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Rabbit Polyclonal Phospho-DOK1-Y362 antibody (AP0248)
Supplier: ABclonal Inc.
Recommended applications: WB,IHC
WB 1:500 – 1:2000
IHC 1:50 – 1:100
Recommended protocols: check protocols
Click or hover above images to see image description for Rabbit Polyclonal Phospho-DOK1-Y362 antibody.
Check alternative names for the antibodyExpand
Docking protein 1 62kD antibody|Docking protein 1 antibody|DOK 1 antibody|DOK1 antibody|DOK1_HUMAN antibody|Downstream of tyrosine kinase 1 antibody|p62(dok) antibody|P62DOK antibody|pp62 antibody|Anti-DOK1 antibody (ab8112)
SCBT cat No: sc-135888|sc-6929|sc-46093|sc-6277|sc-6934|sc-135889|
Rabbit Polyclonal Phospho-DOK1-Y362 antibody
|Catalogue No.|| |
Human, Mouse, Rat
A phospho specific peptide corresponding to residues surrounding Y362 of human DOK1
|Recommended dilution|| |
WB 1:500 – 1:2000<br/>IHC 1:50 – 1:100
|Molecular weight|| |
Phospho-DOK1-Y362 antibody was tube-contained.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Alternative antibody names|| |
|Database links|| |
Human UniProt/Swiss-Prot:<a href="http://www.uniprot.org/uniprot/Q99704">Q99704</a>
|Protein names|| |
|Protein function|| |
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3.
|Protein tissue specificity|| |
Expressed in pancreas, heart, leukocyte and spleen. Expressed in both resting and activated peripheral blood T-cells. Expressed in breast cancer.
|Protein sequence and domain|| |
Belongs to the DOK family. Type A subfamily.; Contains 1 IRS-type PTB domain.; Contains 1 PH domain. The PTB domain mediates receptor interaction.
|Protein post-translational modifications|| |
Constitutively tyrosine-phosphorylated. Phosphorylated by TEC (By similarity). Phosphorylated by LYN (By similarity). Phosphorylated on tyrosine residues by the insulin receptor kinase. Results in the negative regulation of the insulin signaling pathway. Phosphorylated on tyrosine residues by SRMS.
|Protein cellular localization|| |
Isoform 1: Cytoplasm. Nucleus.; Isoform 3: Cytoplasm, perinuclear region.
The protein encoded by this gene is part of a signal transduction pathway downstream of receptor tyrosine kinases. The encoded protein is a scaffold protein that helps form a platform for the assembly of multiprotein signaling complexes. Two transcript variants encoding different isoforms have been found for this gene.
|Research area|| |
<a href="http://antibodyplus.com/research-areas/">All research areas</a>><a href="http://antibodyplus.com/Signaling-Intermediates/">Signaling Intermediates</a>><a href="http://antibodyplus.com/product-tag/Dok/">Dok</a><br><a href="http://antibodyplus.com/product-tag/Signaling-Intermediates/"> (View all antibody categories related to Signaling Intermediates)</a>
AntibodyPlus can customize Phospho-DOK1-Y362 antibody according to your requirement, including bulk product size,etc. Please contact email@example.com. AntibodyPlus provides antibody trial sample for your own antibody validation.
|Product type|| |
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