Rabbit Polyclonal Phospho-FRS2 (Y436) antibody (STJ90965)

$99.00$319.00

Reactivity: Human, Mouse, Monkey
Applications: WB, IHC, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Rabbit Polyclonal Phospho-FRS2 (Y436) antibody (STJ90965)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, IHC, ELISA

Recommended dilution: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:10000;

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for FRS2 (phospho Tyr436) Polyclonal Antibody.

Alternative names:

Check alternative names for the antibody

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FRS2 antibody,|FGFR signaling adaptor SNT antibody|FGFR signalling adaptor antibody|FGFR substrate 2 antibody|FGFR-signaling adaptor SNT antibody|Fibroblast growth factor receptor substrate 2 antibody|FRS 2 antibody|FRS2 antibody|FRS2_HUMAN antibody|FRS2A antibody|FRS2alpha antibody|SNT 1 antibody|SNT antibody|SNT-1 antibody|SNT1 antibody|Suc 1 Associated Neurotrophic Factor Target antibody|Suc1 associated neurotrophic factor target 1 antibody|Suc1-associated neurotrophic factor target 1 antibody|Anti-FRS2 antibody (ab10425)
SCBT cat No: sc-17841|sc-51491|sc-8318|

 

Name

FRS2 (phospho Tyr436) Polyclonal Antibody

Catalogue No.

STJ90965

Reactivity

Human, Mouse, Monkey

Specificity

Phospho-FRS2 (Y436) Polyclonal Antibody detects endogenous levels of FRS2 protein only when phosphorylated at Y436.

Immunogen

Synthesized phospho-peptide derived from FRS2 (phospho Tyr436) at AA range 380-460

Host

Rabbit

Applications

WB, IHC, ELISA

Recommended dilution

WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:10000;

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

65 kDa

Formulation

FRS2 (phospho Tyr436) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

FRS2 (phospho Tyr436) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Fibroblast growth factor receptor substrate 2 antibody, FGFR substrate 2 antibody, FGFR-signaling adaptor SNT antibody, Suc1-associated neurotrophic factor target 1 antibody, SNT-1 antibody

Database links

Human UniProt/Swiss-Prot:Q8WU20;Mouse UniPort/Swiss-Prot: Q8C180;Rat UniProt/Swiss-Port: D4A244;Human Entrez Gene: 10818;Mouse Entrez Gene: 327826;Rat Entrez Gene: Rn.22182

Protein names

Fibroblast growth factor receptor substrate 2 , FGFR substrate 2 , FGFR-signaling adaptor SNT , Suc1-associated neurotrophic factor target 1 , SNT-1

Protein function

Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.

Protein tissue specificity

Highly expressed in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis.

Protein sequence and domain

Contains 1 IRS-type PTB domain.

Protein post-translational modifications

Phosphorylated by ULK2 in vitro (By similarity). Phosphorylated on tyrosine residues upon stimulation by NGF or FGF2. Phosphorylated on tyrosine residues by activated ALK and FGFR1. Phosphorylated on tyrosine residues upon activation of FGFR2 and FGFR3. Phosphorylated on threonine residues by MAP kinases; this inhibits tyrosine phosphorylation, and thereby down-regulates FRS2-mediated activation of MAP kinases. / Ubiquitinated when tyrosine phosphorylated and in a complex with GRB2. The unphosphorylated form is not subject to ubiquitination (By similarity).

Protein cellular localization

Endomembrane system

Research area

All research areas>Signaling Intermediates>FRS
(View all antibody categories related to Signaling Intermediates)

Note

AntibodyPlus can customize FRS2 (phospho Tyr436) Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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