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Rabbit Polyclonal Phospho-GRIP-1 (S736) antibody (STJ90985)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IHC, ELISA
Recommended dilution: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:5000;
Recommended protocols: check protocols
Click or hover above images to see image description for GRIP-1 (phospho Ser736) Polyclonal Antibody.
Check alternative names for the antibodyExpand
NCOA2 antibody, BHLHE75 antibody, SRC2 antibody, TIF2 antibody,|bHLHe75 antibody|Class E basic helix-loop-helix protein 75 antibody|glucocorticoid receptor interacting protein 1 antibody|GRIP 1 antibody|GRIP1 antibody|hTIF2 antibody|MED1 antibody|MGC138808 antibody|NCoA 2 antibody|NCoA-2 antibody|Ncoa2 antibody|NCOA2_HUMAN antibody|Nuclear receptor coactivator 2 antibody|Oncogene FGR antibody|p160 antibody|SRC 2 antibody|src2 antibody|Steroid receptor coactivator 2 antibody|TIF 2 antibody|TIF2 antibody|Transcriptional intermediary factor 2 antibody|Anti-KAT13C / NCOA2 antibody – ChIP Grade (ab9261)
SCBT cat No: sc-136244|sc-135931|sc-17643|sc-6976|sc-365827|sc-6264|
GRIP-1 (phospho Ser736) Polyclonal Antibody
|Catalogue No.|| |
Phospho-GRIP-1 (S736) Polyclonal Antibody detects endogenous levels of GRIP-1 protein only when phosphorylated at S736.
Synthesized phospho-peptide derived from GRIP-1 (phospho Ser736) at AA range 680-760
WB, IHC, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:5000;
|Molecular weight|| |
GRIP-1 (phospho Ser736) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
GRIP-1 (phospho Ser736) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Nuclear receptor coactivator 2 antibody, NCoA-2 antibody, Class E basic helix-loop-helix protein 75 antibody, bHLHe75 antibody, Transcriptional intermediary factor 2 antibody, hTIF2 antibody
|Protein names|| |
Nuclear receptor coactivator 2 , NCoA-2 , Class E basic helix-loop-helix protein 75 , bHLHe75 , Transcriptional intermediary factor 2 , hTIF2
|Protein function|| |
Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues. Critical regulator of glucose metabolism regulation, acts as RORA coactivator to specifically modulate G6PC expression. Involved in the positive regulation of the transcriptional activity of the glucocorticoid receptor NR3C1 by sumoylation enhancer RWDD3. Positively regulates the circadian clock by acting as a transcriptional coactivator for the CLOCK-ARNTL/BMAL1 heterodimer (By similarity).
|Involvement in disease|| |
Note: Chromosomal aberrations involving NCOA2 may be a cause of acute myeloid leukemias. Inversion inv(8)(p11;q13) generates the KAT6A-NCOA2 oncogene, which consists of the N-terminal part of KAT6A and the C-terminal part of NCOA2/TIF2. KAT6A-NCOA2 binds to CREBBP and disrupts its function in transcription activation. .
|Protein sequence and domain|| |
Contains four Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs. The LXXLL motifs are essential for the association with nuclear receptors and are, at least in part, functionally redundant. / The LLXXLXXXL motif is involved in transcriptional coactivation and CREBBP/CBP binding. / Contains 2 C-terminal transcription activation domains (AD1 and AD2) that can function independently. / Belongs to the SRC/p160 nuclear receptor coactivator family. / Contains 1 bHLH (basic helix-loop-helix) domain. / Contains 1 PAS (PER-ARNT-SIM) domain.
|Protein cellular localization|| |
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St John’s Laboratory Ltd.
|Product type|| |
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