Rabbit Polyclonal Phospho-CREB-2 (S219) antibody (STJ90663)

$99.00$319.00

Reactivity: Human, Mouse
Applications: WB, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Rabbit Polyclonal Phospho-CREB-2 (S219) antibody (STJ90663)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, ELISA

Recommended dilution: WB 1:500-1:2000; ELISA 1:10000;

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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ATF4 antibody, CREB2 antibody, TXREB antibody,|Activating transcription factor 4 antibody|ATF 4 antibody|ATF4 antibody|ATF4 protein antibody|ATF4_HUMAN antibody|cAMP-dependent transcription factor ATF-4 antibody|cAMP-responsive element-binding protein 2 antibody|CREB 2 antibody|CREB-2 antibody|CREB2 antibody|Cyclic AMP dependent transcription factor ATF 4 antibody|Cyclic AMP response element binding protein 2 antibody|Cyclic AMP-dependent transcription factor ATF-4 antibody|Cyclic AMP-responsive element-binding protein 2 antibody|DNA binding protein TAXREB67 antibody|DNA-binding protein TAXREB67 antibody|Tax Responsive Enhancer Element B67 antibody|Tax-responsive enhancer element-binding protein 67 antibody|TaxREB67 antibody|TXREB antibody|Anti-ATF-4 antibody [EPR18111] (ab184909)
SCBT cat No: sc-390063|sc-7583|sc-200|sc-22800|sc-514635|

 

Name

CREB-2 (phospho Ser219) Polyclonal Antibody

Catalogue No.

STJ90663

Reactivity

Human, Mouse

Specificity

Phospho-CREB-2 (S219) Polyclonal Antibody detects endogenous levels of CREB-2 protein only when phosphorylated at S219.

Immunogen

Synthesized phospho-peptide derived from CREB-2 (phospho Ser219) at AA range 160-240

Host

Rabbit

Applications

WB, ELISA

Recommended dilution

WB 1:500-1:2000; ELISA 1:10000;

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

38 kDa

Formulation

CREB-2 (phospho Ser219) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

CREB-2 (phospho Ser219) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Cyclic AMP-dependent transcription factor ATF-4 antibody, cAMP-dependent transcription factor ATF-4 antibody, Activating transcription factor 4 antibody, Cyclic AMP-responsive element-binding protein 2 antibody, CREB-2 antibody, cAMP-responsive element-binding protein 2 antibody, DNA-binding protein TAXREB67 antibody, Tax-responsive enhancer element-binding protein 67 antibody, TaxREB67 antibody

Database links

Human UniProt/Swiss-Prot:P18848;Mouse UniPort/Swiss-Prot: Q06507;Rat UniProt/Swiss-Port: Q9ES19;Human Entrez Gene: 468;Mouse Entrez Gene: 11911;Rat Entrez Gene: Rn.2423

Protein names

Cyclic AMP-dependent transcription factor ATF-4 , cAMP-dependent transcription factor ATF-4 , Activating transcription factor 4 , Cyclic AMP-responsive element-binding protein 2 , CREB-2 , cAMP-responsive element-binding protein 2 , DNA-binding protein TAXREB67 , Tax-responsive enhancer element-binding protein 67 , TaxREB67

Protein function

Transcriptional activator. Binds the cAMP response element (CRE) (consensus: 5′-GTGACGT[AC][AG]-3′), a sequence present in many viral and cellular promoters. Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production (By similarity). It binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I. Regulates the induction of DDIT3/CHOP and asparagine synthetase (ASNS) in response to endoplasmic reticulum (ER) stress. In concert with DDIT3/CHOP, activates the transcription of TRIB3 and promotes ER stress-induced neuronal apoptosis by regulating the transcriptional induction of BBC3/PUMA. Activates transcription of SIRT4. Regulates the circadian expression of the core clock component PER2 and the serotonin transporter SLC6A4. Binds in a circadian time-dependent manner to the cAMP response elements (CRE) in the SLC6A4 and PER2 promoters and periodically activates the transcription of these genes. During ER stress response, activates the transcription of NLRP1, possibly in concert with other factors .

Protein sequence and domain

The BetaTrCP degron motif promotes binding to BTRC when phosphorylated. / Belongs to the bZIP family. / Contains 1 bZIP (basic-leucine zipper) domain.

Protein post-translational modifications

Ubiquitinated by SCF(BTRC) in response to mTORC1 signal, followed by proteasomal degradation and leading to down-regulate expression of SIRT4. / Phosphorylated by NEK6 (By similarity). Phosphorylated on the betaTrCP degron motif at Ser-219, followed by phosphorylation at Thr-213, Ser-224, Ser-231, Ser-235 and Ser-248, promoting interaction with BTRC and ubiquitination. Phosphorylation is promoted by mTORC1 (By similarity). / Phosphorylated by NEK6.

Protein cellular localization

Cytoplasm / Cell membrane / Nucleus / Cytoplasm > cytoskeleton > microtubule organizing center > centrosome

Research area

All research areas>Transcription Regulators>CREB-2
(View all antibody categories related to Transcription Regulators)

Note

AntibodyPlus can customize CREB-2 (phospho Ser219) Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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