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Rabbit Polyclonal Phospho-ERBB2-Y877 antibody (AP0148)
Supplier: ABclonal Inc.
Recommended applications: WB
WB 1:200 – 1:500
Recommended protocols: check protocols
Click or hover above images to see image description for Rabbit Polyclonal Phospho-ERBB2-Y877 antibody.
Check alternative names for the antibodyExpand
C-erbB-2 antibody; ErbB2 antibody; antibody;
Verb b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog antibody|C erb B2/neu protein antibody|CD340 antibody|CD340 antigen antibody|Cerb B2/neu protein antibody|CerbB2 antibody|Erb b2 receptor tyrosine kinase 2 antibody|ERBB2 antibody|ERBB2_HUMAN antibody|HER 2 antibody|HER 2/NEU antibody|HER2 antibody|Herstatin antibody|Human epidermal growth factor receptor 2 antibody|Metastatic lymph node gene 19 protein antibody|MLN 19 antibody|MLN19 antibody|NEU antibody|NEU proto oncogene antibody|Neuro/glioblastoma derived oncogene homolog antibody|Neuroblastoma/glioblastoma derived oncogene homolog antibody|NGL antibody|p185erbB2 antibody|Proto-oncogene c-ErbB-2 antibody|Proto-oncogene Neu antibody|Receptor tyrosine-protein kinase erbB-2 antibody|TKR1 antibody|Tyrosine kinase type cell surface receptor HER2 antibody|Tyrosine kinase-type cell surface receptor HER2 antibody|V erb b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog) antibody|V erb b2 avian erythroblastic leukemia viral oncogene homolog 2 antibody|V erb b2 avian erythroblastic leukemia viral oncoprotein 2 antibody|V erb b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) antibody|V erb b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog antibody|Verb b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) antibody|Anti-ErbB 2 antibody [3B5] (ab16901)
SCBT cat No: sc-71667|sc-23864|sc-33684|sc-136294|sc-08|sc-393712|sc-374382|sc-31154|sc-284|sc-377344|sc-52349|sc-31153|sc-7301|sc-134481|sc-166824|sc-32936|sc-25905|sc-25906|sc-100570|sc-366571|sc-161126|sc-161127|sc-136327|sc-377407|
Rabbit Polyclonal Phospho-ERBB2-Y877 antibody
|Catalogue No.|| |
A phospho specific peptide corresponding to residues surrounding Y877 of human ERBB2
|Recommended dilution|| |
WB 1:200 – 1:500
|Molecular weight|| |
Phospho-ERBB2-Y877 antibody was tube-contained.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Alternative antibody names|| |
C-erbB-2 antibody; ErbB2 antibody; antibody;
|Database links|| |
Human UniProt/Swiss-Prot:<a href="http://www.uniprot.org/uniprot/P04626">P04626</a>
|Protein names|| |
|Protein function|| |
Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization.; In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth.
|Protein tissue specificity|| |
Expressed in a variety of tumor tissues including primary breast tumors and tumors from small bowel, esophagus, kidney and mouth.
|Protein sequence and domain|| |
Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.; Contains 1 protein kinase domain.
|Protein post-translational modifications|| |
Autophosphorylated. Autophosphorylation occurs in trans, i.e. one subunit of the dimeric receptor phosphorylates tyrosine residues on the other subunit (Probable). Ligand-binding increases phosphorylation on tyrosine residues (PubMed:27134172). Signaling via SEMA4C promotes phosphorylation at Tyr-1248 (PubMed:17554007). Dephosphorylated by PTPN12 (PubMed:27134172).
|Protein cellular localization|| |
Isoform 1: Cell membrane; Single-pass type I membrane protein. Cytoplasm, perinuclear region. Nucleus. Note=Translocation to the nucleus requires endocytosis, probably endosomal sorting and is mediated by importin beta-1/KPNB1.; Isoform 2: Cytoplasm. Nucleus.; Isoform 3: Cytoplasm. Nucleus.
Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Not activated by EGF, TGF-a and amphiregulin.
|Research area|| |
<a href="http://antibodyplus.com/research-areas/">All research areas</a>><a href="http://antibodyplus.com/Membrane-Receptors/">Membrane Receptors</a>><a href="http://antibodyplus.com/product-tag/Neu/">Neu</a><br><a href="http://antibodyplus.com/product-tag/Membrane-Receptors/"> (View all antibody categories related to Membrane Receptors)</a>
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|Product type|| |
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