Rabbit Polyclonal Phospho-Dok-1 (Y398) antibody (STJ90683)

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Reactivity: Human, Mouse, Rat
Applications: WB, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Rabbit Polyclonal Phospho-Dok-1 (Y398) antibody (STJ90683)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, ELISA

Recommended dilution: WB 1:500-1:2000; ELISA 1:20000;

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Dok-1 (phospho Tyr398) Polyclonal Antibody.

Alternative names:

Check alternative names for the antibody

Expand

DOK1 antibody,|Docking protein 1 62kD antibody|Docking protein 1 antibody|DOK 1 antibody|DOK1 antibody|DOK1_HUMAN antibody|Downstream of tyrosine kinase 1 antibody|p62(dok) antibody|P62DOK antibody|pp62 antibody|Anti-DOK1 antibody (ab8112)
SCBT cat No: sc-135888|sc-6929|sc-46093|sc-6277|sc-6934|sc-135889|

 

Name

Dok-1 (phospho Tyr398) Polyclonal Antibody

Catalogue No.

STJ90683

Reactivity

Human, Mouse, Rat

Specificity

Phospho-Dok-1 (Y398) Polyclonal Antibody detects endogenous levels of Dok-1 protein only when phosphorylated at Y398.

Immunogen

Synthesized phospho-peptide derived from Dok-1 (phospho Tyr398) at AA range 340-420

Host

Rabbit

Applications

WB, ELISA

Recommended dilution

WB 1:500-1:2000; ELISA 1:20000;

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

62 kDa

Formulation

Dok-1 (phospho Tyr398) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

Dok-1 (phospho Tyr398) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Docking protein 1 antibody, Downstream of tyrosine kinase 1 antibody, p62antibody, dok antibody, antibody, pp62 antibody

Database links

Human UniProt/Swiss-Prot:Q99704;Mouse UniPort/Swiss-Prot: P97465;Rat UniProt/Swiss-Port: Q4QQV2;Human Entrez Gene: 1796;Mouse Entrez Gene: 13448;Rat Entrez Gene: Rn.117974

Protein names

Docking protein 1 , Downstream of tyrosine kinase 1 , p62, dok , , pp62

Protein function

DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3.

Protein tissue specificity

Expressed in pancreas, heart, leukocyte and spleen. Expressed in both resting and activated peripheral blood T-cells. Expressed in breast cancer.

Protein sequence and domain

The PTB domain mediates receptor interaction. / Belongs to the DOK family. Type A subfamily. / Contains 1 IRS-type PTB domain. / Contains 1 PH domain.

Protein post-translational modifications

Constitutively tyrosine-phosphorylated. Phosphorylated by TEC (By similarity). Phosphorylated by LYN (By similarity). Phosphorylated on tyrosine residues by the insulin receptor kinase. Results in the negative regulation of the insulin signaling pathway. Phosphorylated on tyrosine residues by SRMS. / Isoform 3 contains a N-acetylmethionine at position 1.

Protein cellular localization

Cytoplasm / Nucleus / Cytoplasm > perinuclear region

Research area

All research areas>Signaling Intermediates>Dok
(View all antibody categories related to Signaling Intermediates)

Note

AntibodyPlus can customize Dok-1 (phospho Tyr398) Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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