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Rabbit Polyclonal Phospho-Gab 2 (Y643) antibody (STJ90977)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IHC, ELISA
Recommended dilution: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:40000;
Recommended protocols: check protocols
Click or hover above images to see image description for Gab 2 (phospho Tyr643) Polyclonal Antibody.
Check alternative names for the antibodyExpand
GAB2 antibody, KIAA0571 antibody,|GAB 2 antibody|Gab2 antibody|GAB2_HUMAN antibody|Grb 2 associated binder 2 antibody|GRB 2 associated binding protein 2 antibody|Grb2 associated binder 2 antibody|GRB2 associated binder 2 pp100 antibody|GRB2 associated binding protein 2 antibody|GRB2-associated binder 2 antibody|GRB2-associated-binding protein 2 antibody|Growth factor receptor bound protein 2 associated protein 2 antibody|Growth factor receptor bound protein 2-associated protein 2 antibody|KIAA0571 antibody|p97 antibody|PH domain containing adaptor molecule p97 antibody|pp100 antibody|Anti-GAB2 antibody [EP369Y] (ab32365)
SCBT cat No: sc-25498|sc-365590|sc-9313|
Gab 2 (phospho Tyr643) Polyclonal Antibody
|Catalogue No.|| |
Human, Mouse, Rat
Phospho-Gab 2 (Y643) Polyclonal Antibody detects endogenous levels of Gab 2 protein only when phosphorylated at Y643.
Synthesized phospho-peptide derived from Gab 2 (phospho Tyr643) at AA range 580-660
WB, IHC, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:40000;
|Molecular weight|| |
Gab 2 (phospho Tyr643) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gab 2 (phospho Tyr643) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
GRB2-associated-binding protein 2 antibody, GRB2-associated binder 2 antibody, Growth factor receptor bound protein 2-associated protein 2 antibody, pp100 antibody
|Protein names|| |
GRB2-associated-binding protein 2 , GRB2-associated binder 2 , Growth factor receptor bound protein 2-associated protein 2 , pp100
|Protein function|| |
Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis.
|Protein sequence and domain|| |
The SH3-binding motifs mediate interaction with SHC1 and GRB2. / The PH domain mediates phosphatidylinositol 3,4,5-trisphosphate and phosphatidylinositol 3,4-bisphosphate binding. / Belongs to the GAB family. / Contains 1 PH domain.
|Protein post-translational modifications|| |
Phosphorylated on tyrosine residue(s) by the thrombopoietin receptor (TPOR), stem cell factor receptor (SCFR), and T-cell and B-cell antigen receptors, gp130, IL-2R and IL-3R (By similarity). Phosphorylated upon stimulation of TNFRSF11A/RANK by TNFSF11/RANKL (By similarity). Phosphorylated upon EGF stimulation. Phosphorylated on tyrosine residues by HCK upon IL6 signaling. / Dephosphorylated by PTPN11.
|Protein cellular localization|| |
Cytoplasm / Cell membrane
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St John’s Laboratory Ltd.
|Product type|| |
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