Rabbit Polyclonal Phospho-GJA1-S367 antibody (AP0355)

$99.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit Polyclonal Phospho-GJA1-S367 antibody (AP0355)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000
IHC 1:50 – 1:100

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

Expand

HSS antibody; CMDR antibody; CX43 antibody; GJAL antibody; ODDD antibody; AVSD3 antibody; HLHS1 antibody; DFNB38 antibody;
Connexin 43 antibody|Connexin-43 antibody|Cx 43 antibody|Cx43 antibody|CXA1_HUMAN antibody|DFNB38 antibody|Gap junction 43 kDa heart protein antibody|Gap junction alpha-1 protein antibody|Gap junction protein alpha 1 43kDa (connexin 43) antibody|Gap junction protein alpha 1 43kDa antibody|Gap junction protein alpha like antibody|GJA 1 antibody|Gja1 antibody|GJAL antibody|ODD antibody|ODDD antibody|ODOD antibody|SDTY3 antibody|Anti-Connexin 43 / GJA1 antibody (ab11370)

SCBT cat No: sc-17219|sc-22267|

Name

Rabbit Polyclonal Phospho-GJA1-S367 antibody

Catalogue No.

AP0355

Reactivity

Human, Mouse, Rat

Immunogen

A phospho specific peptide corresponding to residues surrounding S368 of human GJA1

Host

Rabbit

Applications

WB, IHC

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

43kDa

Formulation

Phospho-GJA1-S367 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

Affinity purification

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

HSS antibody; CMDR antibody; CX43 antibody; GJAL antibody; ODDD antibody; AVSD3 antibody; HLHS1 antibody; DFNB38 antibody;

Protein names

HSS; CMDR; CX43; GJAL; ODDD; AVSD3; HLHS1; DFNB38;

Protein function

Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract (By similarity). May play a role in cell growth inhibition through the regulation of NOV expression and localization. Plays an essential role in gap junction communication in the ventricles (By similarity).

Protein tissue specificity

Expressed in the heart and fetal cochlea.

Protein sequence and domain

Belongs to the connexin family. Alpha-type (group II) subfamily.

Protein post-translational modifications

Phosphorylated at Ser-368 by PRKCG; phosphorylation induces disassembly of gap junction plaques and inhibition of gap junction activity (By similarity). Phosphorylation at Ser-325, Ser-328 and Ser-330 by CK1 modulates gap junction assembly. Phosphorylation at Ser-368 by PRKCD triggers its internalization into small vesicles leading to proteasome-mediated degradation (By similarity).; Sumoylated with SUMO1, SUMO2 and SUMO3, which may regulate the level of functional Cx43 gap junctions at the plasma membrane. May be desumoylated by SENP1 or SENP2.; S-nitrosylation at Cys-271 is enriched at the muscle endothelial gap junction in arteries, it augments channel permeability and may regulate of smooth muscle cell to endothelial cell communication.

Protein cellular localization

Cell membrane ; Multi-pass membrane protein . Cell junction, gap junction . Endoplasmic reticulum . Note=Localizes at the intercalated disk (ICD) in cardiomyocytes and the proper localization at ICD is dependent on TMEM65.

Background

This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. The encoded protein is the major protein of gap junctions in the heart that are thought to have a crucial role in the synchronized contraction of the heart and in embryonic development. A related intronless pseudogene has been mapped to chromosome 5. Mutations in this gene have been associated with oculodentodigital dysplasia and heart malformations.

Research area

<a href="http://antibodyplus.com/research-areas/">All research areas</a>><a href="http://antibodyplus.com/Cell-Adhesion-Proteins/">Cell Adhesion Proteins</a>><a href="http://antibodyplus.com/product-tag/Connexin/">Connexin</a><br><a href="http://antibodyplus.com/product-tag/Cell-Adhesion-Proteins/"&gt; (View all antibody categories related to Cell Adhesion Proteins)</a>

Note

AntibodyPlus can customize Phospho-GJA1-S367 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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