Rabbit Polyclonal Phospho-cPLA2 (S505) antibody (STJ91028)

$99.00$319.00

Reactivity: Human, Mouse, Rat
Applications: WB, IHC, IF, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Rabbit Polyclonal Phospho-cPLA2 (S505) antibody (STJ91028)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, IHC, IF, ELISA

Recommended dilution: WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:10000;

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for cPLA2 (phospho Ser505) Polyclonal Antibody.

Alternative names:

Check alternative names for the antibody

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PLA2G4A antibody, CPLA2 antibody, PLA2G4 antibody,|Calcium dependent phospholipid binding protein antibody|CPLA 2 antibody|cPLA2 alpha antibody|cPLA2 antibody|Cytosolic phospholipase A2 antibody|Cytosolic phospholipase A2 group IVA antibody|Lysophospholipase antibody|MGC126350 antibody|PA24A_HUMAN antibody|Phosphatidylcholine 2 acylhydrolase antibody|Phosphatidylcholine 2-acylhydrolase antibody|Phospholipase A2 group 4 A antibody|Phospholipase A2 group IVA (cytosolic calcium dependent) antibody|Phospholipase A2 group IVA antibody|PhospholipaseA2 antibody|PLA2G4 antibody|pla2g4a antibody|Phospho anti-Phospholipase A2 (S505) antibody (ab53105)
SCBT cat No: sc-20511|

 

Name

cPLA2 (phospho Ser505) Polyclonal Antibody

Catalogue No.

STJ91028

Reactivity

Human, Mouse, Rat

Specificity

Phospho-cPLA2 (S505) Polyclonal Antibody detects endogenous levels of cPLA2 protein only when phosphorylated at S505.

Immunogen

Synthesized phospho-peptide derived from cPLA2 (phospho Ser505) at AA range 440-520

Host

Rabbit

Applications

WB, IHC, IF, ELISA

Recommended dilution

WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:10000;

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

110 kDa

Formulation

cPLA2 (phospho Ser505) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

cPLA2 (phospho Ser505) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Cytosolic phospholipase A2 antibody, cPLA2 antibody, Phospholipase A2 group IVA antibody

Database links

Human UniProt/Swiss-Prot:P47712;Mouse UniPort/Swiss-Prot: P47713;Rat UniProt/Swiss-Port: Q6IRF5;Human Entrez Gene: 5321;Mouse Entrez Gene: 18783;Rat Entrez Gene: Rn.10162

Protein names

Cytosolic phospholipase A2 , cPLA2 , Phospholipase A2 group IVA

Protein function

Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response. / Phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate. / 2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate. / Stimulated by agonists such as ATP, EGF, thrombin and bradykinin as well as by cytosolic Ca2+. / 2.7 µmol/min/mg enzyme for the phospholipase A2 reaction / 4.6 µmol/min/mg enzyme for the lysophosphatase reaction

Protein tissue specificity

Expressed in various tissues such as macrophages, platelets, neutrophils, fibroblasts and lung endothelium.

Involvement in disease

Note: PLA2G4A mutations resulting in phospholipase A2 deficiency have been found in a patient affected by recurrent episodes of multiple complicated ulcers of the small intestine, not due to cyclooxygenase inhibitors use. Disease features also include platelet dysfunction, and globally decreased eicosanoid synthesis (PubMed:18451993). .

Protein sequence and domain

The N-terminal C2 domain associates with lipid membranes upon calcium binding. It modulates enzyme activity by presenting the active site to its substrate in response to elevations of cytosolic Ca2+. / Contains 1 C2 domain. / Contains 1 PLA2c domain.

Protein post-translational modifications

Activated by phosphorylation at both Ser-505 and Ser-727.

Protein cellular localization

Cytoplasm / Cytoplasmic vesicle

Research area

All research areas>Synthesis and Degradation>cPLA
(View all antibody categories related to Synthesis and Degradation)

Note

AntibodyPlus can customize cPLA2 (phospho Ser505) Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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