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Rabbit Polyclonal Phospho-cPLA2 (S505) antibody (STJ91028)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IHC, IF, ELISA
Recommended dilution: WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:10000;
Recommended protocols: check protocols
Click or hover above images to see image description for cPLA2 (phospho Ser505) Polyclonal Antibody.
Check alternative names for the antibodyExpand
PLA2G4A antibody, CPLA2 antibody, PLA2G4 antibody,|Calcium dependent phospholipid binding protein antibody|CPLA 2 antibody|cPLA2 alpha antibody|cPLA2 antibody|Cytosolic phospholipase A2 antibody|Cytosolic phospholipase A2 group IVA antibody|Lysophospholipase antibody|MGC126350 antibody|PA24A_HUMAN antibody|Phosphatidylcholine 2 acylhydrolase antibody|Phosphatidylcholine 2-acylhydrolase antibody|Phospholipase A2 group 4 A antibody|Phospholipase A2 group IVA (cytosolic calcium dependent) antibody|Phospholipase A2 group IVA antibody|PhospholipaseA2 antibody|PLA2G4 antibody|pla2g4a antibody|Phospho anti-Phospholipase A2 (S505) antibody (ab53105)
SCBT cat No: sc-20511|
cPLA2 (phospho Ser505) Polyclonal Antibody
|Catalogue No.|| |
Human, Mouse, Rat
Phospho-cPLA2 (S505) Polyclonal Antibody detects endogenous levels of cPLA2 protein only when phosphorylated at S505.
Synthesized phospho-peptide derived from cPLA2 (phospho Ser505) at AA range 440-520
WB, IHC, IF, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:10000;
|Molecular weight|| |
cPLA2 (phospho Ser505) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
cPLA2 (phospho Ser505) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Cytosolic phospholipase A2 antibody, cPLA2 antibody, Phospholipase A2 group IVA antibody
|Protein names|| |
Cytosolic phospholipase A2 , cPLA2 , Phospholipase A2 group IVA
|Protein function|| |
Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response. / Phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate. / 2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate. / Stimulated by agonists such as ATP, EGF, thrombin and bradykinin as well as by cytosolic Ca2+. / 2.7 µmol/min/mg enzyme for the phospholipase A2 reaction / 4.6 µmol/min/mg enzyme for the lysophosphatase reaction
|Protein tissue specificity|| |
Expressed in various tissues such as macrophages, platelets, neutrophils, fibroblasts and lung endothelium.
|Involvement in disease|| |
Note: PLA2G4A mutations resulting in phospholipase A2 deficiency have been found in a patient affected by recurrent episodes of multiple complicated ulcers of the small intestine, not due to cyclooxygenase inhibitors use. Disease features also include platelet dysfunction, and globally decreased eicosanoid synthesis (PubMed:18451993). .
|Protein sequence and domain|| |
The N-terminal C2 domain associates with lipid membranes upon calcium binding. It modulates enzyme activity by presenting the active site to its substrate in response to elevations of cytosolic Ca2+. / Contains 1 C2 domain. / Contains 1 PLA2c domain.
|Protein post-translational modifications|| |
Activated by phosphorylation at both Ser-505 and Ser-727.
|Protein cellular localization|| |
Cytoplasm / Cytoplasmic vesicle
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St John’s Laboratory Ltd.
|Product type|| |
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