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Rabbit Polyclonal Phospho-Dematin (S403) antibody (STJ90897)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IHC, ELISA
Recommended dilution: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:10000;
Recommended protocols: check protocols
Click or hover above images to see image description for Dematin (phospho Ser403) Polyclonal Antibody.
Check alternative names for the antibodyExpand
DMTN antibody, DMT antibody, EPB49 antibody,|DEMA antibody|DEMA_HUMAN antibody|Dematin antibody|DMT antibody|EPB49 antibody|erythrocyte membrane protein band 4.9 (dematin) antibody|Erythrocyte membrane protein band 4.9 antibody|Anti-Dematin antibody – C-terminal (ab182249)
SCBT cat No: To be updated
Dematin (phospho Ser403) Polyclonal Antibody
|Catalogue No.|| |
Phospho-Dematin (S403) Polyclonal Antibody detects endogenous levels of Dematin protein only when phosphorylated at S403.
Synthesized phospho-peptide derived from Dematin (phospho Ser403) at AA range 330-410
WB, IHC, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:10000;
|Molecular weight|| |
Dematin (phospho Ser403) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dematin (phospho Ser403) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Dematin antibody, Dematin actin-binding protein antibody, Erythrocyte membrane protein band 4.9 antibody
|Protein names|| |
Dematin , Dematin actin-binding protein , Erythrocyte membrane protein band 4.9
|Protein function|| |
Membrane-cytoskeleton-associated protein with F-actin-binding activity that induces F-actin bundles formation and stabilization. Its F-actin-bundling activity is reversibly regulated upon its phosphorylation by the cAMP-dependent protein kinase A (PKA). Binds to the erythrocyte membrane glucose transporter-1 SLC2A1/GLUT1, and hence stabilizes and attaches the spectrin-actin network to the erythrocytic plasma membrane. Plays a role in maintaining the functional integrity of PKA-activated erythrocyte shape and the membrane mechanical properties. Plays also a role as a modulator of actin dynamics in fibroblasts; acts as a negative regulator of the RhoA activation pathway. In platelets, functions as a regulator of internal calcium mobilization across the dense tubular system that affects platelet granule secretion pathways and aggregation. Also required for the formation of a diverse set of cell protrusions, such as filopodia and lamellipodia, necessary for platelet cell spreading, motility and migration. Acts as a tumor suppressor and inhibits malignant cell transformation.
|Protein tissue specificity|| |
Expressed in platelets (at protein level). Expressed in heart, brain, lung, skeletal muscle, and kidney.
|Protein sequence and domain|| |
Both the N-terminal core domain and the C-terminal headpiece domain are sufficient for binding to F-actin and necessary for actin bundling activity. / Belongs to the villin/gelsolin family. / Contains 1 HP (headpiece) domain.
|Protein post-translational modifications|| |
Phosphorylated. Phosphorylation at Ser-403 by PKA causes the C-terminal headpiece domain to associate with the N-terminal core domain, and leads to the inhibition of its actin bundling activity. / The N-terminus is blocked.
|Protein cellular localization|| |
Cytoplasm / Cytoplasm > cytosol / Cytoplasm > perinuclear region / Cytoplasm > cytoskeleton / Cell membrane / Membrane / Endomembrane system / Cell projection
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St John’s Laboratory Ltd.
|Product type|| |
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