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Rabbit Polyclonal Phospho-Cyclin C (S275) antibody (STJ90976)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IHC, ELISA
Recommended dilution: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:10000;
Recommended protocols: check protocols
Click or hover above images to see image description for Cyclin C (phospho Ser275) Polyclonal Antibody.
Check alternative names for the antibodyExpand
CCNC antibody,|ccnc antibody|CCNC_HUMAN antibody|CycC antibody|Cyclin C antibody|Cyclin-C antibody|hSRB11 antibody|OTTHUMP00000016897 antibody|SRB11 homolog antibody|Phospho anti-Cyclin C (S275) antibody (ab78868)
SCBT cat No: sc-1061|
Cyclin C (phospho Ser275) Polyclonal Antibody
|Catalogue No.|| |
Human, Mouse, Rat
Phospho-Cyclin C (S275) Polyclonal Antibody detects endogenous levels of Cyclin C protein only when phosphorylated at S275.
Synthesized phospho-peptide derived from Cyclin C (phospho Ser275) at AA range 210-290
WB, IHC, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:10000;
|Molecular weight|| |
Cyclin C (phospho Ser275) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Cyclin C (phospho Ser275) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Cyclin-C antibody, SRB11 homolog antibody, hSRB11 antibody
|Protein names|| |
Cyclin-C , SRB11 homolog , hSRB11
|Protein function|| |
Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex.
|Protein tissue specificity|| |
Highest levels in pancreas. High levels in heart, liver, skeletal muscle and kidney. Low levels in brain.
|Protein sequence and domain|| |
Belongs to the cyclin family. Cyclin C subfamily. / Contains 1 cyclin N-terminal domain.
|Protein cellular localization|| |
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St John’s Laboratory Ltd.
|Product type|| |
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