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Rabbit Polyclonal Phospho-Cyclin D2 (T280) antibody (STJ90627)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IHC, ELISA
Recommended dilution: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:10000;
Recommended protocols: check protocols
Click or hover above images to see image description for Cyclin D2 (phospho Thr280) Polyclonal Antibody.
Check alternative names for the antibodyExpand
CCND2 antibody,|CCND 2 antibody|ccnd2 antibody|CCND2_HUMAN antibody|CyclinD2 antibody|G1/S specific cyclin D2 antibody|G1/S-specific cyclin-D2 antibody|KIAK0002 antibody|MGC102758 antibody|Anti-Cyclin D2 antibody [DCS-3.1] (ab3085)
SCBT cat No: sc-593|
Cyclin D2 (phospho Thr280) Polyclonal Antibody
|Catalogue No.|| |
Human, Mouse, Rat
Phospho-Cyclin D2 (T280) Polyclonal Antibody detects endogenous levels of Cyclin D2 protein only when phosphorylated at T280.
Synthesized phospho-peptide derived from Cyclin D2 (phospho Thr280) at AA range 220-300
WB, IHC, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:10000;
|Molecular weight|| |
Cyclin D2 (phospho Thr280) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Cyclin D2 (phospho Thr280) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
G1/S-specific cyclin-D2 antibody
|Protein names|| |
|Protein function|| |
Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Hypophosphorylates RB1 in early G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D2/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (By similarity).
|Involvement in disease|| |
Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 3 (MPPH3) [MIM:615938]: A syndrome characterized by megalencephaly, ventriculomegaly that may lead to hydrocephalus, and polymicrogyria; polydactyly may also be seen. There is considerable phenotypic similarity between this disorder and the megalencephaly-capillary malformation syndrome. . Note: The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Belongs to the cyclin family. Cyclin D subfamily. / Contains 1 cyclin N-terminal domain.
|Protein post-translational modifications|| |
Polyubiquitinated by the SCF(FBXL2) complex, leading to proteasomal degradation.
|Protein cellular localization|| |
Nucleus / Cytoplasm / Membrane / Cytoplasm
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St John’s Laboratory Ltd.
|Product type|| |
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