Rabbit Polyclonal Phospho-GRB10 (Y67) antibody (STJ90717)

$99.00$319.00

Reactivity: Human
Applications: WB, IHC, IF, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Rabbit Polyclonal Phospho-GRB10 (Y67) antibody (STJ90717)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, IHC, IF, ELISA

Recommended dilution: WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:20000;

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for GRB10 (phospho Tyr67) Polyclonal Antibody.

Alternative names:

Check alternative names for the antibody

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GRB10 antibody, GRBIR antibody, KIAA0207 antibody,|grb 10 antibody|GRB IR antibody|grb-10 antibody|GRB10 adapter protein antibody|GRB10 adaptor protein antibody|GRB10 antibody|GRB10_HUMAN antibody|GRBIR antibody|Growth factor receptor bound protein 10 antibody|Growth factor receptor-bound protein 10 antibody|Insulin receptor binding protein antibody|Insulin receptor binding protein GRB IR antibody|Insulin receptor-binding protein Grb-IR antibody|IRBP antibody|KIAA0207 antibody|Maternally expressed gene 1 antibody|MEG1 antibody|RSS antibody|Anti-GRB10 antibody (ab217687)
SCBT cat No: sc-74509|sc-74508|sc-13955|sc-1026|

 

Name

GRB10 (phospho Tyr67) Polyclonal Antibody

Catalogue No.

STJ90717

Reactivity

Human

Specificity

Phospho-GRB10 (Y67) Polyclonal Antibody detects endogenous levels of GRB10 protein only when phosphorylated at Y67.

Immunogen

Synthesized phospho-peptide derived from GRB10 (phospho Tyr67) at AA range 10-90

Host

Rabbit

Applications

WB, IHC, IF, ELISA

Recommended dilution

WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:20000;

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

67 kDa

Formulation

GRB10 (phospho Tyr67) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

GRB10 (phospho Tyr67) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Growth factor receptor-bound protein 10 antibody, GRB10 adapter protein antibody, Insulin receptor-binding protein Grb-IR antibody

Database links

Human UniProt/Swiss-Prot:Q13322;Mouse UniPort/Swiss-Prot: Q60760;Rat UniProt/Swiss-Port: D3ZEA3;Human Entrez Gene: 2887;Mouse Entrez Gene: 14783;Rat Entrez Gene: Rn.63942

Protein names

Growth factor receptor-bound protein 10 , GRB10 adapter protein , Insulin receptor-binding protein Grb-IR

Protein function

Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin-stimulated IRS1 and IRS2 tyrosine phosphorylation. Recruits NEDD4 to IGF1R, leading to IGF1R ubiquitination, increased internalization and degradation by both the proteasomal and lysosomal pathways. May play a role in mediating insulin-stimulated ubiquitination of INSR, leading to proteasomal degradation. Negatively regulates Wnt signaling by interacting with LRP6 intracellular portion and interfering with the binding of AXIN1 to LRP6. Positive regulator of the KDR/VEGFR-2 signaling pathway. May inhibit NEDD4-mediated degradation of KDR/VEGFR-2. / Phosphorylation by mTORC1 stabilizes and activates GRB10 constituting a feedback pathway by which mTORC1 inhibits INSR-dependent signaling.

Protein tissue specificity

Widely expressed in fetal and adult tissues, including fetal and postnatal liver, lung, kidney, skeletal muscle, heart, spleen, skin and brain.

Protein sequence and domain

The PH domain binds relatively non-specifically to several phosphoinositides, including PI5P, PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3, with modest affinities. / Belongs to the GRB7/10/14 family. / Contains 1 PH domain. / Contains 1 Ras-associating domain. / Contains 1 SH2 domain.

Protein post-translational modifications

Phosphorylated on serine residues upon EGF, FGF and PDGF stimulation (By similarity). Phosphorylated at Tyr-67 by TEC.

Protein cellular localization

Cytoplasm

Research area

All research areas>Signaling Intermediates>GRB
(View all antibody categories related to Signaling Intermediates)

Note

AntibodyPlus can customize GRB10 (phospho Tyr67) Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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