Rabbit Polyclonal Phospho-Glycogen Synthase 1 (S645) antibody (STJ90793)

$99.00$319.00

Reactivity: Human, Mouse, Rat
Applications: WB, IHC, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Rabbit Polyclonal Phospho-Glycogen Synthase 1 (S645) antibody (STJ90793)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, IHC, ELISA

Recommended dilution: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:5000;

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Glycogen Synthase 1 (phospho Ser645) Polyclonal Antibody.

Alternative names:

Check alternative names for the antibody

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GYS1 antibody, GYS antibody,|Glycogen [starch] synthase antibody|Glycogen synthase 1 (muscle) antibody|Glycogen synthase 1 antibody|GSY antibody|GYS antibody|Gys1 antibody|GYS1_HUMAN antibody|muscle antibody|Anti-Glycogen synthase 1 antibody [EP817Y] (ab40810)
SCBT cat No: sc-47188|

 

Name

Glycogen Synthase 1 (phospho Ser645) Polyclonal Antibody

Catalogue No.

STJ90793

Reactivity

Human, Mouse, Rat

Specificity

Phospho-Glycogen Synthase 1 (S645) Polyclonal Antibody detects endogenous levels of Glycogen Synthase 1 protein only when phosphorylated at S645.

Immunogen

Synthesized phospho-peptide derived from Glycogen Synthase 1 (phospho Ser645) at AA range 580-660

Host

Rabbit

Applications

WB, IHC, ELISA

Recommended dilution

WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:5000;

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

83/89 kDa

Formulation

Glycogen Synthase 1 (phospho Ser645) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

Glycogen Synthase 1 (phospho Ser645) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Glycogen synthase, muscle antibody,

Database links

Human UniProt/Swiss-Prot:P13807;Mouse UniPort/Swiss-Prot: Q9Z1E4;Rat UniProt/Swiss-Port: A2RRU1;Human Entrez Gene: 2997;Mouse Entrez Gene: 14936;Rat Entrez Gene: Rn.95278

Protein names

Glycogen synthase, muscle ,

Protein function

Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan. / UDP-alpha-D-glucose + ((1->4)-alpha-D-glucosyl)(n) = UDP + ((1->4)-alpha-D-glucosyl)(n+1). / Allosteric activation by glucose-6-phosphate. Phosphorylation reduces the activity towards UDP-glucose. When in the non-phosphorylated state, glycogen synthase does not require glucose-6-phosphate as an allosteric activator; when phosphorylated it does (By similarity). /

Involvement in disease

Muscle glycogen storage disease 0 (GSD0b) [MIM:611556]: Metabolic disorder characterized by fasting hypoglycemia presenting in infancy or early childhood. The role of muscle glycogen is to provide critical energy during bursts of activity and sustained muscle work. . Note: The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

Belongs to the glycosyltransferase 3 family.

Protein post-translational modifications

Phosphorylation at Ser-8 by AMPK inactivates the enzyme activity. Primed phosphorylation at Ser-657 (site 5) by CSNK2A1 and CSNK2A2 is required for inhibitory phosphorylation at Ser-641 (site 3a), Ser-645 (site 3b), Ser-649 (site 3c) and Ser-653 (site 4) by GSK3A an GSK3B (By similarity). Phosphorylated at Ser-641 by DYRK2, leading to inactivation (By similarity). Phosphorylated at Ser-641 by PASK, leading to inactivation; phosphorylation by PASK is inhibited by glycogen. Dephosphorylation at Ser-641 and Ser-645 by PP1 activates the enzyme.

Research area

All research areas>Synthesis and Degradation>Glycogen Synthase
(View all antibody categories related to Synthesis and Degradation)

Note

AntibodyPlus can customize Glycogen Synthase 1 (phospho Ser645) Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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