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Rabbit Polyclonal Phospho-Elk-1 (S383) antibody (STJ90255)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IHC, IP, ELISA
Recommended dilution: WB 1:500-1:2000; IHC 1:100-1:300; IP 1:200-500; ELISA 1:20000;
Recommended protocols: check protocols
Click or hover above images to see image description for Elk-1 (phospho Ser383) Polyclonal Antibody.
Check alternative names for the antibodyExpand
ELK1 antibody,|ELK 1 antibody|Elk1 antibody|ELK1 member of ETS oncogene family antibody|ELK1 protein antibody|ELK1_HUMAN antibody|ELK2 member of ETS oncogene family antibody|ETS domain containing protein Elk 1 antibody|ETS domain containing protein Elk1 antibody|ETS domain protein Elk1 antibody|ETS domain-containing protein Elk-1 antibody|ETS like gene 1 antibody|Member of ETS oncogene family antibody|Oncogene Elk1 antibody|Tyrosine kinase (ELK1) oncogene antibody|Anti-ELK1 antibody [E277] – ChIP Grade (ab32106)
SCBT cat No: sc-65986|sc-365876|sc-22804|sc-355|sc-365715|sc-515041|sc-81264|sc-398959|
Elk-1 (phospho Ser383) Polyclonal Antibody
|Catalogue No.|| |
Human, Mouse, Rat
Phospho-Elk-1 (S383) Polyclonal Antibody detects endogenous levels of Elk-1 protein only when phosphorylated at S383.
Synthesized phospho-peptide derived from Elk-1 (phospho Ser383) at AA range 320-400
WB, IHC, IP, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IHC 1:100-1:300; IP 1:200-500; ELISA 1:20000;
|Molecular weight|| |
Elk-1 (phospho Ser383) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Elk-1 (phospho Ser383) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
ETS domain-containing protein Elk-1 antibody
|Protein names|| |
ETS domain-containing protein Elk-1
|Protein function|| |
Transcription factor that binds to purine-rich DNA sequences. Forms a ternary complex with SRF and the ETS and SRF motifs of the serum response element (SRE) on the promoter region of immediate early genes such as FOS and IER2. Induces target gene transcription upon JNK-signaling pathway stimulation (By similarity).
|Protein tissue specificity|| |
Lung and testis.
|Protein sequence and domain|| |
Belongs to the ETS family. / Contains 1 ETS DNA-binding domain.
|Protein post-translational modifications|| |
Sumoylation represses transcriptional activator activity as it results in recruitment of HDAC2 to target gene promoters which leads to decreased histone acetylation and reduced transactivator activity. It also regulates nuclear retention. / On mitogenic stimulation, phosphorylated on C-terminal serine and threonine residues by MAPK1. Ser-383 and Ser-389 are the preferred sites for MAPK1. In vitro, phosphorylation by MAPK1 potentiates ternary complex formation with the serum responses factors, SRE and SRF. Also phosphorylated on Ser-383 by MAPK8 and/or MAKP9. Phosphorylation leads to loss of sumoylation and restores transcriptional activator activity. Phosphorylated and activated by CAMK4, MAPK11, MAPK12 and MAPK14. Upon bFGF stimulus, phosphorylated by PAK1 (By similarity).
|Protein cellular localization|| |
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St John’s Laboratory Ltd.
|Product type|| |
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