Rabbit polyclonal Phospho-GSK3A-S21 antibody (AP0582)

$69.00$259.00

Reactivity: Human
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal Phospho-GSK3A-S21 antibody (AP0582)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

ChIP 1:20 – 1:100

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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Factor A antibody|Glycogen synthase kinase 3 alpha antibody|Glycogen synthase kinase 3 beta antibody|GSK3 alpha antibody|GSK3 beta antibody|GSK3B antibody|Phospho anti-GSK3 (alpha + beta) (Y216 + Y279) antibody [EPR933Y] (ab68476)

SCBT cat No: sc-7291|sc-56913|sc-81462|sc-53931|sc-71186|sc-71188|sc-377213|sc-9166|sc-8257|sc-164567|sc-164569|sc-365863|sc-28966|sc-166882|sc-100546|sc-398714|

Name

Rabbit polyclonal Phospho-GSK3A-S21 antibody

Catalogue No.

AP0582

Reactivity

Human

Immunogen

A phospho specific peptide corresponding to residues surrounding S21 of human GSK3A

Host

Rabbit

Applications

WB, IHC

Recommended dilution

ChIP 1:20 – 1:100

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 51kDa/Observed: Refer to figures

Formulation

Phospho-GSK3A-S21 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

Phospho-GSK3A-S21 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Database links

Human UniProt/Swiss-Prot:P49840

Protein function

Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), CTNNB1/beta-catenin, APC and AXIN1. Requires primed phosphorylation of the majority of its substrates. Contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. Regulates glycogen metabolism in liver, but not in muscle. May also mediate the development of insulin resistance by regulating activation of transcription factors. In Wnt signaling, regulates the level and transcriptional activity of nuclear CTNNB1/beta-catenin. Facilitates amyloid precursor protein (APP) processing and the generation of APP-derived amyloid plaques found in Alzheimer disease. May be involved in the regulation of replication in pancreatic beta-cells. Is necessary for the establishment of neuronal polarity and axon outgrowth. Through phosphorylation of the anti-apoptotic protein MCL1, may control cell apoptosis in response to growth factors deprivation.

Protein sequence and domain

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.; Contains 1 protein kinase domain.

Protein post-translational modifications

Phosphorylated by AKT1 at Ser-21: upon insulin-mediated signaling, the activated PKB/AKT1 protein kinase phosphorylates and desactivates GSK3A, resulting in the dephosphorylation and activation of GYS1. Activated by phosphorylation at Tyr-279.

Background

This gene encodes a multifunctional Ser/Thr protein kinase that is implicated in the control of several regulatory proteins including glycogen synthase, and transcription factors, such as JUN. It also plays a role in the WNT and PI3K signaling pathways, as well as regulates the production of beta-amyloid peptides associated with Alzheimer’s disease.

Research area

All research areas>Kinases and Phosphatases>GSK
(View all antibody categories related to Kinases and Phosphatases)

Note

AntibodyPlus can customize Phospho-GSK3A-S21 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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