No products in the cart.
Rabbit Polyclonal Phospho-EphA4 (Y596) antibody (STJ90667)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-1:2000; ELISA 1:10000;
Recommended protocols: check protocols
Click or hover above images to see image description for EphA4 (phospho Tyr596) Polyclonal Antibody.
Check alternative names for the antibodyExpand
EPHA4 antibody, HEK8 antibody, SEK antibody, TYRO1 antibody,|Cek 8 antibody|CEK8 antibody|EK8 antibody|eph receptor a4 antibody|EPH-like kinase 8 antibody|EPHA4 antibody|EPHA4_HUMAN antibody|Ephrin type-A receptor 4 antibody|HEK 8 antibody|hEK8 antibody|Receptor protein-tyrosine kinase HEK8 antibody|Sek 1 antibody|SEK antibody|TYRO 1 protein tyrosine kinase antibody|TYRO1 antibody|Tyrosine-protein kinase receptor SEK antibody|Tyrosine-protein kinase TYRO1 antibody|Anti-Eph receptor A4 antibody (ab5389)
SCBT cat No: sc-135897|sc-922|sc-25457|sc-921|
EphA4 (phospho Tyr596) Polyclonal Antibody
|Catalogue No.|| |
Phospho-EphA4 (Y596) Polyclonal Antibody detects endogenous levels of EphA4 protein only when phosphorylated at Y596.
Synthesized phospho-peptide derived from EphA4 (phospho Tyr596) at AA range 540-620
|Recommended dilution|| |
WB 1:500-1:2000; ELISA 1:10000;
|Molecular weight|| |
EphA4 (phospho Tyr596) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
EphA4 (phospho Tyr596) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Ephrin type-A receptor 4 antibody, EPH-like kinase 8 antibody, EK8 antibody, hEK8 antibody, Tyrosine-protein kinase TYRO1 antibody, Tyrosine-protein kinase receptor SEK antibody
|Protein names|| |
Ephrin type-A receptor 4 , EPH-like kinase 8 , EK8 , hEK8 , Tyrosine-protein kinase TYRO1 , Tyrosine-protein kinase receptor SEK
|Protein function|| |
Receptor tyrosine kinase which binds membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous, it has the unique property among Eph receptors to bind and to be physiologically activated by both GPI-anchored ephrin-A and transmembrane ephrin-B ligands including EFNA1 and EFNB3. Upon activation by ephrin ligands, modulates cell morphology and integrin-dependent cell adhesion through regulation of the Rac, Rap and Rho GTPases activity. Plays an important role in the development of the nervous system controlling different steps of axonal guidance including the establishment of the corticospinal projections. May also control the segregation of motor and sensory axons during neuromuscular circuit development. In addition to its role in axonal guidance plays a role in synaptic plasticity. Activated by EFNA1 phosphorylates CDK5 at ‘Tyr-15’ which in turn phosphorylates NGEF regulating RHOA and dendritic spine morphogenesis. In the nervous system, plays also a role in repair after injury preventing axonal regeneration and in angiogenesis playing a role in central nervous system vascular formation. Additionally, its promiscuity makes it available to participate in a variety of cell-cell signaling regulating for instance the development of the thymic epithelium. / ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
|Protein tissue specificity|| |
|Protein sequence and domain|| |
The protein kinase domain mediates interaction with NGEF. / Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. / Contains 1 Eph LBD (Eph ligand-binding) domain. / Contains 2 fibronectin type-III domains. / Contains 1 protein kinase domain. / Contains 1 SAM (sterile alpha motif) domain.
|Protein cellular localization|| |
Cell membrane / Cell projection > axon / Cell projection > dendrite / Cell junction > synapse > postsynaptic cell membrane > postsynaptic density / Early endosome
AntibodyPlus can customize EphA4 (phospho Tyr596) Antibody according to your requirement, including bulk product size,etc. Please contact firstname.lastname@example.org. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.
St John’s Laboratory Ltd.
|Product type|| |
There are no reviews for this product yet.
By submitting a review, get following benefits:
1. Receive $50 ABcoins as credit for each review.
2. First trial sample order will be fully refunded as credit.
3. Have a chance to win a $50 amazon gift card!
There is no extra validation for this product yet.
Check other extra validated antibodies below: