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Rabbit Polyclonal Phospho-HDAC1 (S421) antibody (STJ90497)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IHC, ELISA
Recommended dilution: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:5000;
Recommended protocols: check protocols
Click or hover above images to see image description for HDAC1 (phospho Ser421) Polyclonal Antibody.
Check alternative names for the antibodyExpand
HDAC1 antibody, RPD3L1 antibody,|DKFZp686H12203 antibody|GON 10 antibody|HD1 antibody|HDAC 1 antibody|HDAC1 antibody|HDAC1_HUMAN antibody|Histone deacetylase 1 antibody|Reduced potassium dependency yeast homolog like 1 antibody|RPD3 antibody|RPD3L1 antibody|Anti-HDAC1 antibody – ChIP Grade
SCBT cat No: sc-81598|sc-6298|sc-8410|sc-7872|sc-6299|
HDAC1 (phospho Ser421) Polyclonal Antibody
|Catalogue No.|| |
Human, Mouse, Rat
Phospho-HDAC1 (S421) Polyclonal Antibody detects endogenous levels of HDAC1 protein only when phosphorylated at S421.
Synthesized phospho-peptide derived from HDAC1 (phospho Ser421) at AA range 360-440
WB, IHC, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:5000;
|Molecular weight|| |
HDAC1 (phospho Ser421) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
HDAC1 (phospho Ser421) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Histone deacetylase 1 antibody, HD1 antibody,
|Protein names|| |
Histone deacetylase 1 , HD1 ,
|Protein function|| |
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Deacetylates ‘Lys-310’ in RELA and thereby inhibits the transcriptional activity of NF-kappa-B. Deacetylates NR1D2 and abrogates the effect of KAT5-mediated relieving of NR1D2 transcription repression activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Involved in CIART-mediated transcriptional repression of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1 heterodimer. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex or CRY1 through histone deacetylation. / Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.
|Protein tissue specificity|| |
Ubiquitous, with higher levels in heart, pancreas and testis, and lower levels in kidney and brain.
|Protein sequence and domain|| |
Belongs to the histone deacetylase family. HD type 1 subfamily.
|Protein post-translational modifications|| |
Sumoylated on Lys-444 and Lys-476; which promotes enzymatic activity. Desumoylated by SENP1. / Phosphorylation on Ser-421 and Ser-423 promotes enzymatic activity and interactions with NuRD and SIN3 complexes. Phosphorylated by CDK5. / Ubiquitinated by CHFR, leading to its degradation by the proteasome. Ubiquitinated by KCTD11, leading to proteasomal degradation.
|Protein cellular localization|| |
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St John’s Laboratory Ltd.
|Product type|| |
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