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Rabbit Polyclonal Phospho-CSN1 (S454) antibody (STJ91250)
Supplier: St John’s Laboratory Ltd.
Recommended applications: IHC, ELISA
Recommended dilution: IHC 1:100-1:300; ELISA 1:5000;
Recommended protocols: check protocols
Click or hover above images to see image description for CSN1 (phospho Ser454) Polyclonal Antibody.
Check alternative names for the antibodyExpand
GPS1 antibody, COPS1 antibody, CSN1 antibody,|COP9 signalosome complex subunit 1 antibody|COP9 signalosome subunit 1 antibody|COPS1 antibody|CSN 1 antibody|CSN1_HUMAN antibody|FUS6/COP11, Arabidopsis, homolog of antibody|G protein pathway suppressor 1 antibody|GPS-1 antibody|Gps1 antibody|JAB1-containing signalosome subunit 1 antibody|Protein GPS1 antibody|Protein MFH antibody|SGN1 antibody|Signalosome subunit 1 antibody|Anti-CSN1 antibody [EP15642-22] (ab194359)
SCBT cat No: sc-365617|sc-514086|sc-377134|sc-292637|sc-47854|sc-47856|
CSN1 (phospho Ser454) Polyclonal Antibody
|Catalogue No.|| |
Human, Mouse, Rat
Phospho-CSN1 (S454) Polyclonal Antibody detects endogenous levels of CSN1 protein only when phosphorylated at S454.
Synthesized phospho-peptide derived from CSN1 (phospho Ser454) at AA range 390-470
|Recommended dilution|| |
IHC 1:100-1:300; ELISA 1:5000;
|Molecular weight|| |
CSN1 (phospho Ser454) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
CSN1 (phospho Ser454) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
COP9 signalosome complex subunit 1 antibody, SGN1 antibody, Signalosome subunit 1 antibody, G protein pathway suppressor 1 antibody, GPS-1 antibody, JAB1-containing signalosome subunit 1 antibody, Protein MFH antibody
|Protein names|| |
COP9 signalosome complex subunit 1 , SGN1 , Signalosome subunit 1 , G protein pathway suppressor 1 , GPS-1 , JAB1-containing signalosome subunit 1 , Protein MFH
|Protein function|| |
Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction.
|Protein tissue specificity|| |
|Protein sequence and domain|| |
The PCI domain is necessary and sufficient for the interactions with other CSN subunits of the complex. Mediates the interaction with CAPN8 (By similarity). / The N-terminal part (1-216), which is not required for deneddylating activity and CSN complex formation, is nevertheless essential for other aspects of CSN complex function, such as repression of c-fos/FOS expression. / Belongs to the CSN1 family. / Contains 1 PCI domain.
|Protein cellular localization|| |
Cytoplasm / Nucleus
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St John’s Laboratory Ltd.
|Product type|| |
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