Rabbit Polyclonal Phospho-ERBB2-Y1221/Y1222 antibody (AP0149)

$99.00$259.00

Reactivity: Human
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit Polyclonal Phospho-ERBB2-Y1221/Y1222 antibody (AP0149)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:500 – 1:2000

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit Polyclonal Phospho-ERBB2-Y1221/Y1222 antibody.

Alternative names:

Check alternative names for the antibody

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NEU antibody; NGL antibody; HER2 antibody; TKR1 antibody; CD340 antibody; HER-2 antibody; MLN 19 antibody; HER-2/neu antibody;
Verb b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog antibody|C erb B2/neu protein antibody|CD340 antibody|CD340 antigen antibody|Cerb B2/neu protein antibody|CerbB2 antibody|Erb b2 receptor tyrosine kinase 2 antibody|ERBB2 antibody|ERBB2_HUMAN antibody|HER 2 antibody|HER 2/NEU antibody|HER2 antibody|Herstatin antibody|Human epidermal growth factor receptor 2 antibody|Metastatic lymph node gene 19 protein antibody|MLN 19 antibody|MLN19 antibody|NEU antibody|NEU proto oncogene antibody|Neuro/glioblastoma derived oncogene homolog antibody|Neuroblastoma/glioblastoma derived oncogene homolog antibody|NGL antibody|p185erbB2 antibody|Proto-oncogene c-ErbB-2 antibody|Proto-oncogene Neu antibody|Receptor tyrosine-protein kinase erbB-2 antibody|TKR1 antibody|Tyrosine kinase type cell surface receptor HER2 antibody|Tyrosine kinase-type cell surface receptor HER2 antibody|V erb b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog) antibody|V erb b2 avian erythroblastic leukemia viral oncogene homolog 2 antibody|V erb b2 avian erythroblastic leukemia viral oncoprotein 2 antibody|V erb b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) antibody|V erb b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog antibody|Verb b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) antibody|Anti-ErbB 2 antibody [3B5] (ab16901)

SCBT cat No: sc-71667|sc-23864|sc-33684|sc-136294|sc-08|sc-393712|sc-374382|sc-31154|sc-284|sc-377344|sc-52349|sc-31153|sc-7301|sc-134481|sc-166824|sc-32936|sc-25905|sc-25906|sc-100570|sc-366571|sc-161126|sc-161127|sc-136327|sc-377407|

Name

Rabbit Polyclonal Phospho-ERBB2-Y1221/Y1222 antibody

Catalogue No.

AP0149

Reactivity

Human

Immunogen

A phospho specific peptide corresponding to residues surrounding Y1221/Y1222 of human ERBB2

Host

Rabbit

Applications

WB

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

185kDa

Formulation

Phospho-ERBB2-Y1221/Y1222 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

Affinity purification

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

NEU antibody; NGL antibody; HER2 antibody; TKR1 antibody; CD340 antibody; HER-2 antibody; MLN 19 antibody; HER-2/neu antibody;

Protein names

NEU; NGL; HER2; TKR1; CD340; HER-2; MLN 19; HER-2/neu;

Protein function

Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization.; In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth.

Protein tissue specificity

Expressed in a variety of tumor tissues including primary breast tumors and tumors from small bowel, esophagus, kidney and mouth.

Protein sequence and domain

Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.; Contains 1 protein kinase domain.

Protein post-translational modifications

Autophosphorylated. Autophosphorylation occurs in trans, i.e. one subunit of the dimeric receptor phosphorylates tyrosine residues on the other subunit (Probable). Ligand-binding increases phosphorylation on tyrosine residues (PubMed:27134172). Signaling via SEMA4C promotes phosphorylation at Tyr-1248 (PubMed:17554007). Dephosphorylated by PTPN12 (PubMed:27134172).

Protein cellular localization

Isoform 1: Cell membrane; Single-pass type I membrane protein. Cytoplasm, perinuclear region. Nucleus. Note=Translocation to the nucleus requires endocytosis, probably endosomal sorting and is mediated by importin beta-1/KPNB1.; Isoform 2: Cytoplasm. Nucleus.; Isoform 3: Cytoplasm. Nucleus.

Background

This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.

Research area

<a href="http://antibodyplus.com/research-areas/">All research areas</a>><a href="http://antibodyplus.com/Membrane-Receptors/">Membrane Receptors</a>><a href="http://antibodyplus.com/product-tag/Neu/">Neu</a><br><a href="http://antibodyplus.com/product-tag/Membrane-Receptors/"&gt; (View all antibody categories related to Membrane Receptors)</a>

Note

AntibodyPlus can customize Phospho-ERBB2-Y1221/Y1222 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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