Rabbit Polyclonal Phospho-FoxL2 (S263) antibody (STJ90553)

$99.00$319.00

Reactivity: Human, Mouse
Applications: WB, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Rabbit Polyclonal Phospho-FoxL2 (S263) antibody (STJ90553)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, ELISA

Recommended dilution: WB 1:500-1:2000; ELISA 1:20000;

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for FoxL2 (phospho Ser263) Polyclonal Antibody.

Alternative names:

Check alternative names for the antibody

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FOXL2 antibody,|Blepharophimosis antibody|Blepharophimosis epicanthus inversus and ptosis 1 antibody|Blepharophimosis epicanthus inversus and ptosis antibody|BPES 1 antibody|BPES antibody|BPES1 antibody|Epicanthus inversus and ptosis 1 antibody|Forkhead box L2 antibody|Forkhead box protein L2 antibody|Forkhead transcription factor FOXL2 antibody|FOX L2 antibody|FOXL 2 antibody|FOXL2 antibody|FOXL2_HUMAN antibody|PFRK antibody|PINTO antibody|PITUITARY FORKHEAD FACTOR antibody|POF 3 antibody|POF3 antibody|Anti-FOXL2 antibody (ab5096)
SCBT cat No: sc-81275|sc-55655|sc-55657|sc-68348|

 

Name

FoxL2 (phospho Ser263) Polyclonal Antibody

Catalogue No.

STJ90553

Reactivity

Human, Mouse

Specificity

Phospho-FoxL2 (S263) Polyclonal Antibody detects endogenous levels of FoxL2 protein only when phosphorylated at S263.

Immunogen

Synthesized phospho-peptide derived from FoxL2 (phospho Ser263) at AA range 200-280

Host

Rabbit

Applications

WB, ELISA

Recommended dilution

WB 1:500-1:2000; ELISA 1:20000;

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

40 kDa

Formulation

FoxL2 (phospho Ser263) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

FoxL2 (phospho Ser263) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Forkhead box protein L2 antibody

Database links

Human UniProt/Swiss-Prot:P58012;Mouse UniPort/Swiss-Prot: O88470;Rat UniProt/Swiss-Port: D4A0S1;Human Entrez Gene: 668;Mouse Entrez Gene: 26927;

Protein names

Forkhead box protein L2

Protein function

Transcriptional regulator. Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination. Prevents trans-differentiation of ovary to testis through transcriptional repression of the Sertoli cell-promoting gene SOX9 (By similarity). Has apoptotic activity in ovarian cells. Suppresses ESR1-mediated transcription of PTGS2/COX2 stimulated by tamoxifen (By similarity). Is a regulator of CYP19 expression (By similarity). Participates in SMAD3-dependent transcription of FST via the intronic SMAD-binding element (By similarity). Is a transcriptional repressor of STAR. Activates SIRT1 transcription under cellular stress conditions. Activates transcription of OSR2.

Protein tissue specificity

In addition to its expression in the developing eyelid, it is transcribed very early in somatic cells of the developing gonad (before sex determination) and its expression persists in the follicular cells of the adult ovary.

Involvement in disease

Blepharophimosis, ptosis, and epicanthus inversus syndrome (BPES) [MIM:110100]: A disorder characterized by eyelid dysplasia, small palpebral fissures, drooping eyelids and a skin fold curving in the mediolateral direction, inferior to the inner canthus. In type I BPSE (BPES1) eyelid abnormalities are associated with female infertility. Affected females show an ovarian deficit due to primary amenorrhea or to premature ovarian failure (POF). In type II BPSE (BPES2) affected individuals show only the eyelid defects. . Note: The disease is caused by mutations affecting the gene represented in this entry. There is a mutational hotspot in the region coding for the poly-Ala domain, since 30% of all mutations in the ORF lead to poly-Ala expansions, resulting mainly in BPES type II.; Premature ovarian failure 3 (POF3) [MIM:608996]: An ovarian disorder defined as the cessation of ovarian function under the age of 40 years. It is characterized by oligomenorrhea or amenorrhea, in the presence of elevated levels of serum gonadotropins and low estradiol. . Note: The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

Contains 1 fork-head DNA-binding domain.

Protein post-translational modifications

Sumoylated with SUMO1; sumoylation is required for transcriptional repression activity.

Protein cellular localization

Nucleus

Research area

All research areas>Transcription Regulators>FOX
(View all antibody categories related to Transcription Regulators)

Note

AntibodyPlus can customize FoxL2 (phospho Ser263) Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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