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Rabbit Polyclonal Phospho-Eps15 (Y849) antibody (STJ90629)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-1:2000; ELISA 1:10000;
Recommended protocols: check protocols
Click or hover above images to see image description for Eps15 (phospho Tyr849) Polyclonal Antibody.
Check alternative names for the antibodyExpand
EPS15 antibody, AF1P antibody,|AF 1P antibody|AF 1p protein antibody|AF1P antibody|ALL1 fused gene from chromosome 1 antibody|Epidermal growth factor receptor pathway substrate 15 antibody|Epidermal growth factor receptor substrate 15 antibody|EPS 15 antibody|MLLT 5 antibody|MLLT5 antibody|Protein Eps 15 antibody|Protein Eps15 antibody|Anti-EPS15 antibody [EP9280] (ab174291)
SCBT cat No: sc-135898|sc-534|sc-390259|sc-374578|sc-1840|sc-11716|
Eps15 (phospho Tyr849) Polyclonal Antibody
|Catalogue No.|| |
Human, Mouse, Rat
Phospho-Eps15 (Y849) Polyclonal Antibody detects endogenous levels of Eps15 protein only when phosphorylated at Y849.
Synthesized phospho-peptide derived from Eps15 (phospho Tyr849) at AA range 790-870
|Recommended dilution|| |
WB 1:500-1:2000; ELISA 1:10000;
|Molecular weight|| |
Eps15 (phospho Tyr849) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Eps15 (phospho Tyr849) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Epidermal growth factor receptor substrate 15 antibody, Protein Eps15 antibody, Protein AF-1p antibody
|Protein names|| |
Epidermal growth factor receptor substrate 15 , Protein Eps15 , Protein AF-1p
|Protein function|| |
Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2.
|Protein tissue specificity|| |
|Involvement in disease|| |
Note: A chromosomal aberration involving EPS15 is found in acute leukemias. Translocation t(1;11)(p32;q23) with KMT2A/MLL1. The result is a rogue activator protein.
|Protein sequence and domain|| |
The EH domain interacts with Asn-Pro-Phe (NPF) motifs of target proteins. / The UIM (ubiquitin-interacting motif) repeats specifically bind ‘Lys-33’-linked ubiquitin. / Contains 2 EF-hand domains. / Contains 3 EH domains. / Contains 2 UIM (ubiquitin-interacting motif) domains.
|Protein post-translational modifications|| |
Phosphorylation on Tyr-849 is involved in the internalization of EGFR. Not required for membrane translocation after EGF treatment or for targeting to coated pits, but essential for a subsequent step in EGFR endocytosis (By similarity). Phosphorylated on serine upon DNA damage, probably by ATM or ATR. / Ubiquitinated.
|Protein cellular localization|| |
Cytoplasm / Cell membrane; Peripheral membrane protein; Cytoplasmic side / Membrane > clathrin-coated pit / Early endosome membrane / Peripheral membrane protein / Cytoplasmic side
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St John’s Laboratory Ltd.
|Product type|| |
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