Rabbit Polyclonal Phospho-GRIP-1 (S736) antibody (STJ90985)

$99.00$319.00

Reactivity: Human
Applications: WB, IHC, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Rabbit Polyclonal Phospho-GRIP-1 (S736) antibody (STJ90985)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, IHC, ELISA

Recommended dilution: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:5000;

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for GRIP-1 (phospho Ser736) Polyclonal Antibody.

Alternative names:

Check alternative names for the antibody

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NCOA2 antibody, BHLHE75 antibody, SRC2 antibody, TIF2 antibody,|bHLHe75 antibody|Class E basic helix-loop-helix protein 75 antibody|glucocorticoid receptor interacting protein 1 antibody|GRIP 1 antibody|GRIP1 antibody|hTIF2 antibody|MED1 antibody|MGC138808 antibody|NCoA 2 antibody|NCoA-2 antibody|Ncoa2 antibody|NCOA2_HUMAN antibody|Nuclear receptor coactivator 2 antibody|Oncogene FGR antibody|p160 antibody|SRC 2 antibody|src2 antibody|Steroid receptor coactivator 2 antibody|TIF 2 antibody|TIF2 antibody|Transcriptional intermediary factor 2 antibody|Anti-KAT13C / NCOA2 antibody – ChIP Grade (ab9261)
SCBT cat No: sc-136244|sc-135931|sc-17643|sc-6976|sc-365827|sc-6264|

 

Name

GRIP-1 (phospho Ser736) Polyclonal Antibody

Catalogue No.

STJ90985

Reactivity

Human

Specificity

Phospho-GRIP-1 (S736) Polyclonal Antibody detects endogenous levels of GRIP-1 protein only when phosphorylated at S736.

Immunogen

Synthesized phospho-peptide derived from GRIP-1 (phospho Ser736) at AA range 680-760

Host

Rabbit

Applications

WB, IHC, ELISA

Recommended dilution

WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:5000;

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

180 kDa

Formulation

GRIP-1 (phospho Ser736) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

GRIP-1 (phospho Ser736) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Nuclear receptor coactivator 2 antibody, NCoA-2 antibody, Class E basic helix-loop-helix protein 75 antibody, bHLHe75 antibody, Transcriptional intermediary factor 2 antibody, hTIF2 antibody

Database links

Human UniProt/Swiss-Prot:Q15596;Mouse UniPort/Swiss-Prot: Q61026;Rat UniProt/Swiss-Port: Q9WUI9;Human Entrez Gene: 10499;Mouse Entrez Gene: 17978;Rat Entrez Gene: Rn.49136

Protein names

Nuclear receptor coactivator 2 , NCoA-2 , Class E basic helix-loop-helix protein 75 , bHLHe75 , Transcriptional intermediary factor 2 , hTIF2

Protein function

Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues. Critical regulator of glucose metabolism regulation, acts as RORA coactivator to specifically modulate G6PC expression. Involved in the positive regulation of the transcriptional activity of the glucocorticoid receptor NR3C1 by sumoylation enhancer RWDD3. Positively regulates the circadian clock by acting as a transcriptional coactivator for the CLOCK-ARNTL/BMAL1 heterodimer (By similarity).

Involvement in disease

Note: Chromosomal aberrations involving NCOA2 may be a cause of acute myeloid leukemias. Inversion inv(8)(p11;q13) generates the KAT6A-NCOA2 oncogene, which consists of the N-terminal part of KAT6A and the C-terminal part of NCOA2/TIF2. KAT6A-NCOA2 binds to CREBBP and disrupts its function in transcription activation. .

Protein sequence and domain

Contains four Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs. The LXXLL motifs are essential for the association with nuclear receptors and are, at least in part, functionally redundant. / The LLXXLXXXL motif is involved in transcriptional coactivation and CREBBP/CBP binding. / Contains 2 C-terminal transcription activation domains (AD1 and AD2) that can function independently. / Belongs to the SRC/p160 nuclear receptor coactivator family. / Contains 1 bHLH (basic helix-loop-helix) domain. / Contains 1 PAS (PER-ARNT-SIM) domain.

Protein cellular localization

Nucleus

Research area

All research areas>Steroid Receptors>GRIP-1
(View all antibody categories related to Steroid Receptors)

Note

AntibodyPlus can customize GRIP-1 (phospho Ser736) Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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