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Rabbit Polyclonal Phospho-CREB1-S142 antibody (AP0334)
Supplier: ABclonal Inc.
Recommended applications: IHC
IHC 1:50 – 1:100
Recommended protocols: check protocols
Click or hover above images to see image description for Rabbit Polyclonal Phospho-CREB1-S142 antibody.
Check alternative names for the antibodyExpand
Active transcription factor CREB antibody|Extracellular signal-regulated kinase 2 antibody|HS44KDAP antibody|HUMKER1A antibody|Insulin stimulated MAP2 kinase antibody|MAP kinase 1 antibody|MAP kinase 2 antibody|MAP kinase 3 antibody|MAP kinase isoform p42 antibody|MAP kinase isoform p44 antibody|MAPK 1 antibody|MAPK 2 antibody|Mapk1 antibody|MAPK2 antibody|MAPK3 antibody|Microtubule associated protein 2 kinase antibody|Mitogen activated protein kinase 3 antibody|Mitogen-activated protein kinase 1 antibody|Mitogen-activated protein kinase 2 antibody|MK01_HUMAN antibody|p38 antibody|p40 antibody|p41 antibody|p41mapk antibody|p42-MAPK antibody|P42MAPK antibody|p44 ERK1 antibody|p44 MAPK antibody|P44ERK1 antibody|P44MAPK antibody|PRKM1 antibody|PRKM2 antibody|PRKM3 antibody|Protein tyrosine kinase ERK2 antibody|Transactivator protein antibody|Phospho anti-CREB (S133) antibody [E113] (ab32096)
SCBT cat No: sc-58|sc-271|sc-186|sc-377154|sc-374227|sc-25785|sc-240|sc-390063|sc-7583|
Rabbit Polyclonal Phospho-CREB1-S142 antibody
|Catalogue No.|| |
Human, Mouse, Rat
A phospho specific peptide corresponding to residues surrounding S142 of human CREB1
|Recommended dilution|| |
IHC 1:50 – 1:100
|Molecular weight|| |
Phospho-CREB1-S142 antibody was tube-contained.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Alternative antibody names|| |
|Database links|| |
Human UniProt/Swiss-Prot:<a href="http://www.uniprot.org/uniprot/P16220">P16220</a>
|Protein names|| |
|Protein function|| |
Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells.
|Protein sequence and domain|| |
Belongs to the bZIP family.; Contains 1 bZIP (basic-leucine zipper) domain.; Contains 1 KID (kinase-inducible) domain.
|Protein post-translational modifications|| |
Stimulated by phosphorylation. Phosphorylation of both Ser-133 and Ser-142 in the SCN regulates the activity of CREB and participates in circadian rhythm generation. Phosphorylation of Ser-133 allows CREBBP binding. In liver, phosphorylation is induced by fasting or glucagon in a circadian fashion (By similarity). CREBL2 positively regulates phosphorylation at Ser-133 thereby stimulating CREB1 transcriptional activity (By similarity). Phosphorylated upon calcium influx by CaMK4 and CaMK2 on Ser-133. CaMK4 is much more potent than CaMK2 in activating CREB. Phosphorylated by CaMK2 on Ser-142. Phosphorylation of Ser-142 blocks CREB-mediated transcription even when Ser-133 is phosphorylated. Phosphorylated by CaMK1 (By similarity). Phosphorylation of Ser-271 by HIPK2 in response to genotoxic stress promotes CREB1 activity, facilitating the recruitment of the coactivator CBP. Phosphorylated at Ser-133 by RPS6KA3, RPS6KA4 and RPS6KA5 in response to mitogenic or stress stimuli.; Sumoylated with SUMO1. Sumoylation on Lys-304, but not on Lys-285, is required for nuclear localization of this protein. Sumoylation is enhanced under hypoxia, promoting nuclear localization and stabilization.
|Protein cellular localization|| |
This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Alternate splicing of this gene results in two transcript variants encoding different isoforms.
|Research area|| |
<a href="http://antibodyplus.com/research-areas/">All research areas</a>><a href="http://antibodyplus.com/Kinases-and-Phosphatases/">Kinases and Phosphatases</a>><a href="http://antibodyplus.com/product-tag/Akt/">Akt</a><br><a href="http://antibodyplus.com/product-tag/Kinases-and-Phosphatases/"> (View all antibody categories related to Kinases and Phosphatases)</a>
AntibodyPlus can customize Phospho-CREB1-S142 antibody according to your requirement, including bulk product size,etc. Please contact email@example.com. AntibodyPlus provides antibody trial sample for your own antibody validation.
|Product type|| |
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