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Rabbit Polyclonal Phospho-ELK1-T417 antibody (AP0346)
Supplier: ABclonal Inc.
Recommended applications: IHC,IF
IHC 1:50 – 1:100
IF 1:100 – 1:200
Recommended protocols: check protocols
Click or hover above images to see image description for Rabbit Polyclonal Phospho-ELK1-T417 antibody.
Check alternative names for the antibodyExpand
ELK 1 antibody|Elk1 antibody|ELK1 member of ETS oncogene family antibody|ELK1 protein antibody|ELK1_HUMAN antibody|ELK2 member of ETS oncogene family antibody|ETS domain containing protein Elk 1 antibody|ETS domain containing protein Elk1 antibody|ETS domain protein Elk1 antibody|ETS domain-containing protein Elk-1 antibody|ETS like gene 1 antibody|Member of ETS oncogene family antibody|Oncogene Elk1 antibody|Tyrosine kinase (ELK1) oncogene antibody|Anti-ELK1 antibody [E277] – ChIP Grade (ab32106)
SCBT cat No: sc-65986|sc-365876|sc-22804|sc-355|sc-365715|sc-515041|sc-81264|sc-398959|
Rabbit Polyclonal Phospho-ELK1-T417 antibody
|Catalogue No.|| |
Human, Mouse, Rat
A phospho specific peptide corresponding to residues surrounding T417 of human ELK1
|Recommended dilution|| |
IHC 1:50 – 1:100<br/>IF 1:100 – 1:200
|Molecular weight|| |
Phospho-ELK1-T417 antibody was tube-contained.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Database links|| |
Human UniProt/Swiss-Prot:<a href="http://www.uniprot.org/uniprot/P19419">P19419</a>
|Protein function|| |
Transcription factor that binds to purine-rich DNA sequences. Forms a ternary complex with SRF and the ETS and SRF motifs of the serum response element (SRE) on the promoter region of immediate early genes such as FOS and IER2. Induces target gene transcription upon JNK-signaling pathway stimulation (By similarity).
|Protein tissue specificity|| |
Lung and testis.
|Protein sequence and domain|| |
Belongs to the ETS family.; Contains 1 ETS DNA-binding domain.
|Protein post-translational modifications|| |
Sumoylation represses transcriptional activator activity as it results in recruitment of HDAC2 to target gene promoters which leads to decreased histone acetylation and reduced transactivator activity. It also regulates nuclear retention.; On mitogenic stimulation, phosphorylated on C-terminal serine and threonine residues by MAPK1. Ser-383 and Ser-389 are the preferred sites for MAPK1. In vitro, phosphorylation by MAPK1 potentiates ternary complex formation with the serum responses factors, SRE and SRF. Also phosphorylated on Ser-383 by MAPK8 and/or MAKP9. Phosphorylation leads to loss of sumoylation and restores transcriptional activator activity. Phosphorylated and activated by CAMK4, MAPK11, MAPK12 and MAPK14. Upon bFGF stimulus, phosphorylated by PAK1 (By similarity).
|Protein cellular localization|| |
This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum response element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is a nuclear target for the ras-raf-MAPK signaling cascade. This gene produces multiple isoforms by using alternative translational start codons and by alternative splicing. Related pseudogenes have been identified on chromosomes 7 and 14.
|Research area|| |
<a href="http://antibodyplus.com/research-areas/">All research areas</a>><a href="http://antibodyplus.com/Transcription-Regulators/">Transcription Regulators</a>><a href="http://antibodyplus.com/product-tag/Elf/">Elf</a><br><a href="http://antibodyplus.com/product-tag/Transcription-Regulators/"> (View all antibody categories related to Transcription Regulators)</a>
AntibodyPlus can customize Phospho-ELK1-T417 antibody according to your requirement, including bulk product size,etc. Please contact firstname.lastname@example.org. AntibodyPlus provides antibody trial sample for your own antibody validation.
|Product type|| |
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