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Rabbit Polyclonal Phospho-Ezrin (Y478) antibody (STJ90570)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IHC, ELISA
Recommended dilution: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:5000;
Recommended protocols: check protocols
Click or hover above images to see image description for Ezrin (phospho Tyr478) Polyclonal Antibody.
Check alternative names for the antibodyExpand
EZR antibody, VIL2 antibody,|Villin 2 ezrin antibody|CVIL antibody|CVL antibody|Cytovillin 2 antibody|Cytovillin antibody|DKFZp762H157 antibody|Epididymis secretory protein Li 105 antibody|EZR antibody|EZRI_HUMAN antibody|Ezrin antibody|FLJ26216 antibody|HEL S 105 antibody|MGC1584 antibody|p81 antibody|VIL 2 antibody|VIL2 antibody|Villin 2 (ezrin) antibody|Villin 2 antibody|Villin-2 antibody|Villin2 antibody|Anti-Ezrin antibody [3C12] (ab4069)
SCBT cat No: sc-58758|sc-32759|sc-71080|sc-71081|sc-71082|sc-271456|sc-6409|sc-6407|sc-271541|sc-398807|sc-377205|sc-20773|sc-32918|sc-398542|sc-56388|sc-71086|sc-71088|sc-71087|
Ezrin (phospho Tyr478) Polyclonal Antibody
|Catalogue No.|| |
Human, Mouse, Rat
Phospho-Ezrin (Y478) Polyclonal Antibody detects endogenous levels of Ezrin protein only when phosphorylated at Y478.
Synthesized phospho-peptide derived from Ezrin (phospho Tyr478) at AA range 420-500
WB, IHC, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:5000;
|Molecular weight|| |
Ezrin (phospho Tyr478) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Ezrin (phospho Tyr478) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Ezrin antibody, Cytovillin antibody, Villin-2 antibody, p81 antibody
|Protein names|| |
Ezrin , Cytovillin , Villin-2 , p81
|Protein function|| |
Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis. / A head-to-tail association, of the N-terminal and C-terminal halves results in a closed conformation (inactive form) which is incapable of actin or membrane-binding.
|Protein tissue specificity|| |
Expressed in cerebral cortex, basal ganglia, hippocampus, hypophysis, and optic nerve. Weakly expressed in brain stem and diencephalon. Stronger expression was detected in gray matter of frontal lobe compared to white matter (at protein level). Component of the microvilli of intestinal epithelial cells. Preferentially expressed in astrocytes of hippocampus, frontal cortex, thalamus, parahippocampal cortex, amygdala, insula, and corpus callosum. Not detected in neurons in most tissues studied.
|Protein sequence and domain|| |
The [IL]-x-C-x-x-[DE] motif is a proposed target motif for cysteine S-nitrosylation mediated by the iNOS-S100A8/A9 transnitrosylase complex. / Contains 1 FERM domain.
|Protein post-translational modifications|| |
Phosphorylated by tyrosine-protein kinases. Phosphorylation by ROCK2 suppresses the head-to-tail association of the N-terminal and C-terminal halves resulting in an opened conformation which is capable of actin and membrane-binding (By similarity). / S-nitrosylation is induced by interferon-gamma and oxidatively-modified low-densitity lipoprotein (LDL(ox)) possibly implicating the iNOS-S100A8/9 transnitrosylase complex.
|Protein cellular localization|| |
Apical cell membrane / Peripheral membrane protein / Cytoplasmic side / Cell projection / Cell projection > microvillus membrane / Peripheral membrane protein / Cytoplasmic side / Cell projection > ruffle membrane / Peripheral membrane protein / Cytoplasmic side / Cytoplasm > cell cortex / Cytoplasm > cytoskeleton
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St John’s Laboratory Ltd.
|Product type|| |
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