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Rabbit Polyclonal Phospho-GluR4 (S862) antibody (STJ90900)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IHC, ELISA
Recommended dilution: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:5000;
Recommended protocols: check protocols
Click or hover above images to see image description for GluR4 (phospho Ser862) Polyclonal Antibody.
Check alternative names for the antibodyExpand
GRIA4 antibody, GLUR4 antibody,|AMPA 4 antibody|AMPA selective glutamate receptor 4 antibody|AMPA-selective glutamate receptor 4 antibody|AMPA4 antibody|GluA 4 antibody|GluA4 antibody|GluR 4 antibody|GluR D antibody|GluR-4 antibody|GluR-D antibody|GluR4 antibody|GLUR4C antibody|GLURD antibody|Glutamate receptor 4 antibody|Glutamate receptor ionotrophic AMPA 4 antibody|Glutamate receptor ionotropic antibody|GRIA 4 antibody|Gria4 antibody|GRIA4_HUMAN antibody|Anti-Ionotropic Glutamate receptor 4 antibody (ab77407)
SCBT cat No: sc-7614|sc-271894|sc-31394|
GluR4 (phospho Ser862) Polyclonal Antibody
|Catalogue No.|| |
Human, Mouse, Rat
Phospho-GluR4 (S862) Polyclonal Antibody detects endogenous levels of GluR4 protein only when phosphorylated at S862.
Synthesized phospho-peptide derived from GluR4 (phospho Ser862) at AA range 800-880
WB, IHC, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:5000;
|Molecular weight|| |
GluR4 (phospho Ser862) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
GluR4 (phospho Ser862) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Glutamate receptor 4 antibody, GluR-4 antibody, GluR4 antibody, AMPA-selective glutamate receptor 4 antibody, GluR-D antibody, Glutamate receptor ionotropic, AMPA 4 antibody, GluA4 antibody
|Protein names|| |
Glutamate receptor 4 , GluR-4 , GluR4 , AMPA-selective glutamate receptor 4 , GluR-D , Glutamate receptor ionotropic, AMPA 4 , GluA4
|Protein function|| |
Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.
|Protein sequence and domain|| |
The M4 transmembrane segment mediates tetramerization and is required for cell surface expression. / Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIA4 subfamily. [View classification]
|Protein post-translational modifications|| |
Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-611 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast, Cys-837 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis (By similarity). / Phosphorylated at Ser-862 by PRKCG; phosphorylation increases plasma membrane-associated GRI4 expression.
|Protein cellular localization|| |
Cell membrane; Multi-pass membrane protein / Cell junction > synapse > postsynaptic cell membrane; Multi-pass membrane protein / Cell projection > dendrite
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St John’s Laboratory Ltd.
|Product type|| |
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