Rabbit Polyclonal Phospho-CSN1 (S454) antibody (STJ91250)

$99.00$319.00

Reactivity: Human, Mouse, Rat
Applications: IHC, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Rabbit Polyclonal Phospho-CSN1 (S454) antibody (STJ91250)

Supplier: St John’s Laboratory Ltd.

Recommended applications: IHC, ELISA

Recommended dilution: IHC 1:100-1:300; ELISA 1:5000;

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for CSN1 (phospho Ser454) Polyclonal Antibody.

Alternative names:

Check alternative names for the antibody

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GPS1 antibody, COPS1 antibody, CSN1 antibody,|COP9 signalosome complex subunit 1 antibody|COP9 signalosome subunit 1 antibody|COPS1 antibody|CSN 1 antibody|CSN1_HUMAN antibody|FUS6/COP11, Arabidopsis, homolog of antibody|G protein pathway suppressor 1 antibody|GPS-1 antibody|Gps1 antibody|JAB1-containing signalosome subunit 1 antibody|Protein GPS1 antibody|Protein MFH antibody|SGN1 antibody|Signalosome subunit 1 antibody|Anti-CSN1 antibody [EP15642-22] (ab194359)
SCBT cat No: sc-365617|sc-514086|sc-377134|sc-292637|sc-47854|sc-47856|

 

Name

CSN1 (phospho Ser454) Polyclonal Antibody

Catalogue No.

STJ91250

Reactivity

Human, Mouse, Rat

Specificity

Phospho-CSN1 (S454) Polyclonal Antibody detects endogenous levels of CSN1 protein only when phosphorylated at S454.

Immunogen

Synthesized phospho-peptide derived from CSN1 (phospho Ser454) at AA range 390-470

Host

Rabbit

Applications

IHC, ELISA

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

53.372 kDa

Formulation

CSN1 (phospho Ser454) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

CSN1 (phospho Ser454) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

COP9 signalosome complex subunit 1 antibody, SGN1 antibody, Signalosome subunit 1 antibody, G protein pathway suppressor 1 antibody, GPS-1 antibody, JAB1-containing signalosome subunit 1 antibody, Protein MFH antibody

Protein names

COP9 signalosome complex subunit 1 , SGN1 , Signalosome subunit 1 , G protein pathway suppressor 1 , GPS-1 , JAB1-containing signalosome subunit 1 , Protein MFH

Protein function

Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction.

Protein tissue specificity

Widely expressed.

Protein sequence and domain

The PCI domain is necessary and sufficient for the interactions with other CSN subunits of the complex. Mediates the interaction with CAPN8 (By similarity). / The N-terminal part (1-216), which is not required for deneddylating activity and CSN complex formation, is nevertheless essential for other aspects of CSN complex function, such as repression of c-fos/FOS expression. / Belongs to the CSN1 family. / Contains 1 PCI domain.

Protein cellular localization

Cytoplasm / Nucleus

Research area

<a href="http://antibodyplus.com/research-areas/">All research areas</a>><a href="http://antibodyplus.com/Signaling-Intermediates/">Signaling Intermediates</a>><a href="http://antibodyplus.com/product-tag/CSN1/">CSN1</a><br><a href="http://antibodyplus.com/product-tag/Signaling-Intermediates/"&gt; (View all antibody categories related to Signaling Intermediates)</a>

Note

AntibodyPlus can customize CSN1 (phospho Ser454) Antibody according to your requirement, including bulk product size,etc. Please contact <a href="mailto:info@antibodyplus.com">info@antibodyplus.com</a>. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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