Rabbit Polyclonal Phospho-EGFR (Y1092) antibody (STJ90248)


Reactivity: Human, Mouse, Rat
Applications: WB, IHC, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Rabbit Polyclonal Phospho-EGFR (Y1092) antibody (STJ90248)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, IHC, ELISA

Recommended dilution: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:20000;

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for EGFR (phospho Tyr1092) Polyclonal Antibody.

Alternative names:

Check alternative names for the antibody


EGFR antibody, ERBB antibody, ERBB1 antibody, HER1 antibody,|Avian erythroblastic leukemia viral (v erb b) oncogene homolog antibody|Cell growth inhibiting protein 40 antibody|Cell proliferation inducing protein 61 antibody|EGF R antibody|EGFR antibody|EGFR_HUMAN antibody|Epidermal growth factor receptor (avian erythroblastic leukemia viral (v erb b) oncogene homolog) antibody|Epidermal growth factor receptor (erythroblastic leukemia viral (v erb b) oncogene homolog avian) antibody|Epidermal growth factor receptor antibody|erb-b2 receptor tyrosine kinase 1 antibody|ERBB antibody|ERBB1 antibody|Errp antibody|HER1 antibody|mENA antibody|NISBD2 antibody|Oncogen ERBB antibody|PIG61 antibody|Proto-oncogene c-ErbB-1 antibody|Receptor tyrosine protein kinase ErbB 1 antibody|Receptor tyrosine-protein kinase ErbB-1 antibody|SA7 antibody|Species antigen 7 antibody|Urogastrone antibody|v-erb-b Avian erythroblastic leukemia viral oncogen homolog antibody|wa2 antibody|Wa5 antibody|Anti-EGFR antibody [EP38Y] (ab52894)
SCBT cat No: sc-373746|



EGFR (phospho Tyr1092) Polyclonal Antibody

Catalogue No.



Human, Mouse, Rat


Phospho-EGFR (Y1092) Polyclonal Antibody detects endogenous levels of EGFR protein only when phosphorylated at Y1092.


Synthesized phospho-peptide derived from EGFR (phospho Tyr1092) at AA range 1030-1110





Recommended dilution

WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:20000;







Molecular weight

140-160 kDa


EGFR (phospho Tyr1092) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.


1 mg/ml


EGFR (phospho Tyr1092) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.


-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Epidermal growth factor receptor antibody, Proto-oncogene c-ErbB-1 antibody, Receptor tyrosine-protein kinase erbB-1 antibody

Database links

Human UniProt/Swiss-Prot:P00533;Mouse UniPort/Swiss-Prot: Q01279;Rat UniProt/Swiss-Port: Q9QX70;Human Entrez Gene: 1956;Mouse Entrez Gene: 13649;Rat Entrez Gene: Rn.37227

Protein names

Epidermal growth factor receptor , Proto-oncogene c-ErbB-1 , Receptor tyrosine-protein kinase erbB-1

Protein function

Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin. / Isoform 2 may act as an antagonist of EGF action. / ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. / Endocytosis and inhibition of the activated EGFR by phosphatases like PTPRJ and PTPRK constitute immediate regulatory mechanisms. Upon EGF-binding phosphorylates EPS15 that regulates EGFR endocytosis and activity. Moreover, inducible feedback inhibitors including LRIG1, SOCS4, SOCS5 and ERRFI1 constitute alternative regulatory mechanisms for the EGFR signaling.

Protein tissue specificity

Ubiquitously expressed. Isoform 2 is also expressed in ovarian cancers.

Involvement in disease

Lung cancer (LNCR) [MIM:211980]: A common malignancy affecting tissues of the lung. The most common form of lung cancer is non-small cell lung cancer (NSCLC) that can be divided into 3 major histologic subtypes: squamous cell carcinoma, adenocarcinoma, and large cell lung cancer. NSCLC is often diagnosed at an advanced stage and has a poor prognosis. . Note: The gene represented in this entry is involved in disease pathogenesis.; Inflammatory skin and bowel disease, neonatal, 2 (NISBD2) [MIM:616069]: A disorder characterized by inflammatory features with neonatal onset, involving the skin, hair, and gut. The skin lesions involve perioral and perianal erythema, psoriasiform erythroderma, with flares of erythema, scaling, and widespread pustules. Gastrointestinal symptoms include malabsorptive diarrhea that is exacerbated by intercurrent gastrointestinal infections. The hair is short or broken, and the eyelashes and eyebrows are wiry and disorganized. . Note: The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily. / Contains 1 protein kinase domain.

Protein post-translational modifications

Phosphorylation at Ser-695 is partial and occurs only if Thr-693 is phosphorylated. Phosphorylation at Thr-678 and Thr-693 by PRKD1 inhibits EGF-induced MAPK8/JNK1 activation. Dephosphorylation by PTPRJ prevents endocytosis and stabilizes the receptor at the plasma membrane. Autophosphorylation at Tyr-1197 is stimulated by methylation at Arg-1199 and enhances interaction with PTPN6. Autophosphorylation at Tyr-1092 and/or Tyr-1110 recruits STAT3. Dephosphorylated by PTPN1 and PTPN2. / Monoubiquitinated and polyubiquitinated upon EGF stimulation; which does not affect tyrosine kinase activity or signaling capacity but may play a role in lysosomal targeting. Polyubiquitin linkage is mainly through ‘Lys-63’, but linkage through ‘Lys-48’, ‘Lys-11’ and ‘Lys-29’ also occurs. Deubiquitination by OTUD7B prevents degradation. Ubiquitinated by RNF115 and RNF126 (By similarity). / Methylated. Methylation at Arg-1199 by PRMT5 stimulates phosphorylation at Tyr-1197.

Protein cellular localization

Cell membrane; Single-pass type I membrane protein / Endoplasmic reticulum membrane; Single-pass type I membrane protein / Golgi apparatus membrane; Single-pass type I membrane protein / Nucleus membrane; Single-pass type I membrane protein / Endosome / Endosome membrane / Nucleus / Secreted

Research area

All research areas>Membrane Receptors>EGFR
(View all antibody categories related to Membrane Receptors)


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St John’s Laboratory Ltd.

Product type

Primary antibody


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