Rabbit Polyclonal Phospho-GRK 1 (S21) antibody (STJ90901)

$99.00$319.00

Reactivity: Human, Mouse, Rat, Monkey
Applications: WB, IHC, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Rabbit Polyclonal Phospho-GRK 1 (S21) antibody (STJ90901)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, IHC, ELISA

Recommended dilution: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:5000;

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for GRK 1 (phospho Ser21) Polyclonal Antibody.

Alternative names:

Check alternative names for the antibody

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GRK1 antibody, RHOK antibody,||
SCBT cat No: To be updated

 

Name

GRK 1 (phospho Ser21) Polyclonal Antibody

Catalogue No.

STJ90901

Reactivity

Human, Mouse, Rat, Monkey

Specificity

Phospho-GRK 1 (S21) Polyclonal Antibody detects endogenous levels of GRK 1 protein only when phosphorylated at S21.

Immunogen

Synthesized phospho-peptide derived from GRK 1 (phospho Ser21) at AA range 1-80

Host

Rabbit

Applications

WB, IHC, ELISA

Recommended dilution

WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:5000;

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

63 kDa

Formulation

GRK 1 (phospho Ser21) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

GRK 1 (phospho Ser21) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Rhodopsin kinase antibody, RK antibody, G protein-coupled receptor kinase 1 antibody

Database links

Human UniProt/Swiss-Prot:Q15835;Rat UniProt/Swiss-Port: Q63651;Human Entrez Gene: 6011;Mouse Entrez Gene: 24013;Rat Entrez Gene: Rn.10548

Protein names

Rhodopsin kinase , RK , G protein-coupled receptor kinase 1

Protein function

Retina-specific kinase involved in the signal turnoff via phosphorylation of rhodopsin (RHO), the G protein- coupled receptor that initiates the phototransduction cascade. This rapid desensitization is essential for scotopic vision and permits rapid adaptation to changes in illumination. / ATP + [rhodopsin] = ADP + [rhodopsin] phosphate. / Inhibited by phosphorylation of Ser-21. / 3.5 µM for rhodopsin / 10.6 µM for ATP / 1132 nmol/min/mg enzyme

Protein tissue specificity

Retinal-specific. Expressed in rods and cones cells.

Involvement in disease

Night blindness, congenital stationary, Oguchi type 2 (CSNBO2) [MIM:613411]: A non-progressive retinal disorder characterized by impaired night vision, often associated with nystagmus and myopia. Congenital stationary night blindness Oguchi type is associated with fundus discoloration and abnormally slow dark adaptation. . Note: The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. / Contains 1 AGC-kinase C-terminal domain. / Contains 1 protein kinase domain. / Contains 1 RGS domain.

Protein post-translational modifications

Autophosphorylated, Ser-21 is a minor site of autophosphorylation compared to Ser-491 and Thr-492 (By similarity). Phosphorylation at Ser-21 is regulated by light and activated by cAMP. / Farnesylation is required for full activity.

Protein cellular localization

Membrane / Lipid-anchor

Research area

All research areas>Kinases and Phosphatases>GRK
(View all antibody categories related to Kinases and Phosphatases)

Note

AntibodyPlus can customize GRK 1 (phospho Ser21) Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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