Rabbit Polyclonal Phospho-GRIA2-S880 antibody (AP0257)

$99.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit Polyclonal Phospho-GRIA2-S880 antibody (AP0257)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:500 – 1:2000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

Expand

GLUR2 antibody; GLURB antibody; GluA2 antibody; HBGR2 antibody; GluR-K2 antibody;
AMPA 2 antibody|AMPA selective glutamate receptor 2 antibody|AMPA-selective glutamate receptor 2 antibody|AMPA2 antibody|GluA2 antibody|GLUR 2 antibody|GLUR B antibody|GluR K2 antibody|GluR-2 antibody|GluR-B antibody|GluR-K2 antibody|GLUR2 antibody|GLURB antibody|Glutamate receptor 2 antibody|Glutamate receptor ionotropic AMPA 2 antibody|Glutamate receptor ionotropic antibody|Gria2 antibody|GRIA2_HUMAN antibody|HBGR2 antibody|Anti-Ionotropic Glutamate receptor 2 antibody [S21-32] (ab106515)

SCBT cat No: sc-33612|sc-7610|sc-7611|sc-517202|sc-7612|sc-7613|

Name

Rabbit Polyclonal Phospho-GRIA2-S880 antibody

Catalogue No.

AP0257

Reactivity

Human, Mouse, Rat

Immunogen

A phospho specific peptide corresponding to residues surrounding S880 of human GRIA2

Host

Rabbit

Applications

WB

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

100kDa

Formulation

Phospho-GRIA2-S880 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

Affinity purification

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

GLUR2 antibody; GLURB antibody; GluA2 antibody; HBGR2 antibody; GluR-K2 antibody;

Protein names

GLUR2; GLURB; GluA2; HBGR2; GluR-K2;

Protein function

Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.

Protein sequence and domain

Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIA2 subfamily. The M4 transmembrane segment mediates tetramerization and is required for cell surface expression.

Protein post-translational modifications

Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-610 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast, Cys-836 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis (By similarity).

Protein cellular localization

Cell membrane ; Multi-pass membrane protein . Endoplasmic reticulum membrane ; Multi-pass membrane protein . Cell junction, synapse, postsynaptic cell membrane ; Multi-pass membrane protein . Note=Interaction with CACNG2, CNIH2 and CNIH3 promotes cell surface expression.

Background

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, GRIA1-4. The subunit encoded by this gene (GRIA2) is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Human and animal studies suggest that pre-mRNA editing is essential for brain function, and defective GRIA2 RNA editing at the Q/R site may be relevant to amyotrophic lateral sclerosis (ALS) etiology. Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip and flop isoforms that vary in their signal transduction properties), has been noted for this gene.

Research area

<a href="http://antibodyplus.com/research-areas/">All research areas</a>><a href="http://antibodyplus.com/Channel-Proteins/">Channel Proteins</a>><a href="http://antibodyplus.com/product-tag/GluR/">GluR</a><br><a href="http://antibodyplus.com/product-tag/Channel-Proteins/"&gt; (View all antibody categories related to Channel Proteins)</a>

Note

AntibodyPlus can customize Phospho-GRIA2-S880 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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