Rabbit Polyclonal Phospho-Dok-2 (Y299) antibody (STJ90245)

$99.00$319.00

Reactivity: Human, Mouse, Monkey
Applications: WB, IF, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Rabbit Polyclonal Phospho-Dok-2 (Y299) antibody (STJ90245)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, IF, ELISA

Recommended dilution: WB 1:500-1:2000; IF 1:200-1:1000; ELISA 1:20000;

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Dok-2 (phospho Tyr299) Polyclonal Antibody.

Alternative names:

Check alternative names for the antibody

Expand

DOK2 antibody,|Docking protein 2 56kDa antibody|Docking protein 2 antibody|DOK 2 antibody|DOK R antibody|DOK2 antibody|DOK2_HUMAN antibody|Downstream of tyrosine kinase 2 antibody|OTTHUMP00000161710 antibody|OTTHUMP00000224923 antibody|p56(dok 2) antibody|p56(dok-2) antibody|p56dok 2 antibody|p56DOK antibody|p56dok2 antibody|Anti-DOK2 antibody (ab47507)
SCBT cat No: sc-135889|sc-271781|sc-8130|sc-17830|sc-515560|sc-13952|

 

Name

Dok-2 (phospho Tyr299) Polyclonal Antibody

Catalogue No.

STJ90245

Reactivity

Human, Mouse, Monkey

Specificity

Phospho-Dok-2 (Y299) Polyclonal Antibody detects endogenous levels of Dok-2 protein only when phosphorylated at Y299.

Immunogen

Synthesized phospho-peptide derived from Dok-2 (phospho Tyr299) at AA range 240-320

Host

Rabbit

Applications

WB, IF, ELISA

Recommended dilution

WB 1:500-1:2000; IF 1:200-1:1000; ELISA 1:20000;

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

56/48 kDa

Formulation

Dok-2 (phospho Tyr299) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

Dok-2 (phospho Tyr299) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Docking protein 2 antibody, Downstream of tyrosine kinase 2 antibody, p56antibody, dok-2 antibody

Database links

Human UniProt/Swiss-Prot:O60496;Mouse UniPort/Swiss-Prot: O70469;Rat UniProt/Swiss-Port: D3ZHJ4;Human Entrez Gene: 9046;Mouse Entrez Gene: 13449;Rat Entrez Gene: Rn.126595

Protein names

Docking protein 2 , Downstream of tyrosine kinase 2 , p56, dok-2

Protein function

DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK2 may modulate the cellular proliferation induced by IL-4, as well as IL-2 and IL-3. May be involved in modulating Bcr-Abl signaling. Attenuates EGF-stimulated MAP kinase activation (By similarity).

Protein tissue specificity

Highly expressed in peripheral blood leukocytes, lymph nodes and spleen. Lower expression in thymus, bone marrow and fetal liver.

Protein sequence and domain

PTB domain mediates receptor interaction. / Belongs to the DOK family. Type A subfamily. / Contains 1 IRS-type PTB domain. / Contains 1 PH domain.

Protein post-translational modifications

On immunoreceptor stimulation, phosphorylated on C-terminal tyrosine residues. Phosphorylation on Tyr-345 is required for binding to the SH2 domain of NCK. Phosphorylation on both Tyr-271 and Tyr-299 is required for interaction with RASGAP. Phosphorylated on tyrosine residues by TEK/TIE2 (By similarity).

Research area

All research areas>Signaling Intermediates>Dok
(View all antibody categories related to Signaling Intermediates)

Note

AntibodyPlus can customize Dok-2 (phospho Tyr299) Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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