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Rabbit Polyclonal Phospho-FoxL2 (S263) antibody (STJ90553)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-1:2000; ELISA 1:20000;
Recommended protocols: check protocols
Click or hover above images to see image description for FoxL2 (phospho Ser263) Polyclonal Antibody.
Check alternative names for the antibodyExpand
FOXL2 antibody,|Blepharophimosis antibody|Blepharophimosis epicanthus inversus and ptosis 1 antibody|Blepharophimosis epicanthus inversus and ptosis antibody|BPES 1 antibody|BPES antibody|BPES1 antibody|Epicanthus inversus and ptosis 1 antibody|Forkhead box L2 antibody|Forkhead box protein L2 antibody|Forkhead transcription factor FOXL2 antibody|FOX L2 antibody|FOXL 2 antibody|FOXL2 antibody|FOXL2_HUMAN antibody|PFRK antibody|PINTO antibody|PITUITARY FORKHEAD FACTOR antibody|POF 3 antibody|POF3 antibody|Anti-FOXL2 antibody (ab5096)
SCBT cat No: sc-81275|sc-55655|sc-55657|sc-68348|
FoxL2 (phospho Ser263) Polyclonal Antibody
|Catalogue No.|| |
Phospho-FoxL2 (S263) Polyclonal Antibody detects endogenous levels of FoxL2 protein only when phosphorylated at S263.
Synthesized phospho-peptide derived from FoxL2 (phospho Ser263) at AA range 200-280
|Recommended dilution|| |
WB 1:500-1:2000; ELISA 1:20000;
|Molecular weight|| |
FoxL2 (phospho Ser263) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
FoxL2 (phospho Ser263) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Forkhead box protein L2 antibody
|Protein names|| |
Forkhead box protein L2
|Protein function|| |
Transcriptional regulator. Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination. Prevents trans-differentiation of ovary to testis through transcriptional repression of the Sertoli cell-promoting gene SOX9 (By similarity). Has apoptotic activity in ovarian cells. Suppresses ESR1-mediated transcription of PTGS2/COX2 stimulated by tamoxifen (By similarity). Is a regulator of CYP19 expression (By similarity). Participates in SMAD3-dependent transcription of FST via the intronic SMAD-binding element (By similarity). Is a transcriptional repressor of STAR. Activates SIRT1 transcription under cellular stress conditions. Activates transcription of OSR2.
|Protein tissue specificity|| |
In addition to its expression in the developing eyelid, it is transcribed very early in somatic cells of the developing gonad (before sex determination) and its expression persists in the follicular cells of the adult ovary.
|Involvement in disease|| |
Blepharophimosis, ptosis, and epicanthus inversus syndrome (BPES) [MIM:110100]: A disorder characterized by eyelid dysplasia, small palpebral fissures, drooping eyelids and a skin fold curving in the mediolateral direction, inferior to the inner canthus. In type I BPSE (BPES1) eyelid abnormalities are associated with female infertility. Affected females show an ovarian deficit due to primary amenorrhea or to premature ovarian failure (POF). In type II BPSE (BPES2) affected individuals show only the eyelid defects. . Note: The disease is caused by mutations affecting the gene represented in this entry. There is a mutational hotspot in the region coding for the poly-Ala domain, since 30% of all mutations in the ORF lead to poly-Ala expansions, resulting mainly in BPES type II.; Premature ovarian failure 3 (POF3) [MIM:608996]: An ovarian disorder defined as the cessation of ovarian function under the age of 40 years. It is characterized by oligomenorrhea or amenorrhea, in the presence of elevated levels of serum gonadotropins and low estradiol. . Note: The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Contains 1 fork-head DNA-binding domain.
|Protein post-translational modifications|| |
Sumoylated with SUMO1; sumoylation is required for transcriptional repression activity.
|Protein cellular localization|| |
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St John’s Laboratory Ltd.
|Product type|| |
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