Rabbit Polyclonal Phospho-DOK1-Y398 antibody (AP0249)

$99.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit Polyclonal Phospho-DOK1-Y398 antibody (AP0249)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000
IHC 1:50 – 1:100

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit Polyclonal Phospho-DOK1-Y398 antibody.

Alternative names:

Check alternative names for the antibody

Expand

P62DOK antibody;
Docking protein 1 62kD antibody|Docking protein 1 antibody|DOK 1 antibody|DOK1 antibody|DOK1_HUMAN antibody|Downstream of tyrosine kinase 1 antibody|p62(dok) antibody|P62DOK antibody|pp62 antibody|Anti-DOK1 antibody (ab8112)

SCBT cat No: sc-135888|sc-6929|sc-46093|sc-6277|sc-6934|sc-135889|

Name

Rabbit Polyclonal Phospho-DOK1-Y398 antibody

Catalogue No.

AP0249

Reactivity

Human, Mouse, Rat

Immunogen

A phospho specific peptide corresponding to residues surrounding Y398 of human DOK1

Host

Rabbit

Applications

WB, IHC

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

62kDa

Formulation

Phospho-DOK1-Y398 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

Affinity purification

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

P62DOK antibody;

Protein names

P62DOK;

Protein function

DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3.

Protein tissue specificity

Expressed in pancreas, heart, leukocyte and spleen. Expressed in both resting and activated peripheral blood T-cells. Expressed in breast cancer.

Protein sequence and domain

Belongs to the DOK family. Type A subfamily.; Contains 1 IRS-type PTB domain.; Contains 1 PH domain. The PTB domain mediates receptor interaction.

Protein post-translational modifications

Constitutively tyrosine-phosphorylated. Phosphorylated by TEC (By similarity). Phosphorylated by LYN (By similarity). Phosphorylated on tyrosine residues by the insulin receptor kinase. Results in the negative regulation of the insulin signaling pathway. Phosphorylated on tyrosine residues by SRMS.

Protein cellular localization

Isoform 1: Cytoplasm. Nucleus.; Isoform 3: Cytoplasm, perinuclear region.

Background

The protein encoded by this gene is part of a signal transduction pathway downstream of receptor tyrosine kinases. The encoded protein is a scaffold protein that helps form a platform for the assembly of multiprotein signaling complexes. Two transcript variants encoding different isoforms have been found for this gene.

Research area

<a href="http://antibodyplus.com/research-areas/">All research areas</a>><a href="http://antibodyplus.com/Signaling-Intermediates/">Signaling Intermediates</a>><a href="http://antibodyplus.com/product-tag/Dok/">Dok</a><br><a href="http://antibodyplus.com/product-tag/Signaling-Intermediates/"&gt; (View all antibody categories related to Signaling Intermediates)</a>

Note

AntibodyPlus can customize Phospho-DOK1-Y398 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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