Rabbit Polyclonal Phospho-ERK1-T202/Y204 + ERK2-T185/Y187 antibody (AP0472)

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Reactivity: Human,Mouse,Rat
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit Polyclonal Phospho-ERK1-T202/Y204 + ERK2-T185/Y187 antibody (AP0472)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:500 – 1:2000

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit Polyclonal Phospho-ERK1-T202/Y204 + ERK2-T185/Y187 antibody.

Alternative names:

Check alternative names for the antibody

Expand

ERK antibody; p38 antibody; p40 antibody; p41 antibody; ERK2 antibody; ERT1 antibody; MAPK2 antibody; PRKM1 antibody; PRKM2 antibody; P42MAPK antibody; p41mapk antibody;
ERK 1 antibody|Extracellular signal-regulated kinase 2 antibody|HS44KDAP antibody|HUMKER1A antibody|Insulin stimulated MAP2 kinase antibody|MAP kinase 1 antibody|MAP kinase 2 antibody|MAP kinase 3 antibody|MAP kinase isoform p42 antibody|MAP kinase isoform p44 antibody|MAPK 1 antibody|MAPK 2 antibody|Mapk1 antibody|MAPK2 antibody|MAPK3 antibody|Microtubule associated protein 2 kinase antibody|Mitogen activated protein kinase 3 antibody|Mitogen-activated protein kinase 1 antibody|Mitogen-activated protein kinase 2 antibody|MK01_HUMAN antibody|p38 antibody|p40 antibody|p41 antibody|p41mapk antibody|p42-MAPK antibody|P42MAPK antibody|p44 ERK1 antibody|p44 MAPK antibody|P44ERK1 antibody|P44MAPK antibody|PRKM1 antibody|PRKM2 antibody|PRKM3 antibody|Protein tyrosine kinase ERK2 antibody|Anti-ERK1 + ERK2 antibody (ab17942)

SCBT cat No: sc-81457|sc-136288|sc-65981|sc-81458|sc-81459|sc-154|sc-271458|sc-1647|sc-271451|sc-153|sc-365234|sc-155|sc-374239|

Name

Rabbit Polyclonal Phospho-ERK1-T202/Y204 + ERK2-T185/Y187 antibody

Catalogue No.

AP0472

Reactivity

Human, Mouse, Rat

Immunogen

A phospho specific peptide corresponding to residues surrounding T202/Y204 of human Erk1/2

Host

Rabbit

Applications

WB

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

42,44KD

Formulation

Phospho-ERK1-T202/Y204 + ERK2-T185/Y187 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

Affinity purification

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

ERK antibody; p38 antibody; p40 antibody; p41 antibody; ERK2 antibody; ERT1 antibody; MAPK2 antibody; PRKM1 antibody; PRKM2 antibody; P42MAPK antibody; p41mapk antibody;

Protein names

ERK; p38; p40; p41; ERK2; ERT1; MAPK2; PRKM1; PRKM2; P42MAPK; p41mapk;

Protein function

Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis. Moreover, the MAPK/ERK cascade is also involved in the regulation of the endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC); as well as in the fragmentation of the Golgi apparatus during mitosis. The substrates include transcription factors (such as ATF2, BCL6, ELK1, ERF, FOS, HSF4 or SPZ1), cytoskeletal elements (such as CANX, CTTN, GJA1, MAP2, MAPT, PXN, SORBS3 or STMN1), regulators of apoptosis (such as BAD, BTG2, CASP9, DAPK1, IER3, MCL1 or PPARG), regulators of translation (such as EIF4EBP1) and a variety of other signaling-related molecules (like ARHGEF2, FRS2 or GRB10). Protein kinases (such as RAF1, RPS6KA1/RSK1, RPS6KA3/RSK2, RPS6KA2/RSK3, RPS6KA6/RSK4, SYK, MKNK1/MNK1, MKNK2/MNK2, RPS6KA5/MSK1, RPS6KA4/MSK2, MAPKAPK3 or MAPKAPK5) and phosphatases (such as DUSP1, DUSP4, DUSP6 or DUSP16) are other substrates which enable the propagation the MAPK/ERK signal to additional cytosolic and nuclear targets, thereby extending the specificity of the cascade.

Protein sequence and domain

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.; Contains 1 protein kinase domain. The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

Protein post-translational modifications

Phosphorylated upon KIT and FLT3 signaling (By similarity). Dually phosphorylated on Thr-202 and Tyr-204, which activates the enzyme. Ligand-activated ALK induces tyrosine phosphorylation. Dephosphorylated by PTPRJ at Tyr-204.

Protein cellular localization

Cytoplasm. Nucleus. Note=Autophosphorylation at Thr-207 promotes nuclear localization.

Background

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene.

Research area

<a href="http://antibodyplus.com/research-areas/">All research areas</a>><a href="http://antibodyplus.com/Kinases-and-Phosphatases/">Kinases and Phosphatases</a>><a href="http://antibodyplus.com/product-tag/Akt/">Akt</a><br><a href="http://antibodyplus.com/product-tag/Kinases-and-Phosphatases/"&gt; (View all antibody categories related to Kinases and Phosphatases)</a>

Note

AntibodyPlus can customize Phospho-ERK1-T202/Y204 + ERK2-T185/Y187 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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