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Rabbit Polyclonal Phospho-HDAC2-S394 antibody (AP0201)
Supplier: ABclonal Inc.
Recommended applications: WB,IHC,IF
WB 1:500 – 1:2000
IHC 1:50 – 1:100
IF 1:100 – 1:200
Recommended protocols: check protocols
Click or hover above images to see image description for Rabbit Polyclonal Phospho-HDAC2-S394 antibody.
Check alternative names for the antibodyExpand
HD2 antibody; RPD3 antibody; YAF1 antibody;
D10Wsu179e antibody|HD 2 antibody|HD2 antibody|HDAC 2 antibody|Hdac2 antibody|HDAC2_HUMAN antibody|Histone deacetylase 2 (HD2) antibody|Histone deacetylase 2 antibody|OTTHUMP00000017046 antibody|OTTHUMP00000227077 antibody|OTTHUMP00000227078 antibody|RPD3 antibody|transcriptional regulator homolog RPD3 antibody|YAF1 antibody|YY1 associated factor 1 antibody|YY1 transcription factor binding protein antibody|Yy1bp antibody|Anti-HDAC2 antibody [Y461] (ab32117)
SCBT cat No: sc-81599|sc-55541|sc-6296|sc-9959|sc-55542|sc-7899|sc-56685|sc-130319|
Rabbit Polyclonal Phospho-HDAC2-S394 antibody
|Catalogue No.|| |
Human, Mouse, Rat
A phospho specific peptide corresponding to residues surrounding S394 of human HDAC2
WB, IHC, IF
|Recommended dilution|| |
WB 1:500 – 1:2000<br/>IHC 1:50 – 1:100<br/>IF 1:100 – 1:200
|Molecular weight|| |
Phospho-HDAC2-S394 antibody was tube-contained.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Alternative antibody names|| |
HD2 antibody; RPD3 antibody; YAF1 antibody;
|Database links|| |
Human UniProt/Swiss-Prot:<a href="http://www.uniprot.org/uniprot/Q92769">Q92769</a>
|Protein names|| |
HD2; RPD3; YAF1;
|Protein function|| |
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor complex composed of DNMT1, DMAP1, PCNA, CAF1. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. May be involved in the transcriptional repression of circadian target genes, such as PER1, mediated by CRY1 through histone deacetylation. Involved in MTA1-mediated transcriptional corepression of TFF1 and CDKN1A.
|Protein tissue specificity|| |
Widely expressed; lower levels in brain and lung.
|Protein sequence and domain|| |
Belongs to the histone deacetylase family. HD type 1 subfamily.
|Protein post-translational modifications|| |
S-nitrosylated by GAPDH. In neurons, S-Nitrosylation at Cys-262 and Cys-274 does not affect the enzyme activity but abolishes chromatin-binding, leading to increases acetylation of histones and activate genes that are associated with neuronal development. In embryonic cortical neurons, S-Nitrosylation regulates dendritic growth and branching. S-Nitrosylation interferes with its interaction with MTA1 (By similarity).
|Protein cellular localization|| |
Nucleus . Cytoplasm .
This gene product belongs to the histone deacetylase family. Histone deacetylases act via the formation of large multiprotein complexes, and are responsible for the deacetylation of lysine residues at the N-terminal regions of core histones (H2A, H2B, H3 and H4). This protein forms transcriptional repressor complexes by associating with many different proteins, including YY1, a mammalian zinc-finger transcription factor. Thus, it plays an important role in transcriptional regulation, cell cycle progression and developmental events. Alternative splicing results in multiple transcript variants.
|Research area|| |
<a href="http://antibodyplus.com/research-areas/">All research areas</a>><a href="http://antibodyplus.com/Transcription-Regulators/">Transcription Regulators</a>><a href="http://antibodyplus.com/product-tag/HDAC/">HDAC</a><br><a href="http://antibodyplus.com/product-tag/Transcription-Regulators/"> (View all antibody categories related to Transcription Regulators)</a>
AntibodyPlus can customize Phospho-HDAC2-S394 antibody according to your requirement, including bulk product size,etc. Please contact email@example.com. AntibodyPlus provides antibody trial sample for your own antibody validation.
|Product type|| |
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