Rabbit Polyclonal Phospho-Gab 2 (S623) antibody (STJ90978)

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Reactivity: Human, Mouse, Rat
Applications: WB, IHC, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Rabbit Polyclonal Phospho-Gab 2 (S623) antibody (STJ90978)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, IHC, ELISA

Recommended dilution: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:5000;

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Gab 2 (phospho Ser623) Polyclonal Antibody.

Alternative names:

Check alternative names for the antibody

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GAB2 antibody, KIAA0571 antibody,|GAB 2 antibody|Gab2 antibody|GAB2_HUMAN antibody|Grb 2 associated binder 2 antibody|GRB 2 associated binding protein 2 antibody|Grb2 associated binder 2 antibody|GRB2 associated binder 2 pp100 antibody|GRB2 associated binding protein 2 antibody|GRB2-associated binder 2 antibody|GRB2-associated-binding protein 2 antibody|Growth factor receptor bound protein 2 associated protein 2 antibody|Growth factor receptor bound protein 2-associated protein 2 antibody|KIAA0571 antibody|p97 antibody|PH domain containing adaptor molecule p97 antibody|pp100 antibody|Anti-GAB2 antibody [EP369Y] (ab32365)
SCBT cat No: sc-25498|sc-365590|sc-9313|

 

Name

Gab 2 (phospho Ser623) Polyclonal Antibody

Catalogue No.

STJ90978

Reactivity

Human, Mouse, Rat

Specificity

Phospho-Gab 2 (S623) Polyclonal Antibody detects endogenous levels of Gab 2 protein only when phosphorylated at S623.

Immunogen

Synthesized phospho-peptide derived from Gab 2 (phospho Ser623) at AA range 560-640

Host

Rabbit

Applications

WB, IHC, ELISA

Recommended dilution

WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:5000;

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

80 kDa

Formulation

Gab 2 (phospho Ser623) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

Gab 2 (phospho Ser623) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

GRB2-associated-binding protein 2 antibody, GRB2-associated binder 2 antibody, Growth factor receptor bound protein 2-associated protein 2 antibody, pp100 antibody

Database links

Human UniProt/Swiss-Prot:Q9UQC2;Rat UniProt/Swiss-Port: Q9EQH1;Human Entrez Gene: 9846;Mouse Entrez Gene: 14389;Rat Entrez Gene: Rn.211990

Protein names

GRB2-associated-binding protein 2 , GRB2-associated binder 2 , Growth factor receptor bound protein 2-associated protein 2 , pp100

Protein function

Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis.

Protein sequence and domain

The SH3-binding motifs mediate interaction with SHC1 and GRB2. / The PH domain mediates phosphatidylinositol 3,4,5-trisphosphate and phosphatidylinositol 3,4-bisphosphate binding. / Belongs to the GAB family. / Contains 1 PH domain.

Protein post-translational modifications

Phosphorylated on tyrosine residue(s) by the thrombopoietin receptor (TPOR), stem cell factor receptor (SCFR), and T-cell and B-cell antigen receptors, gp130, IL-2R and IL-3R (By similarity). Phosphorylated upon stimulation of TNFRSF11A/RANK by TNFSF11/RANKL (By similarity). Phosphorylated upon EGF stimulation. Phosphorylated on tyrosine residues by HCK upon IL6 signaling. / Dephosphorylated by PTPN11.

Protein cellular localization

Cytoplasm / Cell membrane

Research area

All research areas>Signaling Intermediates>Gab
(View all antibody categories related to Signaling Intermediates)

Note

AntibodyPlus can customize Gab 2 (phospho Ser623) Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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