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Rabbit Polyclonal Phospho-Cortactin (Y421) antibody (STJ90232)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IHC, ELISA
Recommended dilution: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:20000;
Recommended protocols: check protocols
Click or hover above images to see image description for Cortactin (phospho Tyr421) Polyclonal Antibody.
Check alternative names for the antibodyExpand
CTTN antibody, EMS1 antibody,|Amplaxin antibody|CTTN antibody|EMS 1 antibody|EMS1 antibody|FLJ34459 antibody|Mammary tumor and squamous cell carcinoma associated antibody|Oncogene EMS1 antibody|p80/85 src substrate antibody|Src substrate cortactin antibody|SRC8_HUMAN antibody|Anti-Cortactin antibody [EP1922Y] (ab81208)
SCBT cat No: sc-136134|sc-55578|sc-55588|sc-30770|sc-30771|sc-6544|sc-271173|sc-11408|sc-55579|sc-30772|sc-242504|
Cortactin (phospho Tyr421) Polyclonal Antibody
|Catalogue No.|| |
Human, Mouse, Rat
Phospho-Cortactin (Y421) Polyclonal Antibody detects endogenous levels of Cortactin protein only when phosphorylated at Y421.
Synthesized phospho-peptide derived from Cortactin (phospho Tyr421) at AA range 360-440
WB, IHC, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:20000;
|Molecular weight|| |
Cortactin (phospho Tyr421) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Cortactin (phospho Tyr421) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Src substrate cortactin antibody, Amplaxin antibody, Oncogene EMS1 antibody
|Protein names|| |
Src substrate cortactin , Amplaxin , Oncogene EMS1
|Protein function|| |
Contributes to the organization of the actin cytoskeleton and cell shape . Plays a role in the formation of lamellipodia and in cell migration. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density (By similarity). Plays a role in the invasiveness of cancer cells, and the formation of metastases . Plays a role in focal adhesion assembly and turnover (By similarity). In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement . Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cell membrane . Plays a role in receptor-mediated endocytosis via clathrin-coated pits (By similarity). Required for stabilization of KCNH1 channels at the cell membrane .
|Protein sequence and domain|| |
The SH3 motif may mediate binding to the cytoskeleton. / Contains 7 cortactin repeats. / Contains 1 SH3 domain.
|Protein post-translational modifications|| |
Phosphorylated by PKN2 at both serine and threonine residues in a GTP-bound Rac1-dependent manner in hyaluronan-induced astrocytes and hence down-regulated CTTN ability to associates with filamentous actin (By similarity). Phosphorylated on tyrosine residues in response to CHRM1 activation (By similarity). Phosphorylated by PTK2/FAK1 in response to cell adhesion (By similarity). Phosphorylated by FER. Tyrosine phosphorylation in transformed cells may contribute to cellular growth regulation and transformation. Phosphorylated in response to FGR activation. Phosphorylation by SRC promotes MYLK binding.
|Protein cellular localization|| |
Cytoplasm > cytoskeleton / Cell projection > lamellipodium / Cell projection > ruffle / Cell projection > dendrite / Cell projection / Cell membrane / Peripheral membrane protein / Cell projection > podosome / Cell junction / Cell junction > focal adhesion / Membrane > clathrin-coated pit / Cell projection > dendritic spine / Cytoplasm > cell cortex
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St John’s Laboratory Ltd.
|Product type|| |
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