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Rabbit Polyclonal Phospho-Eg5 (T926) antibody (STJ90532)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-1:2000; ELISA 1:5000;
Recommended protocols: check protocols
Click or hover above images to see image description for Eg5 (phospho Thr926) Polyclonal Antibody.
Check alternative names for the antibodyExpand
KIF11 antibody, EG5 antibody, KNSL1 antibody, TRIP5 antibody,|EG5 antibody|KNSL1 antibody|MCLMR antibody|Thyroid receptor-interacting protein 5 antibody|TR-interacting protein 5 antibody|TRIP-5 antibody|TRIP5 antibody|Anti-Eg5 antibody [mAbcam 51976] (ab51976)
SCBT cat No: sc-53691|sc-136223|sc-365681|sc-365593|sc-393311|
Eg5 (phospho Thr926) Polyclonal Antibody
|Catalogue No.|| |
Phospho-Eg5 (T926) Polyclonal Antibody detects endogenous levels of Eg5 protein only when phosphorylated at T926.
Synthesized phospho-peptide derived from Eg5 (phospho Thr926) at AA range 870-950
|Recommended dilution|| |
WB 1:500-1:2000; ELISA 1:5000;
|Molecular weight|| |
Eg5 (phospho Thr926) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Eg5 (phospho Thr926) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Kinesin-like protein KIF11 antibody, Kinesin-like protein 1 antibody, Kinesin-like spindle protein HKSP antibody, Kinesin-related motor protein Eg5 antibody, Thyroid receptor-interacting protein 5 antibody, TR-interacting protein 5 antibody, TRIP-5 antibody
|Protein names|| |
Kinesin-like protein KIF11 , Kinesin-like protein 1 , Kinesin-like spindle protein HKSP , Kinesin-related motor protein Eg5 , Thyroid receptor-interacting protein 5 , TR-interacting protein 5 , TRIP-5
|Protein function|| |
Motor protein required for establishing a bipolar spindle during mitosis . Required in non-mitotic cells for transport of secretory proteins from the Golgi complex to the cell surface .
|Involvement in disease|| |
Microcephaly with or without chorioretinopathy, lymphedema, or mental retardation (MCLMR) [MIM:152950]: An autosomal dominant disorder that involves an overlapping but variable spectrum of central nervous system and ocular developmental anomalies. Microcephaly ranges from mild to severe and is often associated with mild to moderate developmental delay and a characteristic facial phenotype with upslanting palpebral fissures, broad nose with rounded tip, long philtrum with thin upper lip, prominent chin, and prominent ears. Chorioretinopathy is the most common eye abnormality, but retinal folds, microphthalmia, and myopic and hypermetropic astigmatism have also been reported, and some individuals have no overt ocular phenotype. Congenital lymphedema, when present, is typically confined to the dorsa of the feet, and lymphoscintigraphy reveals the absence of radioactive isotope uptake from the webspaces between the toes. . Note: The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. BimC subfamily. / Contains 1 kinesin motor domain.
|Protein post-translational modifications|| |
Phosphorylated exclusively on serine during S phase, but on both serine and Thr-926 during mitosis, so controlling the association of KIF11 with the spindle apparatus (probably during early prophase). / A subset of this protein primarily localized at the spindle pole is phosphorylated by NEK6 during mitosis; phosphorylation is required for mitotic function.
|Protein cellular localization|| |
Cytoplasm / Cytoplasm > cytoskeleton > spindle pole
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St John’s Laboratory Ltd.
|Product type|| |
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