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Rabbit Polyclonal Phospho-Csk (S364) antibody (STJ90456)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IHC, ELISA
Recommended dilution: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:10000;
Recommended protocols: check protocols
Click or hover above images to see image description for Csk (phospho Ser364) Polyclonal Antibody.
Check alternative names for the antibodyExpand
CSK antibody,|C SRC antibody|C SRC kinase antibody|C src Tyrosine Kinase antibody|C-SRC kinase antibody|c-src tyrosine kinase antibody|Csk A antibody|CSK antibody|CSK_HUMAN antibody|CYTOPLASMIC TYROSINE KINASE antibody|EC 22.214.171.124 antibody|MGC112926 antibody|MGC117393 antibody|MGC154049 antibody|P60 Src antibody|Protein tyrosine kinase CYL antibody|Protein-tyrosine kinase CYL antibody|Proto oncogene tyrosine protein kinase antibody|Tyrosine protein kinase CSK antibody|Tyrosine-protein kinase CSK antibody|zgc:154049 antibody|Anti-CSK antibody (ab744)
SCBT cat No: sc-166513|sc-286|sc-51580|sc-166560|sc-13074|sc-9897|
Csk (phospho Ser364) Polyclonal Antibody
|Catalogue No.|| |
Human, Mouse, Rat
Phospho-Csk (S364) Polyclonal Antibody detects endogenous levels of Csk protein only when phosphorylated at S364.
Synthesized phospho-peptide derived from Csk (phospho Ser364) at AA range 300-380
WB, IHC, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:10000;
|Molecular weight|| |
Csk (phospho Ser364) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Csk (phospho Ser364) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Tyrosine-protein kinase CSK antibody, C-Src kinase antibody, Protein-tyrosine kinase CYL antibody
|Protein names|| |
Tyrosine-protein kinase CSK , C-Src kinase , Protein-tyrosine kinase CYL
|Protein function|| |
Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T-cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK. / ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. / Mg2+
|Protein tissue specificity|| |
Expressed in lung and macrophages.
|Protein sequence and domain|| |
The architecture of this protein is similar to that of Src-family kinases (SFKs) with one N-terminal SH3 domain, one SH2 domain, and a C-terminal kinase domain. / Belongs to the protein kinase superfamily. Tyr protein kinase family. CSK subfamily. / Contains 1 protein kinase domain. / Contains 1 SH2 domain. / Contains 1 SH3 domain.
|Protein post-translational modifications|| |
Phosphorylated at Ser-364 by PKA, leading to increased activity. Autophosphorylated.
|Protein cellular localization|| |
Cytoplasm / Cell membrane
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St John’s Laboratory Ltd.
|Product type|| |
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