Rabbit Polyclonal Phospho-Elk-1 (S389) antibody (STJ90256)

$99.00$319.00

Reactivity: Human, Mouse, Rat
Applications: WB, IHC, IP, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Rabbit Polyclonal Phospho-Elk-1 (S389) antibody (STJ90256)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, IHC, IP, ELISA

Recommended dilution: WB 1:500-1:2000; IHC 1:100-1:300; IP 1:200-500; ELISA 1:10000;

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Elk-1 (phospho Ser389) Polyclonal Antibody.

Alternative names:

Check alternative names for the antibody

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ELK1 antibody,|ELK 1 antibody|Elk1 antibody|ELK1 member of ETS oncogene family antibody|ELK1 protein antibody|ELK1_HUMAN antibody|ELK2 member of ETS oncogene family antibody|ETS domain containing protein Elk 1 antibody|ETS domain containing protein Elk1 antibody|ETS domain protein Elk1 antibody|ETS domain-containing protein Elk-1 antibody|ETS like gene 1 antibody|Member of ETS oncogene family antibody|Oncogene Elk1 antibody|Tyrosine kinase (ELK1) oncogene antibody|Anti-ELK1 antibody [E277] – ChIP Grade (ab32106)
SCBT cat No: sc-65986|sc-365876|sc-22804|sc-355|sc-365715|sc-515041|sc-81264|sc-398959|

 

Name

Elk-1 (phospho Ser389) Polyclonal Antibody

Catalogue No.

STJ90256

Reactivity

Human, Mouse, Rat

Specificity

Phospho-Elk-1 (S389) Polyclonal Antibody detects endogenous levels of Elk-1 protein only when phosphorylated at S389.

Immunogen

Synthesized phospho-peptide derived from Elk-1 (phospho Ser389) at AA range 330-410

Host

Rabbit

Applications

WB, IHC, IP, ELISA

Recommended dilution

WB 1:500-1:2000; IHC 1:100-1:300; IP 1:200-500; ELISA 1:10000;

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

48 kDa

Formulation

Elk-1 (phospho Ser389) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

Elk-1 (phospho Ser389) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

ETS domain-containing protein Elk-1 antibody

Database links

Human UniProt/Swiss-Prot:P19419;Mouse UniPort/Swiss-Prot: P41969;Rat UniProt/Swiss-Port: A4GTP4;Human Entrez Gene: 2002;Mouse Entrez Gene: 13712;Rat Entrez Gene: Rn.203416

Protein names

ETS domain-containing protein Elk-1

Protein function

Transcription factor that binds to purine-rich DNA sequences. Forms a ternary complex with SRF and the ETS and SRF motifs of the serum response element (SRE) on the promoter region of immediate early genes such as FOS and IER2. Induces target gene transcription upon JNK-signaling pathway stimulation (By similarity).

Protein tissue specificity

Lung and testis.

Protein sequence and domain

Belongs to the ETS family. / Contains 1 ETS DNA-binding domain.

Protein post-translational modifications

Sumoylation represses transcriptional activator activity as it results in recruitment of HDAC2 to target gene promoters which leads to decreased histone acetylation and reduced transactivator activity. It also regulates nuclear retention. / On mitogenic stimulation, phosphorylated on C-terminal serine and threonine residues by MAPK1. Ser-383 and Ser-389 are the preferred sites for MAPK1. In vitro, phosphorylation by MAPK1 potentiates ternary complex formation with the serum responses factors, SRE and SRF. Also phosphorylated on Ser-383 by MAPK8 and/or MAKP9. Phosphorylation leads to loss of sumoylation and restores transcriptional activator activity. Phosphorylated and activated by CAMK4, MAPK11, MAPK12 and MAPK14. Upon bFGF stimulus, phosphorylated by PAK1 (By similarity).

Protein cellular localization

Nucleus

Research area

All research areas>Transcription Regulators>Elk
(View all antibody categories related to Transcription Regulators)

Note

AntibodyPlus can customize Elk-1 (phospho Ser389) Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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