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Rabbit Polyclonal Phospho-Cytokeratin 18 (S52) antibody (STJ90707)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IHC, IF, ELISA
Recommended dilution: WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:10000;
Recommended protocols: check protocols
Click or hover above images to see image description for Cytokeratin 18 (phospho Ser52) Polyclonal Antibody.
Check alternative names for the antibodyExpand
KRT18 antibody, CYK18 antibody, PIG46 antibody,|Cell proliferation inducing gene 46 protein antibody|Cell proliferation inducing protein 46 antibody|Cell proliferation-inducing gene 46 protein antibody|CK 18 antibody|CK-18 antibody|CK18 antibody|CYK 18 antibody|CYK18 antibody|Cytokeratin 18 antibody|Cytokeratin endo B antibody|Cytokeratin-18 antibody|K 18 antibody|K18 antibody|K1C18_HUMAN antibody|KA18 antibody|Keratin 18 antibody|Keratin 18, type I antibody|Keratin D antibody|keratin, type I cytoskeletal 18 antibody|Keratin-18 antibody|Krt18 antibody|Anti-Cytokeratin 18 antibody [C-04] (ab668)
SCBT cat No: sc-53254|sc-377224|sc-271937|sc-53255|sc-70915|sc-393091|sc-58726|sc-393002|sc-366511|sc-101461|sc-101931|sc-70917|sc-58727|sc-398871|sc-51582|sc-51583|sc-6259|sc-28264|sc-53256|sc-31700|sc-31701|sc-32722|
Cytokeratin 18 (phospho Ser52) Polyclonal Antibody
|Catalogue No.|| |
Phospho-Cytokeratin 18 (S52) Polyclonal Antibody detects endogenous levels of Cytokeratin 18 protein only when phosphorylated at S52.
Synthesized phospho-peptide derived from Cytokeratin 18 (phospho Ser52) at AA range 40-120
WB, IHC, IF, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:10000;
|Molecular weight|| |
Cytokeratin 18 (phospho Ser52) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Cytokeratin 18 (phospho Ser52) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Keratin, type I cytoskeletal 18 antibody, Cell proliferation-inducing gene 46 protein antibody, Cytokeratin-18 antibody, CK-18 antibody, Keratin-18 antibody, K18 antibody
|Protein names|| |
Keratin, type I cytoskeletal 18 , Cell proliferation-inducing gene 46 protein , Cytokeratin-18 , CK-18 , Keratin-18 , K18
|Protein function|| |
Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection.
|Protein tissue specificity|| |
Expressed in colon, placenta, liver and very weakly in exocervix. Increased expression observed in lymph nodes of breast carcinoma.
|Involvement in disease|| |
Cirrhosis (CIRRH) [MIM:215600]: A liver disease characterized by severe panlobular liver-cell swelling with Mallory body formation, prominent pericellular fibrosis, and marked deposits of copper. Clinical features include abdomen swelling, jaundice and pulmonary hypertension. . Note: The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Belongs to the intermediate filament family.
|Protein post-translational modifications|| |
Phosphorylation at Ser-34 increases during mitosis. Hyperphosphorylated at Ser-53 in diseased cirrhosis liver. Phosphorylation increases by IL-6. / Proteolytically cleaved by caspases during epithelial cell apoptosis. Cleavage occurs at Asp-238 by either caspase-3, caspase-6 or caspase-7. / O-GlcNAcylation increases solubility, and decreases stability by inducing proteasomal degradation.
|Protein cellular localization|| |
Cytoplasm > perinuclear region / Nucleus > nucleolus
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St John’s Laboratory Ltd.
|Product type|| |
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