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Rabbit Polyclonal Phospho-COP1 (S387) antibody (STJ90637)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-1:2000; ELISA 1:5000;
Recommended protocols: check protocols
Click or hover above images to see image description for COP1 (phospho Ser387) Polyclonal Antibody.
Check alternative names for the antibodyExpand
RFWD2 antibody, COP1 antibody, RNF200 antibody,|Constitutive photomorphogenesis protein 1 homolog antibody|COP antibody|E3 ubiquitin-protein ligase RFWD2 antibody|hCOP1 antibody|Rfwd2 antibody|RFWD2_HUMAN antibody|ring finger and WD repeat domain 2 antibody|RING finger and WD repeat domain protein 2 antibody|RING finger protein 200 antibody|Anti-COP1 antibody (ab56400)
SCBT cat No: sc-166799|sc-34592|
COP1 (phospho Ser387) Polyclonal Antibody
|Catalogue No.|| |
Phospho-COP1 (S387) Polyclonal Antibody detects endogenous levels of COP1 protein only when phosphorylated at S387.
Synthesized phospho-peptide derived from COP1 (phospho Ser387) at AA range 330-410
|Recommended dilution|| |
WB 1:500-1:2000; ELISA 1:5000;
|Molecular weight|| |
COP1 (phospho Ser387) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
COP1 (phospho Ser387) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
E3 ubiquitin-protein ligase RFWD2 antibody, Constitutive photomorphogenesis protein 1 homolog antibody, hCOP1 antibody, RING finger and WD repeat domain protein 2 antibody, RING finger protein 200 antibody
|Protein names|| |
E3 ubiquitin-protein ligase RFWD2 , Constitutive photomorphogenesis protein 1 homolog , hCOP1 , RING finger and WD repeat domain protein 2 , RING finger protein 200
|Protein function|| |
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Involved in JUN ubiquitination and degradation. Directly involved in p53 (TP53) ubiquitination and degradation, thereby abolishing p53-dependent transcription and apoptosis. Ubiquitinates p53 independently of MDM2 or RCHY1. Probably mediates E3 ubiquitin ligase activity by functioning as the essential RING domain subunit of larger E3 complexes. In contrast, it does not constitute the catalytic RING subunit in the DCX DET1-COP1 complex that negatively regulates JUN, the ubiquitin ligase activity being mediated by RBX1. Involved in 14-3-3 protein sigma/SFN ubiquitination and proteasomal degradation, leading to AKT activation and promotion of cell survival. Ubiquitinates MTA1 leading to its proteasomal degradation. /
|Protein tissue specificity|| |
Ubiquitously expressed at low level. Expressed at higher level in testis, placenta, skeletal muscle and heart.
|Protein sequence and domain|| |
The RING finger domain, in addition to its role in ubiquitination, functions as a structural scaffold to bring two clusters of positive-charged residues within spatial proximity to mimic a bipartite nuclear localization signal (NLS). / Belongs to the COP1 family. / Contains 1 RING-type zinc finger. / Contains 7 WD repeats.
|Protein post-translational modifications|| |
Autoubiquitinated. MTA1 destabilizes it by promoting its autoubiquitination.
|Protein cellular localization|| |
Nucleus speckle / Cytoplasm
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St John’s Laboratory Ltd.
|Product type|| |
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