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Rabbit Polyclonal Phospho-GRK 2 (S685) antibody (STJ90616)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-1:2000; ELISA 1:5000;
Recommended protocols: check protocols
Click or hover above images to see image description for GRK 2 (phospho Ser685) Polyclonal Antibody.
Check alternative names for the antibodyExpand
ADRBK1 antibody, BARK antibody, BARK1 antibody, GRK2 antibody,|ADRBK1 antibody|Adrenergic beta receptor kinase 1 antibody|ARBK1_HUMAN antibody|BARK antibody|BARK1 antibody|Beta adrenergic receptor kinase 1 antibody|Beta ARK 1 antibody|Beta ARK1 antibody|Beta-adrenergic receptor kinase 1 antibody|Beta-ARK-1 antibody|FLJ16718 antibody|G protein coupled receptor kinase 2 antibody|G-protein coupled receptor kinase 2 antibody|GRK2 antibody|Anti-GRK2 antibody – C-terminal (ab137666)
SCBT cat No: sc-562|sc-18409|sc-13143|sc-166283|sc-166284|sc-271359|sc-8329|
GRK 2 (phospho Ser685) Polyclonal Antibody
|Catalogue No.|| |
Human, Mouse, Rat
Phospho-GRK 2 (S685) Polyclonal Antibody detects endogenous levels of GRK 2 protein only when phosphorylated at S685.
Synthesized phospho-peptide derived from GRK 2 (phospho Ser685) at AA range 620-700
|Recommended dilution|| |
WB 1:500-1:2000; ELISA 1:5000;
|Molecular weight|| |
GRK 2 (phospho Ser685) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
GRK 2 (phospho Ser685) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Beta-adrenergic receptor kinase 1 antibody, Beta-ARK-1 antibody, G-protein coupled receptor kinase 2 antibody
|Protein names|| |
Beta-adrenergic receptor kinase 1 , Beta-ARK-1 , G-protein coupled receptor kinase 2
|Protein function|| |
Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner. / ATP + [beta-adrenergic receptor] = ADP + [beta-adrenergic receptor] phosphate. / In contrast to other AGC family kinases, the catalytic activity is solely regulated by the binding of substrates and ligands, not by phosphorylation of the kinase domain.
|Protein tissue specificity|| |
Expressed in peripheral blood leukocytes.
|Protein sequence and domain|| |
The PH domain binds anionic phospholipids and helps recruiting ADRBK1 from the cytoplasm to plasma membrane close to activated receptors. It mediates binding to G protein beta and gamma subunits, competing with G-apha subunits and other G-betagamma effectors. / Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. / Contains 1 AGC-kinase C-terminal domain. / Contains 1 PH domain. / Contains 1 protein kinase domain. / Contains 1 RGS domain.
|Protein cellular localization|| |
Cytoplasm / Cell membrane
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St John’s Laboratory Ltd.
|Product type|| |
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