Rabbit Polyclonal Phospho-Dematin (S403) antibody (STJ90897)

$99.00$319.00

Reactivity: Human, Mouse
Applications: WB, IHC, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

Clear
-$50 as credit for submitting review for primary antibody
Shipping notice:
Product will be delivered in 6 to 8 Business Days

Rabbit Polyclonal Phospho-Dematin (S403) antibody (STJ90897)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, IHC, ELISA

Recommended dilution: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:10000;

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Dematin (phospho Ser403) Polyclonal Antibody.

Alternative names:

Check alternative names for the antibody

Expand

DMTN antibody, DMT antibody, EPB49 antibody,|DEMA antibody|DEMA_HUMAN antibody|Dematin antibody|DMT antibody|EPB49 antibody|erythrocyte membrane protein band 4.9 (dematin) antibody|Erythrocyte membrane protein band 4.9 antibody|Anti-Dematin antibody – C-terminal (ab182249)
SCBT cat No: To be updated

 

Name

Dematin (phospho Ser403) Polyclonal Antibody

Catalogue No.

STJ90897

Reactivity

Human, Mouse

Specificity

Phospho-Dematin (S403) Polyclonal Antibody detects endogenous levels of Dematin protein only when phosphorylated at S403.

Immunogen

Synthesized phospho-peptide derived from Dematin (phospho Ser403) at AA range 330-410

Host

Rabbit

Applications

WB, IHC, ELISA

Recommended dilution

WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:10000;

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

55 kDa

Formulation

Dematin (phospho Ser403) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

Dematin (phospho Ser403) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Dematin antibody, Dematin actin-binding protein antibody, Erythrocyte membrane protein band 4.9 antibody

Database links

Human UniProt/Swiss-Prot:Q08495;Mouse UniPort/Swiss-Prot: Q9WV69;Rat UniProt/Swiss-Port: D4A559;Human Entrez Gene: 2039;Mouse Entrez Gene: 13829;Rat Entrez Gene: Rn.9618

Protein names

Dematin , Dematin actin-binding protein , Erythrocyte membrane protein band 4.9

Protein function

Membrane-cytoskeleton-associated protein with F-actin-binding activity that induces F-actin bundles formation and stabilization. Its F-actin-bundling activity is reversibly regulated upon its phosphorylation by the cAMP-dependent protein kinase A (PKA). Binds to the erythrocyte membrane glucose transporter-1 SLC2A1/GLUT1, and hence stabilizes and attaches the spectrin-actin network to the erythrocytic plasma membrane. Plays a role in maintaining the functional integrity of PKA-activated erythrocyte shape and the membrane mechanical properties. Plays also a role as a modulator of actin dynamics in fibroblasts; acts as a negative regulator of the RhoA activation pathway. In platelets, functions as a regulator of internal calcium mobilization across the dense tubular system that affects platelet granule secretion pathways and aggregation. Also required for the formation of a diverse set of cell protrusions, such as filopodia and lamellipodia, necessary for platelet cell spreading, motility and migration. Acts as a tumor suppressor and inhibits malignant cell transformation.

Protein tissue specificity

Expressed in platelets (at protein level). Expressed in heart, brain, lung, skeletal muscle, and kidney.

Protein sequence and domain

Both the N-terminal core domain and the C-terminal headpiece domain are sufficient for binding to F-actin and necessary for actin bundling activity. / Belongs to the villin/gelsolin family. / Contains 1 HP (headpiece) domain.

Protein post-translational modifications

Phosphorylated. Phosphorylation at Ser-403 by PKA causes the C-terminal headpiece domain to associate with the N-terminal core domain, and leads to the inhibition of its actin bundling activity. / The N-terminus is blocked.

Protein cellular localization

Cytoplasm / Cytoplasm > cytosol / Cytoplasm > perinuclear region / Cytoplasm > cytoskeleton / Cell membrane / Membrane / Endomembrane system / Cell projection

Note

AntibodyPlus can customize Dematin (phospho Ser403) Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

Reviews


There are no reviews yet.

Only logged in customers who have purchased this product may leave a review

There are no reviews for this product yet.
By submitting a review, get following benefits:

1. Receive $50 ABcoins as credit for each review.
2. First trial sample order will be fully refunded as credit.
3. Have a chance to win a $50 amazon gift card!

view database submit reviews

There is no extra validation for this product yet.
Check other extra validated antibodies below:



Welcome to AntibodyPlus!