coreceptor antibody, CD antigen CD195 antibody

Database links

Human UniProt/Swiss-Prot:P51681;Mouse UniPort/Swiss-Prot: P51682;Rat UniProt/Swiss-Port: O08556;Human Entrez Gene: 1234;Mouse Entrez Gene: 12774;Rat Entrez Gene: Rn.10736

Protein names

C-C chemokine receptor type 5 , C-C CKR-5 , CC-CKR-5 , CCR-5 , CCR5 , CHEMR13 , HIV-1 fusion coreceptor , CD antigen CD195

Protein function

Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 R5 isolates. / (Microbial infection) Acts as a receptor for human immunodeficiency virus-1/HIV-1.

Protein tissue specificity

Highly expressed in spleen, thymus, in the myeloid cell line THP-1, in the promyeloblastic cell line KG-1a and on CD4+ and CD8+ T-cells. Medium levels in peripheral blood leukocytes and in small intestine. Low levels in ovary and lung.

Involvement in disease

Diabetes mellitus, insulin-dependent, 22 (IDDM22) [MIM:612522]: A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical features are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. . Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.

Protein sequence and domain

Belongs to the G-protein coupled receptor 1 family.

Protein post-translational modifications

Sulfated on at least 2 of the N-terminal tyrosines. Sulfation contributes to the efficiency of HIV-1 entry and is required for efficient binding of the chemokines, CCL3 and CCL4. / O-glycosylated, but not N-glycosylated. Ser-6 appears to be the major site. Also sialylated glycans present which contribute to chemokine binding. Thr-16 and Ser-17 may also be glycosylated and, if so, with small moieties such as a T-antigen. / Palmitoylation in the C-terminal is important for cell surface expression, and to a lesser extent, for HIV entry. / Phosphorylation on serine residues in the C-terminal is stimulated by binding CC chemokines especially by APO-RANTES.

Protein cellular localization

Cell membrane / Multi-pass membrane protein

Research area

All research areas>Membrane Receptors>C-C Chemokine Receptor
(View all antibody categories related to Membrane Receptors)

Note

AntibodyPlus can customize CKR-5 (phospho Ser349) Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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