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Rabbit Polyclonal Phospho-ERK 3 (S189) antibody (STJ90898)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IHC, ELISA
Recommended dilution: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:5000;
Recommended protocols: check protocols
Click or hover above images to see image description for ERK 3 (phospho Ser189) Polyclonal Antibody.
Check alternative names for the antibodyExpand
MAPK6 antibody, ERK3 antibody, PRKM6 antibody,|ERK-3 antibody|ERK3 antibody|Extracellular signal regulated kinase 3 antibody|Extracellular signal regulated kinase p97 antibody|Extracellular signal-regulated kinase 3 antibody|HsT17250 antibody|MAP kinase 6 antibody|MAP kinase isoform p97 antibody|MAPK 6 antibody|MAPK6 antibody|Mitogen activated protein kinase 6 antibody|Mitogen-activated protein kinase 6 antibody|MK06_HUMAN antibody|p97 MAPK antibody|p97-MAPK antibody|PRKM6 antibody|Protein kinase mitogen activated 5 antibody|Protein kinase mitogen activated 6 antibody|Anti-MAPK6 antibody [EP1720Y] (ab53277)
SCBT cat No: sc-365234|sc-155|sc-374239|sc-393371|sc-156|
ERK 3 (phospho Ser189) Polyclonal Antibody
|Catalogue No.|| |
Human, Mouse, Rat
Phospho-ERK 3 (S189) Polyclonal Antibody detects endogenous levels of ERK 3 protein only when phosphorylated at S189.
Synthesized phospho-peptide derived from ERK 3 (phospho Ser189) at AA range 130-210
WB, IHC, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:5000;
|Molecular weight|| |
ERK 3 (phospho Ser189) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
ERK 3 (phospho Ser189) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Mitogen-activated protein kinase 6 antibody, MAP kinase 6 antibody, MAPK 6 antibody, Extracellular signal-regulated kinase 3 antibody, ERK-3 antibody, MAP kinase isoform p97 antibody, p97-MAPK antibody
|Protein names|| |
Mitogen-activated protein kinase 6 , MAP kinase 6 , MAPK 6 , Extracellular signal-regulated kinase 3 , ERK-3 , MAP kinase isoform p97 , p97-MAPK
|Protein function|| |
Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK3/MAPK6 is phosphorylated at Ser-189 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6. May promote entry in the cell cycle (By similarity). / ATP + a protein = ADP + a phosphoprotein. / Mg2+ / Activated by phosphorylation at Ser-189.
|Protein tissue specificity|| |
Highest expression in the skeletal muscle, followed by the brain. Also found in heart, placenta, lung, liver, pancreas, kidney and skin fibroblasts.
|Protein sequence and domain|| |
In contrast to classical MAPKs, the TXY motif within the activation loop is replaced by the SEG motif, whose phosphorylation activates the MAP kinases. / Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. / Contains 1 protein kinase domain.
|Protein post-translational modifications|| |
Phosphorylated at Ser-189 by PAK1, PAK2 and PAK3 resulting in catalytic activation. Phosphorylated by MAPKAPK5 at other sites. / Ubiquitination at Met-1 leads to degradation by the proteasome pathway.
|Protein cellular localization|| |
Cytoplasm / Nucleus
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St John’s Laboratory Ltd.
|Product type|| |
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