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Rabbit Polyclonal Phospho-Dok-2 (Y299) antibody (STJ90245)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IF, ELISA
Recommended dilution: WB 1:500-1:2000; IF 1:200-1:1000; ELISA 1:20000;
Recommended protocols: check protocols
Click or hover above images to see image description for Dok-2 (phospho Tyr299) Polyclonal Antibody.
Check alternative names for the antibodyExpand
DOK2 antibody,|Docking protein 2 56kDa antibody|Docking protein 2 antibody|DOK 2 antibody|DOK R antibody|DOK2 antibody|DOK2_HUMAN antibody|Downstream of tyrosine kinase 2 antibody|OTTHUMP00000161710 antibody|OTTHUMP00000224923 antibody|p56(dok 2) antibody|p56(dok-2) antibody|p56dok 2 antibody|p56DOK antibody|p56dok2 antibody|Anti-DOK2 antibody (ab47507)
SCBT cat No: sc-135889|sc-271781|sc-8130|sc-17830|sc-515560|sc-13952|
Dok-2 (phospho Tyr299) Polyclonal Antibody
|Catalogue No.|| |
Human, Mouse, Monkey
Phospho-Dok-2 (Y299) Polyclonal Antibody detects endogenous levels of Dok-2 protein only when phosphorylated at Y299.
Synthesized phospho-peptide derived from Dok-2 (phospho Tyr299) at AA range 240-320
WB, IF, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IF 1:200-1:1000; ELISA 1:20000;
|Molecular weight|| |
Dok-2 (phospho Tyr299) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dok-2 (phospho Tyr299) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Docking protein 2 antibody, Downstream of tyrosine kinase 2 antibody, p56antibody, dok-2 antibody
|Protein names|| |
Docking protein 2 , Downstream of tyrosine kinase 2 , p56, dok-2
|Protein function|| |
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK2 may modulate the cellular proliferation induced by IL-4, as well as IL-2 and IL-3. May be involved in modulating Bcr-Abl signaling. Attenuates EGF-stimulated MAP kinase activation (By similarity).
|Protein tissue specificity|| |
Highly expressed in peripheral blood leukocytes, lymph nodes and spleen. Lower expression in thymus, bone marrow and fetal liver.
|Protein sequence and domain|| |
PTB domain mediates receptor interaction. / Belongs to the DOK family. Type A subfamily. / Contains 1 IRS-type PTB domain. / Contains 1 PH domain.
|Protein post-translational modifications|| |
On immunoreceptor stimulation, phosphorylated on C-terminal tyrosine residues. Phosphorylation on Tyr-345 is required for binding to the SH2 domain of NCK. Phosphorylation on both Tyr-271 and Tyr-299 is required for interaction with RASGAP. Phosphorylated on tyrosine residues by TEK/TIE2 (By similarity).
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St John’s Laboratory Ltd.
|Product type|| |
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