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Rabbit Polyclonal Phospho-Dok-1 (Y398) antibody (STJ90683)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-1:2000; ELISA 1:20000;
Recommended protocols: check protocols
Click or hover above images to see image description for Dok-1 (phospho Tyr398) Polyclonal Antibody.
Check alternative names for the antibodyExpand
DOK1 antibody,|Docking protein 1 62kD antibody|Docking protein 1 antibody|DOK 1 antibody|DOK1 antibody|DOK1_HUMAN antibody|Downstream of tyrosine kinase 1 antibody|p62(dok) antibody|P62DOK antibody|pp62 antibody|Anti-DOK1 antibody (ab8112)
SCBT cat No: sc-135888|sc-6929|sc-46093|sc-6277|sc-6934|sc-135889|
Dok-1 (phospho Tyr398) Polyclonal Antibody
|Catalogue No.|| |
Human, Mouse, Rat
Phospho-Dok-1 (Y398) Polyclonal Antibody detects endogenous levels of Dok-1 protein only when phosphorylated at Y398.
Synthesized phospho-peptide derived from Dok-1 (phospho Tyr398) at AA range 340-420
|Recommended dilution|| |
WB 1:500-1:2000; ELISA 1:20000;
|Molecular weight|| |
Dok-1 (phospho Tyr398) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dok-1 (phospho Tyr398) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Docking protein 1 antibody, Downstream of tyrosine kinase 1 antibody, p62antibody, dok antibody, antibody, pp62 antibody
|Protein names|| |
Docking protein 1 , Downstream of tyrosine kinase 1 , p62, dok , , pp62
|Protein function|| |
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3.
|Protein tissue specificity|| |
Expressed in pancreas, heart, leukocyte and spleen. Expressed in both resting and activated peripheral blood T-cells. Expressed in breast cancer.
|Protein sequence and domain|| |
The PTB domain mediates receptor interaction. / Belongs to the DOK family. Type A subfamily. / Contains 1 IRS-type PTB domain. / Contains 1 PH domain.
|Protein post-translational modifications|| |
Constitutively tyrosine-phosphorylated. Phosphorylated by TEC (By similarity). Phosphorylated by LYN (By similarity). Phosphorylated on tyrosine residues by the insulin receptor kinase. Results in the negative regulation of the insulin signaling pathway. Phosphorylated on tyrosine residues by SRMS. / Isoform 3 contains a N-acetylmethionine at position 1.
|Protein cellular localization|| |
Cytoplasm / Nucleus / Cytoplasm > perinuclear region
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St John’s Laboratory Ltd.
|Product type|| |
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