Rabbit Polyclonal Phospho-GAB1-Y627 antibody (AP0256)

$99.00$259.00

Reactivity: Human,Mouse
Applications: WB,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit Polyclonal Phospho-GAB1-Y627 antibody (AP0256)

Supplier: ABclonal Inc.

Recommended applications: WB,IF

Recommended dilution:

WB 1:500 – 1:2000
IF 1:100 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

Expand

Gab 1 antibody|GAB1 antibody|GAB1_HUMAN antibody|GRB 2 associated binder 1 antibody|GRB 2 associated binding protein 1 antibody|GRB2 associated binding protein 1 isoform a antibody|GRB2 associated binding protein 1 isoform b antibody|GRB2-associated binder 1 antibody|GRB2-associated-binding protein 1 antibody|Growth factor receptor bound protein 2-associated protein 1 antibody|Anti-GAB1 antibody (ab59362)

SCBT cat No: sc-6292|sc-271848|sc-9049|sc-133191|sc-25498|

Name

Rabbit Polyclonal Phospho-GAB1-Y627 antibody

Catalogue No.

AP0256

Reactivity

Human, Mouse

Immunogen

A phospho specific peptide corresponding to residues surrounding Y627 of human GAB1

Host

Rabbit

Applications

WB, IF

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

110kDa

Formulation

Phospho-GAB1-Y627 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

Affinity purification

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Protein function

Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR).

Protein sequence and domain

Belongs to the GAB family.; Contains 1 PH domain.

Protein post-translational modifications

Phosphorylated in response to FGFR1 activation. Phosphorylated on tyrosine residue(s) by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Tyrosine phosphorylation of GAB1 mediates interaction with several proteins that contain SH2 domains. Phosphorylated on tyrosine residues by HCK upon IL6 signaling.

Background

The protein encoded by this gene is a member of the IRS1-like multisubstrate docking protein family. It is an important mediator of branching tubulogenesis and plays a central role in cellular growth response, transformation and apoptosis. Two transcript variants encoding different isoforms have been found for this gene.

Research area

<a href="http://antibodyplus.com/research-areas/">All research areas</a>><a href="http://antibodyplus.com/Signaling-Intermediates/">Signaling Intermediates</a>><a href="http://antibodyplus.com/product-tag/Gab/">Gab</a><br><a href="http://antibodyplus.com/product-tag/Signaling-Intermediates/"&gt; (View all antibody categories related to Signaling Intermediates)</a>

Note

AntibodyPlus can customize Phospho-GAB1-Y627 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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