Rabbit Polyclonal Phospho-ELK1-T417 antibody (AP0346)

$99.00$259.00

Reactivity: Human,Mouse,Rat
Applications: IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit Polyclonal Phospho-ELK1-T417 antibody (AP0346)

Supplier: ABclonal Inc.

Recommended applications: IHC,IF

Recommended dilution:

IHC 1:50 – 1:100
IF 1:100 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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ELK 1 antibody|Elk1 antibody|ELK1 member of ETS oncogene family antibody|ELK1 protein antibody|ELK1_HUMAN antibody|ELK2 member of ETS oncogene family antibody|ETS domain containing protein Elk 1 antibody|ETS domain containing protein Elk1 antibody|ETS domain protein Elk1 antibody|ETS domain-containing protein Elk-1 antibody|ETS like gene 1 antibody|Member of ETS oncogene family antibody|Oncogene Elk1 antibody|Tyrosine kinase (ELK1) oncogene antibody|Anti-ELK1 antibody [E277] – ChIP Grade (ab32106)

SCBT cat No: sc-65986|sc-365876|sc-22804|sc-355|sc-365715|sc-515041|sc-81264|sc-398959|

Name

Rabbit Polyclonal Phospho-ELK1-T417 antibody

Catalogue No.

AP0346

Reactivity

Human, Mouse, Rat

Immunogen

A phospho specific peptide corresponding to residues surrounding T417 of human ELK1

Host

Rabbit

Applications

IHC, IF

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

47kDa

Formulation

Phospho-ELK1-T417 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

Affinity purification

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Protein function

Transcription factor that binds to purine-rich DNA sequences. Forms a ternary complex with SRF and the ETS and SRF motifs of the serum response element (SRE) on the promoter region of immediate early genes such as FOS and IER2. Induces target gene transcription upon JNK-signaling pathway stimulation (By similarity).

Protein tissue specificity

Lung and testis.

Protein sequence and domain

Belongs to the ETS family.; Contains 1 ETS DNA-binding domain.

Protein post-translational modifications

Sumoylation represses transcriptional activator activity as it results in recruitment of HDAC2 to target gene promoters which leads to decreased histone acetylation and reduced transactivator activity. It also regulates nuclear retention.; On mitogenic stimulation, phosphorylated on C-terminal serine and threonine residues by MAPK1. Ser-383 and Ser-389 are the preferred sites for MAPK1. In vitro, phosphorylation by MAPK1 potentiates ternary complex formation with the serum responses factors, SRE and SRF. Also phosphorylated on Ser-383 by MAPK8 and/or MAKP9. Phosphorylation leads to loss of sumoylation and restores transcriptional activator activity. Phosphorylated and activated by CAMK4, MAPK11, MAPK12 and MAPK14. Upon bFGF stimulus, phosphorylated by PAK1 (By similarity).

Protein cellular localization

Nucleus.

Background

This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum response element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is a nuclear target for the ras-raf-MAPK signaling cascade. This gene produces multiple isoforms by using alternative translational start codons and by alternative splicing. Related pseudogenes have been identified on chromosomes 7 and 14.

Research area

<a href="http://antibodyplus.com/research-areas/">All research areas</a>><a href="http://antibodyplus.com/Transcription-Regulators/">Transcription Regulators</a>><a href="http://antibodyplus.com/product-tag/Elf/">Elf</a><br><a href="http://antibodyplus.com/product-tag/Transcription-Regulators/"&gt; (View all antibody categories related to Transcription Regulators)</a>

Note

AntibodyPlus can customize Phospho-ELK1-T417 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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