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Rabbit Polyclonal Phospho-EpoR (Y368) antibody (STJ90712)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IF, ELISA
Recommended dilution: WB 1:500-1:2000; IF 1:200-1:1000; ELISA 1:10000;
Recommended protocols: check protocols
Click or hover above images to see image description for EpoR (phospho Tyr368) Polyclonal Antibody.
Check alternative names for the antibodyExpand
EPOR antibody,|EPO R antibody|EPO-R antibody|epor antibody|EPOR_HUMAN antibody|Erythropoietin receptor antibody|Erythropoietin receptor precursor antibody|MGC138358 antibody|Anti-EPO Receptor antibody [MM-0031-6G7] (ab56310)
SCBT cat No: sc-695|sc-365662|sc-82590|sc-5624|sc-697|sc-82593|sc-33817|
EpoR (phospho Tyr368) Polyclonal Antibody
|Catalogue No.|| |
Human, Mouse, Rat
Phospho-EpoR (Y368) Polyclonal Antibody detects endogenous levels of EpoR protein only when phosphorylated at Y368.
Synthesized phospho-peptide derived from EpoR (phospho Tyr368) at AA range 310-390
WB, IF, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IF 1:200-1:1000; ELISA 1:10000;
|Molecular weight|| |
EpoR (phospho Tyr368) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
EpoR (phospho Tyr368) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Erythropoietin receptor antibody, EPO-R antibody
|Protein names|| |
Erythropoietin receptor , EPO-R
|Protein function|| |
Receptor for erythropoietin. Mediates erythropoietin-induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also activate STAT1 and STAT3. May also activate the LYN tyrosine kinase. / Isoform EPOR-T acts as a dominant-negative receptor of EPOR-mediated signaling.
|Protein tissue specificity|| |
Erythroid cells and erythroid progenitor cells. Isoform EPOR-F is the most abundant form in EPO-dependent erythroleukemia cells and in late-stage erythroid progenitors. Isoform EPOR-S and isoform EPOR-T are the predominant forms in bone marrow. Isoform EPOR-T is the most abundant from in early-stage erythroid progenitor cells.
|Involvement in disease|| |
Erythrocytosis, familial, 1 (ECYT1) [MIM:133100]: An autosomal dominant disorder characterized by increased serum red blood cell mass, elevated hemoglobin and hematocrit, hypersensitivity of erythroid progenitors to erythropoietin, erythropoietin low serum levels, and no increase in platelets nor leukocytes. It has a relatively benign course and does not progress to leukemia. . Note: The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding. / The box 1 motif is required for JAK interaction and/or activation. / Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases. / Belongs to the type I cytokine receptor family. Type 1 subfamily. / Contains 1 fibronectin type-III domain.
|Protein post-translational modifications|| |
On EPO stimulation, phosphorylated on C-terminal tyrosine residues by JAK2. The phosphotyrosine motifs are also recruitment sites for several SH2-containing proteins and adapter proteins which mediate cell proliferation. Phosphorylation on Tyr-454 is required for PTPN6 interaction, Tyr-426 for PTPN11. Tyr-426 is also required for SOCS3 binding, but Tyr-454/Tyr-456 motif is the preferred binding site. / Ubiquitination at Lys-281 mediates receptor internalization, whereas ubiquitination at Lys-453 promotes trafficking of activated receptors to the lysosomes for degradation (By similarity). Ubiquitinated by NOSIP; appears to be either multi-monoubiquitinated or polyubiquitinated. Ubiquitination mediates proliferation and survival of EPO-dependent cells.
|Protein cellular localization|| |
Cell membrane; Single-pass type I membrane protein / Secreted
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St John’s Laboratory Ltd.
|Product type|| |
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