Rabbit Polyclonal Phospho-Fer (Y402) antibody (STJ90943)

$99.00$319.00

Reactivity: Human, Mouse
Applications: WB, IHC, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Rabbit Polyclonal Phospho-Fer (Y402) antibody (STJ90943)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, IHC, ELISA

Recommended dilution: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:20000;

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Fer (phospho Tyr402) Polyclonal Antibody.

Alternative names:

Check alternative names for the antibody

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FER antibody, TYK3 antibody,|c FER antibody|FER antibody|p94 FER antibody|p94-FER antibody|Pe1Fe10 antibody|Pe1Fe13 antibody|Pe1Fe3 antibody|Pe1Fe6 antibody|Phosphoprotein NCP94 antibody|PPP1R74 antibody|Protein phosphatase 1 regulatory subunit 74 antibody|Proto oncogene tyrosine protein kinase FER antibody|Proto-oncogene c-Fer antibody|TYK3 antibody|Tyrosine kinase 3 antibody|Tyrosine-protein kinase Fer antibody|Anti-FER antibody [EP1842Y] (ab52479)
SCBT cat No: sc-81272|sc-81708|sc-81461|sc-390484|sc-28771|

 

Name

Fer (phospho Tyr402) Polyclonal Antibody

Catalogue No.

STJ90943

Reactivity

Human, Mouse

Specificity

Phospho-Fer (Y402) Polyclonal Antibody detects endogenous levels of Fer protein only when phosphorylated at Y402.

Immunogen

Synthesized phospho-peptide derived from Fer (phospho Tyr402) at AA range 340-420

Host

Rabbit

Applications

WB, IHC, ELISA

Recommended dilution

WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:20000;

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

85 kDa

Formulation

Fer (phospho Tyr402) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

Fer (phospho Tyr402) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Tyrosine-protein kinase Fer antibody, Feline encephalitis virus-related kinase FER antibody, Fujinami poultry sarcoma/Feline sarcoma-related protein Fer antibody, Proto-oncogene c-Fer antibody, Tyrosine kinase 3 antibody, p94-Fer antibody

Database links

Human UniProt/Swiss-Prot:P16591;Mouse UniPort/Swiss-Prot: P70451;Rat UniProt/Swiss-Port: P09760;Human Entrez Gene: 2241;Mouse Entrez Gene: 14158;Rat Entrez Gene: Rn.102629

Protein names

Tyrosine-protein kinase Fer , Feline encephalitis virus-related kinase FER , Fujinami poultry sarcoma/Feline sarcoma-related protein Fer , Proto-oncogene c-Fer , Tyrosine kinase 3 , p94-Fer

Protein function

Tyrosine-protein kinase that acts downstream of cell surface receptors for growth factors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, lamellipodia formation, cell adhesion, cell migration and chemotaxis. Acts downstream of EGFR, KIT, PDGFRA and PDGFRB. Acts downstream of EGFR to promote activation of NF-kappa-B and cell proliferation. May play a role in the regulation of the mitotic cell cycle. Plays a role in the insulin receptor signaling pathway and in activation of phosphatidylinositol 3-kinase. Acts downstream of the activated FCER1 receptor and plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Plays a role in the regulation of mast cell degranulation. Plays a role in leukocyte recruitment and diapedesis in response to bacterial lipopolysaccharide (LPS). Plays a role in synapse organization, trafficking of synaptic vesicles, the generation of excitatory postsynaptic currents and neuron-neuron synaptic transmission. Plays a role in neuronal cell death after brain damage. Phosphorylates CTTN, CTNND1, PTK2/FAK1, GAB1, PECAM1 and PTPN11. May phosphorylate JUP and PTPN1. Can phosphorylate STAT3, but the biological relevance of this depends on cell type and stimulus. / ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. / Activated by phosphatidic acid binding. Activated by hydrogen peroxide (in vitro). Activated by reactive oxygen species (ROS).

Protein tissue specificity

Isoform 1 is detected in normal colon and in fibroblasts (at protein level). Isoform 3 is detected in normal testis, in colon carcinoma-derived metastases in lung, liver and ovary, and in colon carcinoma and hepato carcinoma cell lines (at protein level). Isoform 3 is not detected in normal colon or in normal fibroblasts (at protein level). Widely expressed.

Protein sequence and domain

The coiled coil domains mediate homooligomerization and are required for location at microtubules. / The N-terminal region including the first coiled coil domain mediates interaction with phosphoinositide-containing membranes. / Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. / Contains 1 F-BAR domain. / Contains 1 protein kinase domain. / Contains 1 SH2 domain.

Protein post-translational modifications

Autophosphorylated. / Polyubiquitinated; this leads to proteasomal degradation.

Protein cellular localization

Cytoplasm / Cytoplasm > cytoskeleton / Cell membrane; Peripheral membrane protein; Cytoplasmic side / Cell projection / Cell junction / Membrane; Peripheral membrane protein; Cytoplasmic side / Nucleus / Cytoplasm > cell cortex

Research area

All research areas>Kinases and Phosphatases>Fer
(View all antibody categories related to Kinases and Phosphatases)

Note

AntibodyPlus can customize Fer (phospho Tyr402) Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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