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Rabbit Polyclonal Phospho-GSK3A-S21 antibody (AP0120)
Supplier: ABclonal Inc.
Recommended applications: WB,IHC,IF
WB 1:500 – 1:2000
IHC 1:50 – 1:100
IF 1:100 – 1:200
Recommended protocols: check protocols
Click or hover above images to see image description for Rabbit Polyclonal Phospho-GSK3A-S21 antibody.
Check alternative names for the antibodyExpand
Factor A antibody|Glycogen synthase kinase 3 alpha antibody|Glycogen synthase kinase 3 beta antibody|GSK3 alpha antibody|GSK3 beta antibody|GSK3B antibody|Phospho anti-GSK3 (alpha + beta) (Y216 + Y279) antibody [EPR933Y] (ab68476)
SCBT cat No: sc-7291|sc-56913|sc-81462|sc-53931|sc-71186|sc-71188|sc-377213|sc-9166|sc-8257|sc-164567|sc-164569|sc-365863|sc-28966|sc-166882|sc-100546|sc-398714|
Rabbit Polyclonal Phospho-GSK3A-S21 antibody
|Catalogue No.|| |
Human, Mouse, Rat
A phospho specific peptide corresponding to residues surrounding S21 of human GSK3A
WB, IHC, IF
|Recommended dilution|| |
WB 1:500 – 1:2000<br/>IHC 1:50 – 1:100<br/>IF 1:100 – 1:200
|Molecular weight|| |
Phospho-GSK3A-S21 antibody was tube-contained.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Database links|| |
Human UniProt/Swiss-Prot:<a href="http://www.uniprot.org/uniprot/P49840">P49840</a>
|Protein function|| |
Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), CTNNB1/beta-catenin, APC and AXIN1. Requires primed phosphorylation of the majority of its substrates. Contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. Regulates glycogen metabolism in liver, but not in muscle. May also mediate the development of insulin resistance by regulating activation of transcription factors. In Wnt signaling, regulates the level and transcriptional activity of nuclear CTNNB1/beta-catenin. Facilitates amyloid precursor protein (APP) processing and the generation of APP-derived amyloid plaques found in Alzheimer disease. May be involved in the regulation of replication in pancreatic beta-cells. Is necessary for the establishment of neuronal polarity and axon outgrowth. Through phosphorylation of the anti-apoptotic protein MCL1, may control cell apoptosis in response to growth factors deprivation.
|Protein sequence and domain|| |
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.; Contains 1 protein kinase domain.
|Protein post-translational modifications|| |
Phosphorylated by AKT1 at Ser-21: upon insulin-mediated signaling, the activated PKB/AKT1 protein kinase phosphorylates and desactivates GSK3A, resulting in the dephosphorylation and activation of GYS1. Activated by phosphorylation at Tyr-279.
This gene encodes a multifunctional Ser/Thr protein kinase that is implicated in the control of several regulatory proteins including glycogen synthase, and transcription factors, such as JUN. It also plays a role in the WNT and PI3K signaling pathways, as well as regulates the production of beta-amyloid peptides associated with Alzheimer's disease.
|Research area|| |
<a href="http://antibodyplus.com/research-areas/">All research areas</a>><a href="http://antibodyplus.com/Kinases-and-Phosphatases/">Kinases and Phosphatases</a>><a href="http://antibodyplus.com/product-tag/GSK-3-alpha/">GSK-3 alpha</a><br><a href="http://antibodyplus.com/product-tag/Kinases-and-Phosphatases/"> (View all antibody categories related to Kinases and Phosphatases)</a>
AntibodyPlus can customize Phospho-GSK3A-S21 antibody according to your requirement, including bulk product size,etc. Please contact firstname.lastname@example.org. AntibodyPlus provides antibody trial sample for your own antibody validation.
|Product type|| |
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