Rabbit Polyclonal Phospho-Cyclin D2 (T280) antibody (STJ90627)

$99.00$319.00

Reactivity: Human, Mouse, Rat
Applications: WB, IHC, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Rabbit Polyclonal Phospho-Cyclin D2 (T280) antibody (STJ90627)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, IHC, ELISA

Recommended dilution: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:10000;

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Cyclin D2 (phospho Thr280) Polyclonal Antibody.

Alternative names:

Check alternative names for the antibody

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CCND2 antibody,|CCND 2 antibody|ccnd2 antibody|CCND2_HUMAN antibody|CyclinD2 antibody|G1/S specific cyclin D2 antibody|G1/S-specific cyclin-D2 antibody|KIAK0002 antibody|MGC102758 antibody|Anti-Cyclin D2 antibody [DCS-3.1] (ab3085)
SCBT cat No: sc-593|

 

Name

Cyclin D2 (phospho Thr280) Polyclonal Antibody

Catalogue No.

STJ90627

Reactivity

Human, Mouse, Rat

Specificity

Phospho-Cyclin D2 (T280) Polyclonal Antibody detects endogenous levels of Cyclin D2 protein only when phosphorylated at T280.

Immunogen

Synthesized phospho-peptide derived from Cyclin D2 (phospho Thr280) at AA range 220-300

Host

Rabbit

Applications

WB, IHC, ELISA

Recommended dilution

WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:10000;

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

40 kDa

Formulation

Cyclin D2 (phospho Thr280) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

Cyclin D2 (phospho Thr280) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

G1/S-specific cyclin-D2 antibody

Database links

Human UniProt/Swiss-Prot:P30279;Mouse UniPort/Swiss-Prot: P30280;Rat UniProt/Swiss-Port: Q04827;Human Entrez Gene: 894;Mouse Entrez Gene: 12444;Rat Entrez Gene: Rn.96083

Protein names

G1/S-specific cyclin-D2

Protein function

Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Hypophosphorylates RB1 in early G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D2/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (By similarity).

Involvement in disease

Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 3 (MPPH3) [MIM:615938]: A syndrome characterized by megalencephaly, ventriculomegaly that may lead to hydrocephalus, and polymicrogyria; polydactyly may also be seen. There is considerable phenotypic similarity between this disorder and the megalencephaly-capillary malformation syndrome. . Note: The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

Belongs to the cyclin family. Cyclin D subfamily. / Contains 1 cyclin N-terminal domain.

Protein post-translational modifications

Polyubiquitinated by the SCF(FBXL2) complex, leading to proteasomal degradation.

Protein cellular localization

Nucleus / Cytoplasm / Membrane / Cytoplasm

Research area

All research areas>Cell Cycle Proteins>Cyclin
(View all antibody categories related to Cell Cycle Proteins)

Note

AntibodyPlus can customize Cyclin D2 (phospho Thr280) Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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