Rabbit Polyclonal Phospho-COP1 (S387) antibody (STJ90637)

$99.00$319.00

Reactivity: Human, Mouse
Applications: WB, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Rabbit Polyclonal Phospho-COP1 (S387) antibody (STJ90637)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, ELISA

Recommended dilution: WB 1:500-1:2000; ELISA 1:5000;

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for COP1 (phospho Ser387) Polyclonal Antibody.

Alternative names:

Check alternative names for the antibody

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RFWD2 antibody, COP1 antibody, RNF200 antibody,|Constitutive photomorphogenesis protein 1 homolog antibody|COP antibody|E3 ubiquitin-protein ligase RFWD2 antibody|hCOP1 antibody|Rfwd2 antibody|RFWD2_HUMAN antibody|ring finger and WD repeat domain 2 antibody|RING finger and WD repeat domain protein 2 antibody|RING finger protein 200 antibody|Anti-COP1 antibody (ab56400)
SCBT cat No: sc-166799|sc-34592|

 

Name

COP1 (phospho Ser387) Polyclonal Antibody

Catalogue No.

STJ90637

Reactivity

Human, Mouse

Specificity

Phospho-COP1 (S387) Polyclonal Antibody detects endogenous levels of COP1 protein only when phosphorylated at S387.

Immunogen

Synthesized phospho-peptide derived from COP1 (phospho Ser387) at AA range 330-410

Host

Rabbit

Applications

WB, ELISA

Recommended dilution

WB 1:500-1:2000; ELISA 1:5000;

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

100 kDa

Formulation

COP1 (phospho Ser387) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

COP1 (phospho Ser387) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

E3 ubiquitin-protein ligase RFWD2 antibody, Constitutive photomorphogenesis protein 1 homolog antibody, hCOP1 antibody, RING finger and WD repeat domain protein 2 antibody, RING finger protein 200 antibody

Database links

Human UniProt/Swiss-Prot:Q8NHY2;Mouse UniPort/Swiss-Prot: Q9R1A8;Rat UniProt/Swiss-Port: Q5BJY0;Human Entrez Gene: 64326;Mouse Entrez Gene: 26374;Rat Entrez Gene: Rn.8617

Protein names

E3 ubiquitin-protein ligase RFWD2 , Constitutive photomorphogenesis protein 1 homolog , hCOP1 , RING finger and WD repeat domain protein 2 , RING finger protein 200

Protein function

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Involved in JUN ubiquitination and degradation. Directly involved in p53 (TP53) ubiquitination and degradation, thereby abolishing p53-dependent transcription and apoptosis. Ubiquitinates p53 independently of MDM2 or RCHY1. Probably mediates E3 ubiquitin ligase activity by functioning as the essential RING domain subunit of larger E3 complexes. In contrast, it does not constitute the catalytic RING subunit in the DCX DET1-COP1 complex that negatively regulates JUN, the ubiquitin ligase activity being mediated by RBX1. Involved in 14-3-3 protein sigma/SFN ubiquitination and proteasomal degradation, leading to AKT activation and promotion of cell survival. Ubiquitinates MTA1 leading to its proteasomal degradation. /

Protein tissue specificity

Ubiquitously expressed at low level. Expressed at higher level in testis, placenta, skeletal muscle and heart.

Protein sequence and domain

The RING finger domain, in addition to its role in ubiquitination, functions as a structural scaffold to bring two clusters of positive-charged residues within spatial proximity to mimic a bipartite nuclear localization signal (NLS). / Belongs to the COP1 family. / Contains 1 RING-type zinc finger. / Contains 7 WD repeats.

Protein post-translational modifications

Autoubiquitinated. MTA1 destabilizes it by promoting its autoubiquitination.

Protein cellular localization

Nucleus speckle / Cytoplasm

Research area

All research areas>Tumor Suppressor/Apoptosis>COP1
(View all antibody categories related to Tumor Suppressor/Apoptosis)

Note

AntibodyPlus can customize COP1 (phospho Ser387) Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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