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Rabbit Polyclonal Phospho-FRS2 (Y436) antibody (STJ90965)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IHC, ELISA
Recommended dilution: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:10000;
Recommended protocols: check protocols
Click or hover above images to see image description for FRS2 (phospho Tyr436) Polyclonal Antibody.
Check alternative names for the antibodyExpand
FRS2 antibody,|FGFR signaling adaptor SNT antibody|FGFR signalling adaptor antibody|FGFR substrate 2 antibody|FGFR-signaling adaptor SNT antibody|Fibroblast growth factor receptor substrate 2 antibody|FRS 2 antibody|FRS2 antibody|FRS2_HUMAN antibody|FRS2A antibody|FRS2alpha antibody|SNT 1 antibody|SNT antibody|SNT-1 antibody|SNT1 antibody|Suc 1 Associated Neurotrophic Factor Target antibody|Suc1 associated neurotrophic factor target 1 antibody|Suc1-associated neurotrophic factor target 1 antibody|Anti-FRS2 antibody (ab10425)
SCBT cat No: sc-17841|sc-51491|sc-8318|
FRS2 (phospho Tyr436) Polyclonal Antibody
|Catalogue No.|| |
Human, Mouse, Monkey
Phospho-FRS2 (Y436) Polyclonal Antibody detects endogenous levels of FRS2 protein only when phosphorylated at Y436.
Synthesized phospho-peptide derived from FRS2 (phospho Tyr436) at AA range 380-460
WB, IHC, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:10000;
|Molecular weight|| |
FRS2 (phospho Tyr436) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
FRS2 (phospho Tyr436) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Fibroblast growth factor receptor substrate 2 antibody, FGFR substrate 2 antibody, FGFR-signaling adaptor SNT antibody, Suc1-associated neurotrophic factor target 1 antibody, SNT-1 antibody
|Protein names|| |
Fibroblast growth factor receptor substrate 2 , FGFR substrate 2 , FGFR-signaling adaptor SNT , Suc1-associated neurotrophic factor target 1 , SNT-1
|Protein function|| |
Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.
|Protein tissue specificity|| |
Highly expressed in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis.
|Protein sequence and domain|| |
Contains 1 IRS-type PTB domain.
|Protein post-translational modifications|| |
Phosphorylated by ULK2 in vitro (By similarity). Phosphorylated on tyrosine residues upon stimulation by NGF or FGF2. Phosphorylated on tyrosine residues by activated ALK and FGFR1. Phosphorylated on tyrosine residues upon activation of FGFR2 and FGFR3. Phosphorylated on threonine residues by MAP kinases; this inhibits tyrosine phosphorylation, and thereby down-regulates FRS2-mediated activation of MAP kinases. / Ubiquitinated when tyrosine phosphorylated and in a complex with GRB2. The unphosphorylated form is not subject to ubiquitination (By similarity).
|Protein cellular localization|| |
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St John’s Laboratory Ltd.
|Product type|| |
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