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Rabbit Polyclonal Phospho-GRK 1 (S21) antibody (STJ90901)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IHC, ELISA
Recommended dilution: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:5000;
Recommended protocols: check protocols
Click or hover above images to see image description for GRK 1 (phospho Ser21) Polyclonal Antibody.
Check alternative names for the antibodyExpand
GRK1 antibody, RHOK antibody,||
SCBT cat No: To be updated
GRK 1 (phospho Ser21) Polyclonal Antibody
|Catalogue No.|| |
Human, Mouse, Rat, Monkey
Phospho-GRK 1 (S21) Polyclonal Antibody detects endogenous levels of GRK 1 protein only when phosphorylated at S21.
Synthesized phospho-peptide derived from GRK 1 (phospho Ser21) at AA range 1-80
WB, IHC, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:5000;
|Molecular weight|| |
GRK 1 (phospho Ser21) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
GRK 1 (phospho Ser21) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Rhodopsin kinase antibody, RK antibody, G protein-coupled receptor kinase 1 antibody
|Protein names|| |
Rhodopsin kinase , RK , G protein-coupled receptor kinase 1
|Protein function|| |
Retina-specific kinase involved in the signal turnoff via phosphorylation of rhodopsin (RHO), the G protein- coupled receptor that initiates the phototransduction cascade. This rapid desensitization is essential for scotopic vision and permits rapid adaptation to changes in illumination. / ATP + [rhodopsin] = ADP + [rhodopsin] phosphate. / Inhibited by phosphorylation of Ser-21. / 3.5 µM for rhodopsin / 10.6 µM for ATP / 1132 nmol/min/mg enzyme
|Protein tissue specificity|| |
Retinal-specific. Expressed in rods and cones cells.
|Involvement in disease|| |
Night blindness, congenital stationary, Oguchi type 2 (CSNBO2) [MIM:613411]: A non-progressive retinal disorder characterized by impaired night vision, often associated with nystagmus and myopia. Congenital stationary night blindness Oguchi type is associated with fundus discoloration and abnormally slow dark adaptation. . Note: The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. / Contains 1 AGC-kinase C-terminal domain. / Contains 1 protein kinase domain. / Contains 1 RGS domain.
|Protein post-translational modifications|| |
Autophosphorylated, Ser-21 is a minor site of autophosphorylation compared to Ser-491 and Thr-492 (By similarity). Phosphorylation at Ser-21 is regulated by light and activated by cAMP. / Farnesylation is required for full activity.
|Protein cellular localization|| |
Membrane / Lipid-anchor
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St John’s Laboratory Ltd.
|Product type|| |
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