Rabbit Polyclonal Phospho-GRIN1-S896 antibody (AP0165)

$99.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit Polyclonal Phospho-GRIN1-S896 antibody (AP0165)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:500 – 1:2000

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit Polyclonal Phospho-GRIN1-S896 antibody.

Alternative names:

Check alternative names for the antibody

Expand

NR1 antibody; MRD8 antibody; GluN1 antibody; NMDA1 antibody; NMDAR1 antibody;
GluN1 antibody|Glutamate [NMDA] receptor subunit zeta-1 antibody|Glutamate receptor ionotropic N methyl D aspartate 1 antibody|Glutamate receptor ionotropic, N-methyl-D aspartate, subunit 1 antibody|glutamate receptor ionotropic, NMDA 1 antibody|Grin1 antibody|MRD8 antibody|N methyl D aspartate receptor antibody|N methyl D aspartate receptor channel subunit zeta 1 antibody|N methyl D aspartate receptor subunit NR1 antibody|N-methyl-D-aspartate receptor subunit NR1 antibody|NMD-R1 antibody|NMDA 1 antibody|NMDA R1 antibody|NMDA receptor 1 antibody|NMDA1 antibody|NMDAR antibody|NMDZ1_HUMAN antibody|NR1 antibody|Anti-NMDAR1 antibody – Neuronal Marker (ab17345)

SCBT cat No: sc-1467|sc-9058|sc-138479|sc-138481|sc-9484|

Name

Rabbit Polyclonal Phospho-GRIN1-S896 antibody

Catalogue No.

AP0165

Reactivity

Human, Mouse, Rat

Immunogen

A phospho specific peptide corresponding to residues surrounding S896 of human GRIN1

Host

Rabbit

Applications

WB

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

120kDa

Formulation

Phospho-GRIN1-S896 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

Affinity purification

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

NR1 antibody; MRD8 antibody; GluN1 antibody; NMDA1 antibody; NMDAR1 antibody;

Protein names

NR1; MRD8; GluN1; NMDA1; NMDAR1;

Protein function

NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. This protein plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors (By similarity).

Protein sequence and domain

Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR1/GRIN1 subfamily.

Protein post-translational modifications

NMDA is probably regulated by C-terminal phosphorylation of an isoform of NR1 by PKC. Dephosphorylated on Ser-897 probably by protein phosphatase 2A (PPP2CB). Its phosphorylated state is influenced by the formation of the NMDAR-PPP2CB complex and the NMDAR channel activity.

Protein cellular localization

Cell membrane ; Multi-pass membrane protein . Cell junction, synapse, postsynaptic cell membrane . Cell junction, synapse, postsynaptic cell membrane, postsynaptic density . Note=Enriched in postsynaptic plasma membrane and postsynaptic densities.

Background

The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits. Alternatively spliced transcript variants have been described.

Note

AntibodyPlus can customize Phospho-GRIN1-S896 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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